Swiss-Prot entry
ID KCNN1_MOUSE STANDARD; PRT; 580 AA.
AC Q9EQR3; Q99JA9;
DT 28-FEB-2003 (Rel. 41, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Small conductance calcium-activated potassium channel protein 1 (SK1).
GN Name=Kcnn1; Synonyms=Sk1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE, ALTERNATIVE SPLICING, AND POLYMORPHISM OF
RP POLY-GLU REGION.
RC STRAIN=CD-1;
RX MEDLINE=21167369; PubMed=11267657 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0167-4781(01)00166-X;
RA Shmukler B.E., Bond C.T., Wilhelm S., Bruening-Wright A., Maylie J.,
RA Adelman J.P., Alper S.L.;
RT "Structure and complex transcription pattern of the mouse SK1 KCa
RT channel gene, KCNN1.";
RL Biochim. Biophys. Acta 1518:36-46(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/c; TISSUE=Colon;
RX MEDLINE=21440983; PubMed=11557517 [NCBI, ExPASy, EBI, Israel, Japan];
RA Ro S., Hatton W.J., Koh S.D., Horowitz B.;
RT "Molecular properties of small-conductance Ca2+-activated K+ channels
RT expressed in murine colonic smooth muscle.";
RL Am. J. Physiol. 281:G964-G973(2001).
CC -!- FUNCTION: Forms a voltage-independent potassium channel activated
CC by intracellular calcium. Activation is followed by membrane
CC hyperpolarization. Thought to regulate neuronal excitabilty by
CC contributing to the slow component of synaptic
CC afterhyperpolarization. The channel is blocked by apamin (By
CC similarity).
CC -!- SUBUNIT: Hetero-oligomer. The complex is composed of 4 channel
CC subunits each of which binds to a calmodulin subunit which
CC regulates the channel activity through calcium-binding (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=At least 16 isoforms are produced. The gene is composed
CC of at least 12 exons. Exons A, 3.2 or C, B, 3.2, 6, 8, 8, 10, 8,
CC 10, 8A and 10 are alternatively spliced;
CC Name=1;
CC IsoId=Q9EQR3-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Widely expressed including brain.
CC -!- POLYMORPHISM: The poly-Glu region of KCNN1 is polymorphic and the
CC number of Glu varies between strains (from 10 to 12). The repeat
CC with 10 Glu residues (shown here) is found in BALB/c, DBA/2J,
CC 129/SvJ, A/J, C3H/HeJ, BALB/cJ, BXD-31, SM/J, ST/BJ, FVB/NJ,
CC NZB/B1NJ, CBA/J and CAST/Ei.
CC -!- SIMILARITY: Belongs to the potassium channel KCNN family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AF116525; AAG43216.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF297870; AAK30363.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF297869; AAK30363.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF303461; AAK29550.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF303462; AAK29551.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF303463; AAK29552.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF357239; AAK48900.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P70604; 1KKD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; Q9EQR3; 407-501.
DR Ensembl; ENSMUSG00000002908; Mus_musculus
DR MGI; MGI:1933993; Kcnn1.
DR GO; GO:0016021; C:integral to membrane; TAS.
DR GO; GO:0005516; F:calmodulin binding; IDA.
DR InterPro; IPR004178; CaM_bd.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; IPR011996; SK.
DR InterPro; IPR003931; SK_channel.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF03530; SK_channel; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01451; SKCHANNEL.
DR CMR; Q9EQR3.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q9EQR3.
DR ProtoNet; Q9EQR3.
DR ProtoMap; Q9EQR3.
DR PRESAGE; Q9EQR3.
DR DIP; Q9EQR3.
DR ModBase; Q9EQR3.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Alternative splicing; Calmodulin-binding; Ion transport;
KW Ionic channel; Polymorphism; Transmembrane; Transport.
FT TRANSMEM 151 171 Segment S1 (Potential).
FT TRANSMEM 180 200 Segment S2 (Potential).
FT TRANSMEM 219 239 Segment S3 (Potential).
FT TRANSMEM 268 288 Segment S4 (Potential).
FT TRANSMEM 317 337 Segment S5 (Potential).
FT REGION 357 377 Segment H5 (pore-forming) (Potential).
FT REGION 386 406 Segment S6 (Potential).
FT REGION 424 503 Calmodulin-binding (By similarity).
FT COMPBIAS 107 118 Poly-Glu.
FT VARSPLIC 1 43 Missing (in isoforms without exon A/3.2
FT OR C/B/3.2).
FT /FTId=VSP_002809.
FT VARSPLIC 394 430 Missing (in isoforms without exon 6/8).
FT /FTId=VSP_002810.
FT VARSPLIC 466 580 KFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYE
FT VVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAI
FT CPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG -> LRSS
FT EV (in isoforms with exon 8/10).
FT /FTId=VSP_002811.
FT VARSPLIC 466 580 KFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYE
FT VVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAI
FT CPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG -> SEV
FT (in isoforms with exon 8/10).
FT /FTId=VSP_002812.
FT VARSPLIC 474 476 Missing (in isoforms without exon 8A/10).
FT /FTId=VSP_002813.
FT VARIANT 109 109 E -> EE (in strain C57BL/6J, strain A/HeJ
FT and strain SPRET/Ei).
FT VARIANT 109 109 E -> EEE (in strain SWR/J, strain AKR/J,
FT strain RBF/DNJ and strain P/J).
FT VARIANT 565 565 H -> Q (in strain C57BL/6J).
SQ SEQUENCE 580 AA; 64066 MW; 7B30C8A28B349C80 CRC64;
MFWNGQGDVQ PLLSPQVHSE ALLRNHAGPQ RACCTPSPRR QVAMSSHSHN GSVGQPLGSG
PGFLGWEPVD PEAGRPLQPT QGPGLQMVAK GQPVRLSPGG SRGHPQEQEE EEEEEEEEDK
TGSGKPPTVS HRLGHRRALF EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLCSF
ALKCLISLST VILLGLVILY HAREIQLFLV DNGADDWRIA MTWERVSLIS LELVVCAIHP
VPGHYRFTWT ARLAFSLVPS AAEADLDVLL SIPMFLRLYL LARVMLLHSR IFTDASSRSI
GALNRVTFNT RFVTKTLMTI CPGTVLLVFS VSSWIVAAWT VRVCERYHDK QEVTSNFLGA
MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL VVAVVARKLE LTKAEKHVHN
FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQGRV RKHQRKFLQA IHQAQKLRSV
KIEQGKVNDQ ANTLAELAKA QSIAYEVVSE LQAQQEELEA RLAALESRLD VLGASLQALP
GLIAQAICPL PPPWPGPGHL ATATHSPQSH WLPTMGSDCG
//