Swiss-Prot entry
ID IRK13_HUMAN STANDARD; PRT; 360 AA.
AC O60928; O76023; Q8N3Y4;
DT 16-OCT-2001 (Rel. 40, Created)
DT 16-OCT-2001 (Rel. 40, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Inward rectifier potassium channel 13 (Potassium channel, inwardly
DE rectifying, subfamily J, member 13) (Inward rectifier K(+) channel
DE Kir7.1).
GN Name=KCNJ13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND VARIANT ILE-175.
RC TISSUE=Brain;
RX MEDLINE=98408852; PubMed=9738472 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0014-5793(98)00972-7;
RA Partiseti M., Collura V., Agnel M., Culouscou J.-M., Graham D.;
RT "Cloning and characterization of a novel human inwardly rectifying
RT potassium channel predominantly expressed in small intestine.";
RL FEBS Lett. 434:171-176(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain;
RX MEDLINE=98282025; PubMed=9620703 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0896-6273(00)80480-8;
RA Krapivinsky G., Medina I., Eng L., Krapivinsky L., Yang Y.,
RA Clapham D.E.;
RT "A novel inward rectifier K+ channel with unique pore properties.";
RL Neuron 20:995-1005(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Small intestine;
RA Hirose S., Suzuki Y., Nakamura N.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE.
RA Nakamura N., Matsuki T., Suzuki Y., Sakuta H., Ito T., Hirose S.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis;
RA Doering F., Derst C., Wischmeyer E., Karschin C., Daut J.,
RA Karschin A.;
RT "Unique epithelial Kir7.1 subunit defines a new subfamily of inwardly
RT rectifying potassium channels.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-175.
RC TISSUE=Brain;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE OF 147-175.
RX MEDLINE=99097357; PubMed=9878260 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1006/geno.1998.5598;
RA Derst C., Doring F., Preisig-M ueller R., Daut J., Karschin A.,
RA Jeck N., Weber S., Engel H., Grzeschik K.-H.;
RT "Partial gene structure and assignment to chromosome 2q37 of the human
RT inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13).";
RL Genomics 54:560-563(1998).
CC -!- FUNCTION: Inward rectifier potassium channels are characterized by
CC a greater tendancy to allow potassium to flow into the cell rather
CC than out of it. Their voltage dependence is regulated by the
CC concentration of extracellular potassium; as external potassium is
CC raised, the voltage range of the channel opening shifts to more
CC positive voltages. The inward rectification is mainly due to the
CC blockage of outward current by internal magnesium. KCNJ13 has a
CC very low single channel conductance, low sensitivity to block by
CC external barium and cesium, and no dependence of its inward
CC rectification properties on the internal blocking particle
CC magnesium.
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- TISSUE SPECIFICITY: Predominantly expresssed in small intestine.
CC Expression is also detected in stomach, kidney, and all central
CC nervous system regions tested with the exception of spinal cord.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AJ007557; CAA07552.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF061118; AAC15769.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AB013889; BAA28271.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AB013891; BAA28273.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AJ006128; CAA06878.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC037290; AAH37290.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF082182; AAD08673.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR HSSP; P35562; 1N9P. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR Ensembl; ENSG00000115474; Homo_sapiens
DR HGNC; HGNC:6259; KCNJ13.
DR CleanEx; HGNC:6259; KCNJ13.
DR MIM; 603208; -. [NCBI / EBI]
DR GeneCards; KCNJ13.
DR GeneLynx; KCNJ13.
DR GenAtlas; KCNJ13.
DR SOURCE; KCNJ13.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; NAS.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; NAS.
DR GO; GO:0006813; P:potassium ion transport; NAS.
DR InterPro; IPR001838; K+channel_IR.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; IPR008062; KIR7_channel.
DR InterPro; Graphical view of domain structure.
DR PANTHER; PTHR11767; K+channel_IR; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01679; KIR7CHANNEL.
DR PRINTS; PR01320; KIRCHANNEL.
DR ProDom; PD001103; K+channel_IR; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR CMR; O60928.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; O60928.
DR ProtoNet; O60928.
DR ProtoMap; O60928.
DR PRESAGE; O60928.
DR DIP; O60928.
DR ModBase; O60928.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW Ion transport; Ionic channel; Polymorphism; Potassium;
KW Potassium transport; Transmembrane; Transport; Voltage-gated channel.
FT TOPO_DOM 1 53 Cytoplasmic (By similarity).
FT TRANSMEM 54 78 M1 (By similarity).
FT TOPO_DOM 79 105 Extracellular (By similarity).
FT TOPO_DOM 125 133 Extracellular (By similarity).
FT TRANSMEM 134 155 M2 (By similarity).
FT TOPO_DOM 156 360 Cytoplasmic (By similarity).
FT REGION 106 117 H5 (pore-forming helix) (By similarity).
FT MOTIF 119 124 Selectivity filter (By similarity).
FT SITE 149 149 Role in the control of polyamine-mediated
FT channel gating and in the blocking by
FT intracellular magnesium (By similarity).
FT VARIANT 175 175 T -> I (in dbSNP:1801251).
FT /FTId=VAR_016193.
FT CONFLICT 290 290 P -> Q (in Ref. 6).
FT CONFLICT 309 309 G -> C (in Ref. 6).
SQ SEQUENCE 360 AA; 40530 MW; 0C49D0DBC619BC50 CRC64;
MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD MRWRWMMLVF
SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV KYITSFTAAF SFSLETQLTI
GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDTAVVAH
MDGKPNLIFQ VANTRPSPLT SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP
LTYYHSITPS SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA
SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN FQISETGLTE
//