Swiss-Prot entry

ID   KCNE3_MOUSE    STANDARD;      PRT;   103 AA.
AC   Q9WTW2;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Potassium voltage-gated channel subfamily E member 3 (Minimum
DE   potassium ion channel-related peptide 2) (Potassium channel beta
DE   subunit MiRP2) (MinK-related peptide 2).
GN   Name=Kcne3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Mus. 
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.;
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with
CC       a voltage-gated potassium channel complex of pore-forming alpha
CC       subunits. Modulates the gating kinetics and enhances stability of
CC       the channel complex. Associated with KCNC4/Kv3.4 is proposed to
CC       form the subthreshold voltage-gated potassium channel in skeletal
CC       muscle and to establish the resting membrane potential (RMP) in
CC       muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal
CC       cAMP-stimulated potassium channel involved in chloride secretion
CC       (By similarity).
CC   -!- SUBUNIT: Associates with KCNC4/Kv3.4. May associate with
CC       KCNQ1/KCLQT1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF076532; AAD28090.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   EMBL; BC004629; AAH04629.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   Ensembl; ENSMUSG00000035165; Mus_musculus
DR   MGI; MGI:1891124; Kcne3.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   InterPro; IPR000369; ISK_Channel.
DR   InterPro; IPR005426; KCNE_beta3.
DR   InterPro; Graphical view of domain structure.
DR   PRINTS; PR01606; KCNE3CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
DR   CMR; Q9WTW2.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q9WTW2.
DR   ProtoNet; Q9WTW2.
DR   ProtoMap; Q9WTW2.
DR   PRESAGE; Q9WTW2.
DR   DIP; Q9WTW2.
DR   ModBase; Q9WTW2.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; Ion transport; Ionic channel; Potassium;
KW   Potassium channel; Potassium transport; Transmembrane; Transport;
KW   Voltage-gated channel.
FT   TRANSMEM     58     78       Potential.
FT   TOPO_DOM     79    103       Cytoplasmic (Potential).
FT   CARBOHYD      5      5       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     22     22       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     41     41       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   103 AA;  11720 MW;  92E7C8C2284A8804 CRC64;
     METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL PGRNDNSYMY
     ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMI
//