Swiss-Prot entry
ID KCNE4_HUMAN STANDARD; PRT; 170 AA.
AC Q8WWG9; Q96CC4;
DT 28-FEB-2003 (Rel. 41, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Potassium voltage-gated channel subfamily E member 4 (Minimum
DE potassium ion channel-related peptide 3) (Potassium channel beta
DE subunit MiRP3) (MinK-related peptide 3).
GN Name=KCNE4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Heart, and Kidney;
RA Hui R., Teng S., Lin C., Ma L., Zhen Y.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [3]
RP ASSOCIATION WITH KCNQ1, AND TISSUE SPECIFICITY.
RX MEDLINE=22090825; PubMed=12096056 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1113/jphysiol.2002.017301;
RA Grunnet M., Jespersen T., Rasmussen H.B., Ljungstroem T.,
RA Jorgensen N.K., Olesen S.-P., Klaerke D.A.;
RT "KCNE4 is an inhibitory subunit to the KCNQ1 channel.";
RL J. Physiol. (Lond.) 542:119-130(2002).
CC -!- FUNCTION: Ancillary protein that assembles as a beta subunit with
CC a voltage-gated potassium channel complex of pore-forming alpha
CC subunits. Modulates the gating kinetics and enhances stability of
CC the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit
CC potassium current.
CC -!- SUBUNIT: Associates with KCNQ1/KVLQT1 (Probable).
CC -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in embryo and adult
CC uterus. Low expression found in kidney, small intestine, lung and
CC heart.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AY065987; AAL49979.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC014429; AAH14429.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR Ensembl; ENSG00000152049; Homo_sapiens
DR HGNC; HGNC:6244; KCNE4.
DR CleanEx; HGNC:6244; KCNE4.
DR MIM; 607775; -. [NCBI / EBI]
DR GeneCards; KCNE4.
DR GeneLynx; KCNE4.
DR GenAtlas; KCNE4.
DR SOURCE; KCNE4.
DR InterPro; IPR000369; ISK_Channel.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF02060; ISK_Channel; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00168; KCNECHANNEL.
DR CMR; Q8WWG9.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q8WWG9.
DR ProtoNet; Q8WWG9.
DR ProtoMap; Q8WWG9.
DR PRESAGE; Q8WWG9.
DR DIP; Q8WWG9.
DR ModBase; Q8WWG9.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Glycoprotein; Ion transport; Ionic channel; Potassium;
KW Potassium channel; Potassium transport; Transmembrane; Transport;
KW Voltage-gated channel.
FT TRANSMEM 36 56 Potential.
FT TOPO_DOM 57 170 Cytoplasmic (Potential).
FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).
FT CONFLICT 54 54 M -> V (in Ref. 1).
FT CONFLICT 86 86 P -> S (in Ref. 1).
SQ SEQUENCE 170 AA; 18439 MW; 4F6C94F87BF71B52 CRC64;
MLKMEPLNST HPGTAASSSP LESRAAGGGS GNGNEYFYIL VVMSFYGIFL IGIMLGYMKS
KRREKKSSLL LLYKDEERLW GEAMKPLPVV SGLRSVQVPL MLNMLQESVA PALSCTLCSM
EGDSVSSESS SPDVHLTIQE EGADEELEET SETPLNESSE GSSENIHQNS
//