Swiss-Prot entry

ID   KCNB2_RAT      STANDARD;      PRT;   907 AA.
AC   Q63099;
DT   15-JUL-1998 (Rel. 36, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Potassium voltage-gated channel subfamily B member 2 (Voltage-gated
DE   potassium channel subunit Kv2.2) (CDRK).
GN   Name=Kcnb2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; 
OC   Muridae; Murinae; Rattus. 
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   MEDLINE=92198655; PubMed=1550672 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Hwang P.M., Glatt C.E., Bredt D.S., Yellen G., Snyder S.H.;
RT   "A novel K+ channel with unique localizations in mammalian brain:
RT   molecular cloning and characterization.";
RL   Neuron 8:473-481(1992).
CC   -!- FUNCTION: Mediates the voltage-dependent potassium ion
CC       permeability of excitable membranes. Channels open or close in
CC       response to the voltage difference across the membrane, letting
CC       potassium ions pass in accordance with their electrochemical
CC       gradient.
CC   -!- SUBUNIT: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- TISSUE SPECIFICITY: In the brain, the greatest density occurs in
CC       the olfactory bulb, followed by the cerebral cortex, hippocampus,
CC       and cerebellum. In peripheral tissues it is most prominent in
CC       whole tongue epithelium and circumvallate papillae.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at
CC       every third position.
CC   -!- DOMAIN: The tail may be important in modulation of channel
CC       activity and/or targeting of the channel to specific subcellular
CC       compartments.
CC   -!- PTM: Phosphorylated (Potential).
CC   -!- SIMILARITY: Belongs to the potassium channel family. B (Shab)
CC       subfamily.
CC   -!- CAUTION: Ref.1 sequence differs from that shown due to a
CC       frameshift in position 755.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; M77482; AAA40905.1; ALT_FRAME; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; Q16968; 1A68. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   Ensembl; ENSRNOG00000028991; Rattus_norvegicus
DR   RGD; 621349; Kcnb2.
DR   InterPro; IPR000210; BTB_POZ.
DR   InterPro; IPR005821; Ion_trans.
DR   InterPro; IPR001622; K+channel_pore.
DR   InterPro; IPR003091; K_channel.
DR   InterPro; IPR003131; K_tetra.
DR   InterPro; IPR005826; Kv22channel.
DR   InterPro; IPR003968; Kv_channel.
DR   InterPro; IPR005820; M+channel_nlg.
DR   InterPro; IPR003973; Shab_channel.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02214; K_tetra; 1.
DR   Pfam; PF03521; Kv2channel; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01515; KV22CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01495; SHABCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   CMR; Q63099.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q63099.
DR   ProtoNet; Q63099.
DR   ProtoMap; Q63099.
DR   PRESAGE; Q63099.
DR   DIP; Q63099.
DR   ModBase; Q63099.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; Ion transport; Ionic channel; Multigene family;
KW   Phosphorylation; Potassium; Potassium channel; Potassium transport;
KW   Transmembrane; Transport; Voltage-gated channel.
FT   TOPO_DOM      1    190       Cytoplasmic (Potential).
FT   TRANSMEM    191    212       Segment S1 (Potential).
FT   TRANSMEM    233    254       Segment S2 (Potential).
FT   TOPO_DOM    255    264       Cytoplasmic (Potential).
FT   TRANSMEM    265    286       Segment S3 (Potential).
FT   TRANSMEM    299    320       Segment S4 (Potential).
FT   TOPO_DOM    321    334       Cytoplasmic (Potential).
FT   TRANSMEM    335    356       Segment S5 (Potential).
FT   TRANSMEM    397    418       Segment S6 (Potential).
FT   TOPO_DOM    419    907       Cytoplasmic (Potential).
FT   REGION      369    389       Segment H5 (pore-forming) (Potential).
FT   MOTIF       381    386       Selectivity filter (By similarity).
FT   CARBOHYD    287    287       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   907 AA;  102096 MW;  B242D9A6753A1295 CRC64;
     MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR
     LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG
     QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR DGEGEEFDNT CCPEKRKKLW
     DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE NDEFGQPSDN RKLAHVEAVC
     IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV
     QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE
     DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF
     SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KAGESANIKD
     SVDDNHLSPS RWKWARKALS ETSSNKSYEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL
     EMLYNEITKT QTHSHPNPDC QEQPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST
     SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGM DEHQRVRAPP FLTLSRDKGP
     AAREAALDYA PIDITVNLDA GASHGPLQPD SASDSPKSSL KGSNPLKSRS LKVNFQENRG
     SAPQTPPSTA RPLPVTTADF PLTTPQHMST ILLEESPPPG TETLPGADVS AHCQGPSKGL
     SPRVPKQKLF PFSSRERRSF TEIDTGEDED FLDLQRPRPD KQADPSPNCL ADKPGEARDP
     LREEGCVGSS SPQNTDHNCR QDIYQAVGEV KKDSSQEGYK MENHLFAPEI HSNPGDTGYC
     PTRETSM
//