KChannelDB HCN (BCNG,HAC)
2005, KChannelDB.
CONSENSUS MEGGGKPNSGSNSRDEGRSVFPLAAPATGPGPAAAPARLGPPPGRGAAGASEEGPSVCFKVDGAAAGAASGGGAAEPAGG
HCN1_HUMAN MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGG
Q86WJ6_HUMAN MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGG
HCN1_RAT MEGGGKPNSASNSRDDGNSVYPSKAPAT..GPAAADKRLGTPPGGGAAG.KEHGNSVCFKVD........GGGGEEPAGS
HCN1_MOUSE MEGGGKPNSASNSRDDGNSVFPSKAPAT..GPVAADKRLGTPPGGGAAG.KEHGNSVCFKVD........GGGGEEPAGS
HCN4_RAT EERRLIAAEGDASPGEDRTPPGLATEPERPGAAAQPAASPPPQQPppASASCEQPSADTAIKV.......EGGAAASDQI
HCN4_HUMAN AEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQppASASCEQPSVDTAIKV.......EGGAAAGDQI
HCN4_MOUSE EERRLIAAEGDASPGEDRTPPGLATEPERPATAAQPAASPPPQQPppASASCEQPSADTAIKV.......EGGAAAIDHI
HCN1_RABIT ................................................................MATASSPPRRPRRARG
HCN4_RABIT STGGGSHGHLHDSAEERRLIAEGDASptPPGLAAEPERPGAPA..PPAASPPQVPSSCGEQRPADAAVKVEGGAAAGDQI
HCN2_MOUSE PPPNPTTPSHPESADEPGPRARLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGS
Q6BCT5_RAT PPPNPTTPSHPESADEPGPRSRLCSRDSSCTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPAAAEEAGS
Q71N53_ONCMY ....................MEDKSNSFSSNKEGEKADGNNVFQRQDSIQKNNMGSQNMKGGDHGNSVGFKGDREEALVG
HCN2_HUMAN DEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEAGS
HCN3_MOUSE ...................MEEEARPAAGAGEAATPARETPP....AAPAQARAAS...............GGVPESA..
HCN3_RAT ...................MEEEARPAVGDGEAATPARETPP....AAPAQARAAS...............GGVPESA..
HCN3_HUMAN .......................................MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSG
Q86WJ5_HUMAN .......................................MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSG
140
==|=======
CONSENSUS FEDAEGPRRQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLIMLLLMVGNLIII
HCN1_HUMAN FEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVII
Q86WJ6_HUMAN FEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVII
HCN1_RAT FEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVII
HCN1_MOUSE FEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVII
HCN4_RAT LPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII
HCN4_HUMAN LPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII
HCN4_MOUSE LPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII
HCN1_RABIT LEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVII
HCN4_RABIT LPEAEARLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIII
HCN2_MOUSE EepAGEPRgqASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIII
Q6BCT5_RAT EepAGEPRgqASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIII
Q71N53_ONCMY FDDIDGSGNRHGFMQRQFGAMMQPGVNKFSLRMFGSQKAVEKEQERVQTAGYWIIHPYSDFRFYWDLVMLVMMMGNLIII
HCN2_HUMAN EepAGEPRgqASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIII
HCN3_MOUSE ...PEPKRRQLGT.......LLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVL
HCN3_RAT ...PEPKRRQLGT.......LLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVL
HCN3_HUMAN ...PEPKRRHLGT.......LLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVL
Q86WJ5_HUMAN ...PEPKRRHLGT.......LLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVL
150 250 340 350
==|====== =========|======== ==|=========|=====
CONSENSUS PVGITFFKEETTTPWIVFNVVSDTFFLLDLVLNFRTGIVVEDNTEIILDPKVIKMKYLKSWFVVDFISSIPVDYIFLIVE
HCN1_HUMAN PVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
Q86WJ6_HUMAN PVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWSVVDFISSIPVDYIFLIVE
HCN1_RAT PVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
HCN1_MOUSE PVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
HCN4_RAT PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVE
HCN4_HUMAN PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE
HCN4_MOUSE PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVEYIFLIVE
HCN1_RABIT PVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
HCN4_RABIT PVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVE
HCN2_MOUSE PVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWF