Swiss-Prot entry
ID KCNN4_RAT STANDARD; PRT; 425 AA.
AC Q9QYW1; Q9R198; Q9WVA5;
DT 28-FEB-2003 (Rel. 41, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Intermediate conductance calcium-activated potassium channel protein 4
DE (SK4) (KCa4) (IK1).
GN Name=Kcnn4; Synonyms=Ik1, Sk4, Smik;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar Kyoto; TISSUE=Aortic smooth muscle;
RX MEDLINE=20004720; PubMed=10532960 [NCBI, ExPASy, EBI, Israel, Japan];
RA Neylon C., Lang R.J., Fu Y., Bobik A., Reinhart P.H.;
RT "Molecular cloning and characterization of the intermediate-
RT conductance Ca(2+)-activated K(+) channel in vascular smooth muscle:
RT relationship between K(Ca) channel diversity and smooth muscle cell
RT function.";
RL Circ. Res. 85:E33-E43(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar; TISSUE=Colon;
RX MEDLINE=99448580; PubMed=10519135 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1007/s004240051059;
RA Warth R., Hamm K., Bleich M., Kunzelmann K., von Hahn T.,
RA Schreiber R., Ullrich E., Mengel M., Trautmann N., Kindle P.,
RA Schwab A., Greger R.;
RT "Molecular and functional characterization of the small Ca2+-regulated
RT K+ channel (rSK4) of colonic crypts.";
RL Pflugers Arch. 438:437-444(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley;
RA Fujiwara Y., Saito T., Sasamura R., Miura M.;
RT "Rat intermediate conductance calcium-activated potassium channel.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley;
RA Rajendran V.M., Sangan P., Joiner W.J., Binder H.J.;
RT "cDNA cloning of an intermediate conductance Ca2+-activated K+ channel
RT (rIK1) and its regulation by dietary K-depletion in rat distal
RT colon.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms a voltage-independent potassium channel that is
CC activated by intracellular calcium. Activation is followed by
CC membrane hyperpolarization which promotes calcium influx. The
CC channel is blocked by clotrimazole and charybdotoxin but is
CC insensitive to apamin (By similarity).
CC -!- SUBUNIT: Heterotetramer of potassium channel proteins (Probable).
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- SIMILARITY: Belongs to the potassium channel KCNN family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AF190458; AAF05602.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF149250; AAD38032.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ133438; CAB40141.2; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF156554; AAD38205.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P70604; 1KKD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IDA.
DR GO; GO:0006811; P:ion transport; TAS.
DR InterPro; IPR004178; CaM_bd.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; IPR003091; K_channel.
DR InterPro; IPR011996; SK.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF03530; SK_channel; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00169; KCHANNEL.
DR CMR; Q9QYW1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q9QYW1.
DR ProtoNet; Q9QYW1.
DR ProtoMap; Q9QYW1.
DR PRESAGE; Q9QYW1.
DR DIP; Q9QYW1.
DR ModBase; Q9QYW1.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Calmodulin-binding; Ion transport; Ionic channel; Transmembrane;
KW Transport.
FT TRANSMEM 30 50 Segment S1 (Potential).
FT TRANSMEM 59 79 Segment S2 (Potential).
FT TRANSMEM 105 121 Segment S3 (Potential).
FT TRANSMEM 141 161 Segment S4 (Potential).
FT TRANSMEM 205 225 Segment S5 (Potential).
FT TRANSMEM 239 259 Segment H5 (pore-forming) (Potential).
FT TRANSMEM 263 283 Segment S6 (Potential).
FT REGION 284 345 Calmodulin-binding (By similarity).
FT COMPBIAS 413 416 Poly-Gln.
FT CONFLICT 213 213 L -> F (in Ref. 2).
FT CONFLICT 280 280 V -> L (in Ref. 4).
FT CONFLICT 395 395 D -> H (in Ref. 4).
FT CONFLICT 399 399 G -> R (in Ref. 4).
FT CONFLICT 410 410 T -> S (in Ref. 4).
FT CONFLICT 416 416 Missing (in Ref. 4).
SQ SEQUENCE 425 AA; 47767 MW; E861DB088D20D8FC CRC64;
MGGELVTGLG ALRRRKRLLE QEKRVAGWAL VLAGTGIGLM VLHAEMLWFL GCKWVLYLLL
VKCLITLSTA FLLCLIVVFH AKEVQLFMTD NGLRDWRVAL TRRQVAQILL ELLVCGVHPV
PLRSPHCTLA GEATDSQAWP GFLGEGEALL SLAMLLRLYL VPRAVLLRSG VLLNASYRSI
GALNQVRFRH WFVAKLYMNT HPGRLLLGLT LGLWLTTAWV LSVAERQAVN ATGHLTDTLW
LIPITFLTIG YGDVVPGTLW GKIVCLCTGV MGVCCTALLV AVVARKLEFN KAEKHVHNFM
MDIHYAKEMK ESAARLLQEA WMYYKHTRRK DSRAARRHQR KMLAAIHTFR QVRLKHRKLR
EQVNSMVDIS KMHMILCDLQ LGLSASHLAL EKRIDGLAGK LDALTELLST ALQQQQPPEP
IQEAT
//