Swiss-Prot entry

ID   KCNE2_RABIT    STANDARD;      PRT;    71 AA.
AC   Q9BDR0;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Potassium voltage-gated channel subfamily E member 2 (Minimum
DE   potassium ion channel-related peptide 1) (Potassium channel beta
DE   subunit MiRP1) (MinK-related peptide 1) (Fragment).
GN   Name=KCNE2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; 
OC   Oryctolagus. 
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21313430; PubMed=11420311 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Yu H., Wu J., Potapova I., Wymore R.T., Holmes B., Zuckerman J.,
RA   Pan Z., Wang H., Shi W., Robinson R.B., El-Maghrabi M.R., Benjamin W.,
RA   Dixon J.E., McKinnon D., Cohen I.S., Wymore R.;
RT   "MinK-related peptide 1: a beta subunit for the HCN ion channel
RT   subunit family enhances expression and speeds activation.";
RL   Circ. Res. 88:E84-E87(2001).
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with
CC       a voltage-gated potassium channel complex of pore-forming alpha
CC       subunits. Modulates the gating kinetics and enhances stability of
CC       the channel complex. Associated with KCNH2/HERG is proposed to
CC       form the rapidly activating component of the delayed rectifying
CC       potassium current in heart (IKr). May associate with KCNQ2 and/or
CC       KCNQ3 and modulate the native M-type current. May associate with
CC       KCNQ1/KCLQT1 and elicit a voltage-independent current (By
CC       similarity).
CC   -!- SUBUNIT: Associates with KCNH2/ERG1 (By similarity). May associate
CC       with KCNQ1/KVLQT1, KCNQ2 and KCNQ3. Associates with HCN1 and
CC       probably HCN2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC   -!- TISSUE SPECIFICITY: Detected in heart; expression is highest in
CC       the SA node and the right atrium, and barely detectable in the
CC       ventricle.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
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DR   EMBL; AF329636; AAK15527.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   InterPro; IPR000369; ISK_Channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00168; KCNECHANNEL.
DR   BLOCKS; Q9BDR0.
DR   ProtoNet; Q9BDR0.
DR   ProtoMap; Q9BDR0.
DR   PRESAGE; Q9BDR0.
DR   DIP; Q9BDR0.
DR   ModBase; Q9BDR0.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Ion transport; Ionic channel; Potassium; Potassium channel;
KW   Potassium transport; Transmembrane; Transport; Voltage-gated channel.
FT   TRANSMEM      7     27       Potential.
FT   TOPO_DOM     28    >71       Cytoplasmic (Potential).
FT   NON_TER       1      1
FT   NON_TER      71     71
SQ   SEQUENCE   71 AA;  8557 MW;  4A667539D4032CEA CRC64;
     AENFYYVILY LMVMIGMFSF IIVAILVSTV KSKRREHSND PYHQYIVEDW QEKYKSQILH
     FEEAKATIHE N
//