Swiss-Prot entry

ID   KCNN3_MOUSE    STANDARD;      PRT;   731 AA.
AC   P58391;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Small conductance calcium-activated potassium channel protein 3 (SK3).
GN   Name=Kcnn3; Synonyms=Sk3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c; TISSUE=Colon;
RX   MEDLINE=21440983; PubMed=11557517 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Ro S., Hatton W.J., Koh S.D., Horowitz B.;
RT   "Molecular properties of small-conductance Ca2+-activated K+ channels
RT   expressed in murine colonic smooth muscle.";
RL   Am. J. Physiol. 281:G964-G973(2001).
CC   -!- FUNCTION: Forms a voltage-independent potassium channel activated
CC       by intracellular calcium. Activation is followed by membrane
CC       hyperpolarization. Thought to regulate neuronal excitabilty by
CC       contributing to the slow component of synaptic
CC       afterhyperpolarization. The channel is blocked by apamin (By
CC       similarity).
CC   -!- SUBUNIT: Hetero-oligomer. The complex is composed of 4 channel
CC       subunits each of which binds to a calmodulin subunit which
CC       regulates the channel activity through calcium-binding (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNN family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF357241; AAK48902.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P70604; 1KKD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P58391; 544-635.
DR   Ensembl; ENSMUSG00000000794; Mus_musculus
DR   MGI; MGI:2153183; Kcnn3.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   InterPro; IPR004178; CaM_bd.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR011996; SK.
DR   InterPro; IPR003931; SK_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF03530; SK_channel; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01451; SKCHANNEL.
DR   CMR; P58391.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P58391.
DR   ProtoNet; P58391.
DR   ProtoMap; P58391.
DR   PRESAGE; P58391.
DR   DIP; P58391.
DR   ModBase; P58391.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Calmodulin-binding; Ion transport; Ionic channel; Transmembrane;
KW   Transport.
FT   TRANSMEM    288    308       Segment S1 (Potential).
FT   TRANSMEM    315    335       Segment S2 (Potential).
FT   TRANSMEM    366    386       Segment S3 (Potential).
FT   TRANSMEM    405    425       Segment S4 (Potential).
FT   TRANSMEM    454    474       Segment S5 (Potential).
FT   TRANSMEM    494    514       Segment H5 (pore-forming) (Potential).
FT   TRANSMEM    523    543       Segment S6 (Potential).
FT   REGION      561    637       Calmodulin-binding (By similarity).
FT   COMPBIAS     30     35       Poly-Gln.
FT   COMPBIAS     36     43       Poly-Pro.
FT   COMPBIAS     60     79       Poly-Gln.
FT   COMPBIAS    683    687       Poly-Gln.
FT   COMPBIAS    727    730       Poly-Ser.
SQ   SEQUENCE   731 AA;  81255 MW;  E509C97E975C1A42 CRC64;
     MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQPPPPP APPAVPQQPP GPLLQPQPPQ
     PQQQQSQQQQ QQQSQQQQQA PLHPLPQLAQ LQSQLVHPGL LHSSPTAFRA PTSANSTAIL
     HPSSRQGSQL NLNDHLLGHS PSSTATSGPG GGSRHRQASP LVHRRDSNPF TEIAMSSCKY
     SGGVMKPLSR LSASRRNLIE AEPEGQPLQL FSPSNPPEII ISSREDNHAH QTLLHHPNAT
     HNHQHAGTTA GSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI
     ETELSWGLYS KDSMFSLALK CLISLSTVIL LGLIIAYHTR EVQLFVIDNG ADDWRIAMTY
     ERIFYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE ADVDIILSIP MFLRLYLIAR
     VMLLHSKLFT DASSRSIGAL NKINFNTRFV MKTLMTICPG TVLLVFSISL WIIAAWTVRV
     CERYHDQQDV TSNFLGAMWL ISITFLSIGY GDMVPHTYCG KGVCLLTGIM GAGCTALVVA
     VVARKLELTK AEKHVHNFMM DTQLTKRIKN AATNVLRETW LVYKHTKLLK KIDHAKVRKH
     QRKFLQAIHQ LRGVKMEQRK LSDQANTLVD LSKMQNVMYD LITELNDRSE DLEKQIGSLE
     SKLEHLTASF NSLPLLIADT LRQQQQQLLT AFVEARGISV AVGTSHAPPS DSPIGISSTS
     FPTPYTSSSS C
//