Swiss-Prot entry

ID   KCNN2_MOUSE    STANDARD;      PRT;   574 AA.
AC   P58390;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Small conductance calcium-activated potassium channel protein 2 (SK2).
GN   Name=Kcnn2; Synonyms=Sk2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c; TISSUE=Colon;
RX   MEDLINE=21440983; PubMed=11557517 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Ro S., Hatton W.J., Koh S.D., Horowitz B.;
RT   "Molecular properties of small-conductance Ca2+-activated K+ channels
RT   expressed in murine colonic smooth muscle.";
RL   Am. J. Physiol. 281:G964-G973(2001).
CC   -!- FUNCTION: Forms a voltage-independent potassium channel activated
CC       by intracellular calcium. Activation is followed by membrane
CC       hyperpolarization. Thought to regulate neuronal excitabilty by
CC       contributing to the slow component of synaptic
CC       afterhyperpolarization. The channel is blocked by apamin (By
CC       similarity).
CC   -!- SUBUNIT: Hetero-oligomer. The complex is composed of 4 channel
CC       subunits each of which binds to a calmodulin subunit which
CC       regulates the channel activity through calcium-binding (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNN family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF357240; AAK48901.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P70604; 1KKD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P58390; 390-481.
DR   Ensembl; ENSMUSG00000054477; Mus_musculus
DR   MGI; MGI:2153182; Kcnn2.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   InterPro; IPR004178; CaM_bd.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR011996; SK.
DR   InterPro; IPR003931; SK_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF03530; SK_channel; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01451; SKCHANNEL.
DR   CMR; P58390.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P58390.
DR   ProtoNet; P58390.
DR   ProtoMap; P58390.
DR   PRESAGE; P58390.
DR   DIP; P58390.
DR   ModBase; P58390.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Calmodulin-binding; Ion transport; Ionic channel; Transmembrane;
KW   Transport.
FT   TRANSMEM    133    153       Segment S1 (Potential).
FT   TRANSMEM    163    183       Segment S2 (Potential).
FT   TRANSMEM    209    229       Segment S3 (Potential).
FT   TRANSMEM    251    271       Segment S4 (Potential).
FT   TRANSMEM    300    320       Segment S5 (Potential).
FT   TRANSMEM    340    360       Segment H5 (pore-forming) (Potential).
FT   TRANSMEM    369    389       Segment S6 (Potential).
FT   REGION      407    483       Calmodulin-binding (By similarity).
FT   COMPBIAS     42     46       Poly-Gly.
FT   COMPBIAS     52     56       Poly-Ala.
FT   COMPBIAS     80     85       Poly-Gly.
FT   COMPBIAS     88     97       Poly-Gly.
FT   COMPBIAS    558    561       Poly-Arg.
SQ   SEQUENCE   574 AA;  63482 MW;  259CB8CDE4D1CDE6 CRC64;
     MSSCRYNGGV MRPLSNLSSS RRNLQEMDSE AQPLQPPASV VGGGGGASSP SAAAAASSSA
     PEIVVSKPEH NNSNNLALYG TGGGGSTGGG GGGSGHGSSS GTKSSKKKNQ NIGYKLGHRR
     ALFEKRKRLS DYALIFGMFG IVVMVIETEL SWGAYDKASL YSLALKCLIS LSTIILLGLI
     IVYHAREIQL FMVDNGADDW RIAMTYERIF FICLEILVCA IHPIPGNYTF TWTARLAFSY
     APSTTTADVD IILSIPMFLR LYLIARVMLL HSKLFTDASS RSIGALNKIN FNTRFVMKTL
     MTICPGTVLL VFSISLWIIA AWTVRACERY HDQQDVTSNF LGAMWLISIT FLSIGYGDMV
     PNTYCGKGVC LLTGIMGAGC TALVVAVVAR KLELTKAEKH VHNFMMDTQL TKRVKNAAAN
     VLRETWLIYK NTKLVKKIDH AKVRKHQRKF LQAIHQLRSV KMEQRKLNDQ ANTLVDLAKT
     QNIMYDMISD LNERSEDFEK RIVTLETKLE TLIGSIHALP GLISQTIRQQ QRDFIETQME
     NYDKHVSYNA ERSRSSSRRR RSSSTAPPTS SESS
//