Swiss-Prot entry

ID   KCNE1_CAVPO    STANDARD;      PRT;   125 AA.
AC   Q60409; Q9QVZ5;
DT   30-MAY-2000 (Rel. 39, Created)
DT   30-MAY-2000 (Rel. 39, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Potassium voltage-gated channel subfamily E member 1 (IKs producing
DE   slow voltage-gated potassium channel beta subunit Mink) (Minimal
DE   potassium channel) (Delayed rectifier potassium channel subunit IsK).
GN   Name=KCNE1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; 
OC   Hystricognathi; Caviidae; Cavia. 
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Heart;
RX   MEDLINE=94089666; PubMed=8265583 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Varnum M.D., Busch A.E., Bond C.T., Maylie J., Adelman J.P.;
RT   "The min K channel underlies the cardiac potassium current IKs and
RT   mediates species-specific responses to protein kinase C.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:11528-11532(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Heart muscle;
RX   MEDLINE=94173910; PubMed=7510407 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Zhang J., Jurkiewicz N.K., Folander K., Lazarides E., Salata J.J.,
RA   Swanson R.;
RT   "K+ currents expressed from the guinea pig cardiac IsK protein are
RT   enhanced by activators of protein kinase C.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:1766-1770(1994).
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with
CC       a voltage-gated potassium channel complex of pore-forming alpha
CC       subunits. Modulates the gating kinetics and enhances stability of
CC       the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to
CC       form the slowly activating delayed rectifier cardiac potassium
CC       (IKs) channel. The outward current reaches its steady state only
CC       after 50 seconds. Assembled with KCNH2/HERG may modulate the
CC       rapidly activating component of the delayed rectifying potassium
CC       current in heart (IKr) (By similarity).
CC   -!- SUBUNIT: Associates with KCNQ1/KVLQT1 and KCNH2/HERG (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC   -!- PTM: Phosphorylation inhibits the potassium current (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; L20462; AAA72394.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; A49392; A49392.
DR   PIR; I48146; I48146.
DR   InterPro; IPR000369; ISK_Channel.
DR   InterPro; IPR005424; KCNE_beta1.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01604; KCNE1CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q60409.
DR   ProtoNet; Q60409.
DR   ProtoMap; Q60409.
DR   PRESAGE; Q60409.
DR   DIP; Q60409.
DR   ModBase; Q60409.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; Ion transport; Ionic channel; Phosphorylation;
KW   Potassium; Potassium channel; Potassium transport; Transmembrane;
KW   Transport; Voltage-gated channel.
FT   TRANSMEM     44     66       Potential.
FT   TOPO_DOM     67    125       Cytoplasmic (Potential).
FT   CARBOHYD      5      5       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     26     26       N-linked (GlcNAc...) (Potential).
FT   CONFLICT     15     17       TVW -> SVM (in Ref. 1).
SQ   SEQUENCE   125 AA;  14266 MW;  E5CB6843D9AB5E76 CRC64;
     MILPNSTAVM PFLTTVWQGT VQPSSNASGL ARRSPLRDDG KLEALYILMV LGFFGFFTLG
     IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAFFQARVL ENCRSCCVIE NQLTVEQPNT
     YLPEL
//