Swiss-Prot entry
ID KCAB2_RAT STANDARD; PRT; 367 AA.
AC P62483; P97381; Q60942; Q64284;
DT 16-OCT-2001 (Rel. 40, Created)
DT 16-OCT-2001 (Rel. 40, Last sequence update)
DT 13-SEP-2005 (Rel. 48, Last annotation update)
DE Voltage-gated potassium channel beta-2 subunit (K(+) channel beta-2
DE subunit) (Kv-beta-2).
GN Name=Kcnab2; Synonyms=Ckbeta2, Kcnb3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain cortex;
RX MEDLINE=94239521; PubMed=8183366 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/369289a0;
RA Rettig J., Heinemann S.H., Wunder F., Lorra C., Parcej D.N.,
RA Dolly J.O., Pongs O.;
RT "Inactivation properties of voltage-gated K+ channels altered by
RT presence of beta-subunit.";
RL Nature 369:289-294(1994).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 36-367, INTERACTION WITH
RP KCNA1, AND TETRAMERIZATION.
RX PubMed=10884227 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1126/science.289.5476.123;
RA Gulbis J.M., Zhou M., Mann S., MacKinnon R.;
RT "Structure of the cytoplasmic beta subunit-T1 assembly of voltage-
RT dependent K+ channels.";
RL Science 289:123-127(2000).
CC -!- FUNCTION: Accessory potassium channel protein which modulates the
CC activity of the pore-forming alpha subunit.
CC -!- SUBUNIT: Forms heteromultimeric complex with alpha subunits.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic (Potential).
CC -!- DOMAIN: Alteration of functional properties of alpha subunit is
CC mediated through N-terminal domain of beta subunit (Probable).
CC -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC family.
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DR EMBL; X76724; CAA54142.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S45312; S45312.
DR PDB; 1EXB; X-ray; A=36-367. [ExPASy / RCSB]
DR PDB; 1QRQ; X-ray; A/B/C/D=36-360. [ExPASy / RCSB]
DR SMR; P62483; 36-361.
DR Ensembl; ENSRNOG00000011550; Rattus_norvegicus
DR RGD; 61828; Kcnab2.
DR InterPro; IPR001395; Aldo/ket_red.
DR InterPro; IPR005401; KCNAB2_channel.
DR InterPro; IPR005402; KCNAB3_channel.
DR InterPro; IPR005399; KCNAB_channel.
DR InterPro; IPR005983; KCNAB_euk.
DR InterPro; Graphical view of domain structure.
DR PANTHER; PTHR11732:SF69; KCNAB_channel; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00069; ALDKETRDTASE.
DR PRINTS; PR01579; KCNAB2CHANEL.
DR PRINTS; PR01580; KCNAB3CHANEL.
DR PRINTS; PR01577; KCNABCHANNEL.
DR ProDom; PD000288; Aldo/ket_red; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR TIGRFAMs; TIGR01293; Kv_beta; 1.
DR CMR; P62483.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P62483.
DR ProtoNet; P62483.
DR ProtoMap; P62483.
DR PRESAGE; P62483.
DR DIP; P62483.
DR ModBase; P62483.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW 3D-structure; Ion transport; Ionic channel; Phosphorylation;
KW Potassium; Potassium transport; Transport; Voltage-gated channel.
FT MOD_RES 20 20 Phosphoserine (By similarity).
FT STRAND 39 41
FT TURN 43 44
FT STRAND 48 50
FT STRAND 52 55
FT HELIX 59 63
FT HELIX 66 78
FT TURN 79 80
FT STRAND 83 87
FT TURN 88 89
FT HELIX 90 93
FT HELIX 94 106
FT TURN 107 107
FT HELIX 110 112
FT STRAND 114 119
FT STRAND 121 121
FT HELIX 126 128
FT STRAND 129 129
FT HELIX 133 147
FT TURN 148 148
FT STRAND 152 157
FT TURN 162 163
FT HELIX 166 178
FT TURN 179 180
FT STRAND 182 188
FT HELIX 192 205
FT TURN 206 206
FT STRAND 212 216
FT STRAND 218 218
FT TURN 219 220
FT STRAND 221 221
FT HELIX 223 227
FT TURN 228 228
FT HELIX 229 236
FT STRAND 239 243
FT TURN 245 246
FT HELIX 247 252
FT TURN 253 255
FT TURN 261 262
FT HELIX 264 266
FT TURN 268 269
FT HELIX 271 278
FT HELIX 280 299
FT TURN 300 300
FT HELIX 303 312
FT TURN 315 316
FT STRAND 317 322
FT HELIX 327 334
FT TURN 335 335
FT HELIX 336 339
FT HELIX 340 342
FT HELIX 345 355
SQ SEQUENCE 367 AA; 41021 MW; 5303FD1411B324FC CRC64;
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF
GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF
WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG
MAMYWGTSRW SSMEIMEAYS VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA
MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG
CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE IDSILGNKPY
SKKDYRS
//