Swiss-Prot entry

ID   KCMB1_CANFA    STANDARD;      PRT;   190 AA.
AC   Q28266;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Calcium-activated potassium channel beta subunit 1 (Calcium-activated
DE   potassium channel, subfamily M, beta subunit 1) (Maxi K channel beta
DE   subunit 1) (BK channel beta subunit 1) (Slo-beta 1) (K(VCA)beta 1)
DE   (Charybdotoxin receptor beta subunit 1) (BKbeta1) (Calcium-activated
DE   potassium channel beta-subunit) (BKbeta) (Slo-beta).
GN   Name=KCNMB1;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Fissipedia; Canidae; 
OC   Canis. 
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97053370; PubMed=8897882 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Vogalis F., Vincent T., Qureshi I., Schmalz F.M., Ward M.W.,
RA   Sanders K.M., Horowitz B.;
RT   "Cloning and expression of the large-conductance Ca(2+)-activated K+
RT   channel from colonic smooth muscle.";
RL   Am. J. Physiol. 271:G629-G639(1996).
CC   -!- FUNCTION: Regulatory subunit of the calcium activated potassium
CC       KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and
CC       gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel
CC       diversity. Increases the apparent Ca(2+)/voltage sensitivity of
CC       the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and
CC       alters its pharmacological properties. It slows down the
CC       activation and the deactivation kinetics of the channel. Acts as a
CC       negative regulator of smooth muscle contraction by enhancing the
CC       calcium sensitivity to KCNMA1. Its presence is also a requirement
CC       for internal binding of the KCNMA1 channel opener
CC       dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external
CC       binding of the agonist hormone 17-beta-estradiol (E2). Increases
CC       the binding activity of charybdotoxin (CTX) toxin to KCNMA1
CC       peptide blocker by increasing the CTX association rate and
CC       decreasing the dissociation rate (By similarity).
CC   -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4
CC       molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- PTM: N-glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the KCNMB family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; U41002; AAA84001.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   Ensembl; ENSCAFG00000016956; Canis_familiaris
DR   InterPro; IPR003930; BK_channel_beta.
DR   InterPro; Graphical view of domain structure.
DR   PANTHER; PTHR10258; BK_channel_beta; 1.
DR   Pfam; PF03185; CaKB; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR01450; BKCHANNELB.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; Q28266.
DR   ProtoNet; Q28266.
DR   ProtoMap; Q28266.
DR   PRESAGE; Q28266.
DR   DIP; Q28266.
DR   ModBase; Q28266.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   Glycoprotein; Ion transport; Ionic channel; Transmembrane; Transport.
FT   INIT_MET      0      0       By similarity.
FT   TOPO_DOM      1     14       Cytoplasmic (Potential).
FT   TRANSMEM     15     35       1 (Potential).
FT   TOPO_DOM     36    156       Extracellular (Potential).
FT   TRANSMEM    157    177       2 (Potential).
FT   TOPO_DOM    178    190       Cytoplasmic (Potential).
FT   CARBOHYD     79     79       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    141    141       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   190 AA;  21803 MW;  087715070A35D3C8 CRC64;
     GKKLVMAQKR GETRALCLGV AMVMCAVIAY YILGTTMLPL YQKSVWTQKS TCHLIETNIR
     EQEELEGKKV PQYPCLWVNV SAVGRWAVLY HTEDTRDQNH QCSYIPGSLE NYQVARADVE
     KVKAKFHEQQ IFYCFSTTRE NETTVLYRRL YGPQTLLFSL FWPTFLLTGG LLIIAMVKIN
     QSLSILAAQR
//