Swiss-Prot entry
ID HCN1_RAT STANDARD; PRT; 910 AA.
AC Q9JKB0;
DT 28-FEB-2003 (Rel. 41, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated
DE channel 1.
GN Name=Hcn1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX MEDLINE=20457301; PubMed=11000485 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0169-328X(00)00155-8;
RA Monteggia L.M., Eisch A.J., Tang M.D., Kaczmarek L.K., Nestler E.J.;
RT "Cloning and localization of the hyperpolarization-activated cyclic
RT nucleotide-gated channel family in rat brain.";
RL Brain Res. Mol. Brain Res. 81:129-139(2000).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX MEDLINE=21530492; PubMed=11675786 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/35098087;
RA Stevens D.R., Seifert R., Bufe B., Mueller F., Kremmer E., Gauss R.,
RA Meyerhof W., Kaupp U.B., Lindemann B.;
RT "Hyperpolarization-activated channels HCN1 and HCN4 mediate responses
RT to sour stimuli.";
RL Nature 413:631-635(2001).
CC -!- FUNCTION: Hyperpolarization-activated ion channel exhibiting weak
CC selectivity for potassium over sodium ions. Contributes to the
CC native pacemaker currents in heart (If) and in neurons (Ih).
CC Activated by cAMP, and at 10-100 times higher concentrations, also
CC by cGMP (By similarity). May mediate responses to sour stimuli.
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming subunits. Heteromultimer
CC with HCN2 (By similarity). Interacts with KCNE2 (By similarity).
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in cerebral cortex,
CC cerebellum, throughout the hippocampus, in medial habenula,
CC anterior dorsal nucleus in the thalamus, tenia tecta, several
CC nuclei of the general motor system and in optic nerve layer.
CC Detected in a subset of elongated cells in taste buds.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at
CC every third position.
CC -!- SIMILARITY: Belongs to the potassium channel family. HCN
CC subfamily.
CC -!- SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AF247450; AAF62173.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR SMR; Q9JKB0; 390-590.
DR Ensembl; ENSRNOG00000011522; Rattus_norvegicus
DR InterPro; IPR000595; cNMP_binding.
DR InterPro; IPR003938; EAG_ELK_ERG.
DR InterPro; IPR005821; Ion_trans.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; IPR005820; M+channel_nlg.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; FALSE_NEG.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR CMR; Q9JKB0.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; Q9JKB0.
DR ProtoNet; Q9JKB0.
DR ProtoMap; Q9JKB0.
DR PRESAGE; Q9JKB0.
DR DIP; Q9JKB0.
DR ModBase; Q9JKB0.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW cAMP; cAMP-binding; Glycoprotein; Ion transport; Ionic channel;
KW Nucleotide-binding; Potassium; Potassium channel; Potassium transport;
KW Sodium; Sodium channel; Sodium transport; Transmembrane; Transport;
KW Voltage-gated channel.
FT TOPO_DOM 1 135 Cytoplasmic (Potential).
FT TRANSMEM 136 156 Segment S1 (Potential).
FT TRANSMEM 163 183 Segment S2 (Potential).
FT TOPO_DOM 184 208 Cytoplasmic (Potential).
FT TRANSMEM 209 229 Segment S3 (Potential).
FT TRANSMEM 238 258 Segment S4 (Potential).
FT TOPO_DOM 259 289 Cytoplasmic (Potential).
FT TRANSMEM 290 310 Segment S5 (Potential).
FT TRANSMEM 334 355 Segment H5 (pore-forming) (Potential).
FT TRANSMEM 361 381 Segment S6 (Potential).
FT TOPO_DOM 382 910 Cytoplasmic (Potential).
FT NP_BIND 464 581 cAMP.
FT REGION 78 129 Involved in subunit assembly (By
FT similarity).
FT COMPBIAS 715 777 Gln-rich.
FT COMPBIAS 878 884 Poly-Pro.
FT CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 910 AA; 102422 MW; 11E32D2BE73F4528 CRC64;
MEGGGKPNSA SNSRDDGNSV YPSKAPATGP AAADKRLGTP PGGGAAGKEH GNSVCFKVDG
GGGEEPAGSF EDAEGPRRQY GFMQRQFTSM LQPGVNKFSL RMFGSQKAVE KEQERVKTAG
FWIIHPYSDF RFYWDLIMLI MMVGNLVIIP VGITFFTEQT TTPWIIFNVA SDTVFLLDLI
MNFRTGTVNE DSSEIILDPK VIKMNYLKSW FVVDFISSIP VDYIFLIVEK GMDSEVYKTA
RALRIVRFTK ILSLLRLLRL SRLIRYIHQW EEIFHMTYDL ASAVVRIFNL IGMMLLLCHW
DGCLQFLVPL LQDFPPDCWV SLNEMVNDSW GKQYSYALFK AMSHMLCIGY GAQAPVSMSD
LWITMLSMIV GATCYAMFVG HATALIQSLD SSRRQYQEKY KQVEQYMSFH KLPADMRQKI
HDYYEHRYQG KIFDEENILS ELNDPLREEI VNFNCRKLVA TMPLFANADP NFVTAMLSKL
RFEVFQPGDY IIREGAVGKK MYFIQHGVAG VITKSSKEMK LTDGSYFGEI CLLTKGRRTA
SVRADTYCRL YSLSVDNFNE VLEEYPMMRR AFETVAIDRL DRIGKKNSIL LQKFQKDLNT
GVFNNQENEI LKQIVKHDRE MVQAIPPINY PQMTALNCTS STTTPTSRMR TQSPPVYTAT
SLSHSNLHSP SPSTQTPQPS AILSPCSYTT AVCSPPIQSP LATRTFHYAS PTASQLSLMQ
QPQPQLQQSQ VQQTQTQTQQ QQQQQQPQPQ PQQPQQQQQQ QQQQQQQQQQ QQQQQPQTPG
SSTPKNEVHK STQALHNTHL TREVRPLSAS QPSLPHEVST MISRPHPTVG ESLASIPQPV
ATVHSTGLQA GSRSTVPQRV TLFRQMSSGA IPPNRGVPPA PPPPAAVQRE SPSVLNKDPD
AEKPRFASNL
//