Swiss-Prot entry
ID KCNE1_MOUSE STANDARD; PRT; 129 AA.
AC P23299;
DT 01-NOV-1991 (Rel. 20, Created)
DT 01-NOV-1991 (Rel. 20, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Potassium voltage-gated channel subfamily E member 1 (IKs producing
DE slow voltage-gated potassium channel beta subunit Mink) (Minimal
DE potassium channel) (Delayed rectifier potassium channel subunit IsK)
DE (mISK).
GN Name=Kcne1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Heart;
RX MEDLINE=92007723; PubMed=1655403 [NCBI, ExPASy, EBI, Israel, Japan];
RA Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F.,
RA Lazdunski M., Barhanin J.;
RT "Cloning, expression, pharmacology and regulation of a delayed
RT rectifier K+ channel in mouse heart.";
RL EMBO J. 10:2805-2811(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92233938; PubMed=1568475 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0014-5793(92)81240-M;
RA Lesage F., Attali B., Lazdunski M., Barhanin J.;
RT "ISK, a slowly activating voltage-sensitive K+ channel.
RT Characterization of multiple cDNAs and gene organization in the
RT mouse.";
RL FEBS Lett. 301:168-172(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX MEDLINE=22354683; PubMed=12466851 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/nature01266;
RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S.,
RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H.,
RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.,
RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J.,
RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W.,
RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S.,
RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S.,
RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J.,
RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D.,
RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L.,
RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A.,
RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H.,
RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G.,
RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S.,
RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M.,
RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K.,
RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M.,
RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C.,
RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L.,
RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N.,
RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K.,
RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S.,
RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I.,
RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A.,
RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J.,
RA Birney E., Hayashizaki Y.;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
CC -!- FUNCTION: Ancillary protein that assembles as a beta subunit with
CC a voltage-gated potassium channel complex of pore-forming alpha
CC subunits. Modulates the gating kinetics and enhances stability of
CC the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to
CC form the slowly activating delayed rectifier cardiac potassium
CC (IKs) channel. The outward current reaches its steady state only
CC after 50 seconds. Assembled with KCNH2/HERG may modulate the
CC rapidly activating component of the delayed rectifying potassium
CC current in heart (IKr) (By similarity).
CC -!- SUBUNIT: Associates with KCNQ1/KVLQT1 and KCNH2/HERG (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC -!- TISSUE SPECIFICITY: Restrictively localized in the apical membrane
CC portion of epithelial cells.
CC -!- PTM: Phosphorylation inhibits the potassium current (By
CC similarity).
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; X60457; CAA42990.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AK028907; BAC26189.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S17307; S17307.
DR Ensembl; ENSMUSG00000039639; Mus_musculus
DR MGI; MGI:96673; Kcne1.
DR GO; GO:0016021; C:integral to membrane; TAS.
DR InterPro; IPR000369; ISK_Channel.
DR InterPro; IPR005424; KCNE_beta1.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF02060; ISK_Channel; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01604; KCNE1CHANNEL.
DR PRINTS; PR00168; KCNECHANNEL.
DR CMR; P23299.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P23299.
DR ProtoNet; P23299.
DR ProtoMap; P23299.
DR PRESAGE; P23299.
DR DIP; P23299.
DR ModBase; P23299.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Direct protein sequencing; Glycoprotein; Ion transport; Ionic channel;
KW Phosphorylation; Potassium; Potassium channel; Potassium transport;
KW Transmembrane; Transport; Voltage-gated channel.
FT TRANSMEM 44 66 Potential.
FT TOPO_DOM 67 129 Cytoplasmic (Potential).
FT MOD_RES 102 102 Phosphoserine (by PKC) (By similarity).
FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 26 26 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 129 AA; 14578 MW; E66DF4742300E839 CRC64;
MSLPNSTTVL PFLARLWQET AEQGGNVSGL ARKSQLRDDS KLEALYILMV LGFFGFFTLG
IMLSYIRSKK LEHSHDPFNV YIESDAWQEK GKAVFQARVL ESFRACYVIE NQAAVEQPAT
HLPELKPLS
//