2005, KChannelDB.
CONSENSUS MAGLSSPPMAQKSRNGGGVYPGAGSGEKKLAVGFVGLDPGAEDSTGDGALLAEQVTLALGGGGIAGSEAPKRGSGASEGG
Q5VYU3_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ2_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
Q5VYU5_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
Q5VYU4_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ2_MOUSE ........MVQKSRNG.GVYPG.TSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSVLS..K
KCNQ2_RAT ........MVQKSRNG.GVYPG.TSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSVLS..K
KCNQ3_MOUSE .MGLKARTAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGREEGQ
KCNQ3_RAT .MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGTGADKDGTLLLEGGGREEGQ
KCNQ3_HUMAN ..MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQ
KCNQ3_BOVIN ..MGLKARRPAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQ
Q5VVP3_HUMAN AAGLWVKSGAAAAAAGGGRL...GSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
KCNQ1_HUMAN MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLG
Q5UAX1_COLLI ..............MGLKARRGAAGGSA...AGGAAAAAAGRRGTASGVGDPEQGSLALGTGADRDGTLLLEGGGKEEGG
Q5BN39_COLLI ......MGDAMPRNHGGGEEGGSAGLWMKSGATAGMKDVESGRGRALASGSARGDGLLLLGTGGAAAPAGLREGRRGKHG
KCNQ1_RAT MDTASSPPNAERKRAGWGRLLGARRGSAGLAKKCPFSLELAEGGPTGGTVYAPIatGAPGLAPPMSPPVSPVPAPAD.LG
KCNQ5_HUMAN ..........................MKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
KCNQ1_MOUSE MDTASSPPSAERKRAGWSRLLGARRGSAVVK.KCPFSLELAEGGPEGSTVYAPIatGAPGLAPPMSTPVSPAPAPAD.LG
Q5VYU2_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ4_HUMAN ......MAEAPPRRLGLGPPPGDAPRAELVALTAVQ....SEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG
KCNQ1_SQUAC ...........MSSEVKSRWSGSGSQKSGTARKPTMlaENAASRHYEPVPLPLQRSNSPDSSTDKNPESRAADSRAeiNP
Q967F8_CAEEL ....................MDEESGSSTDQAAPSDEQQEAGSSSAIGQESRKTVVFQEPDIGFPSEHDQLTTLHDSEEG
Q60SW1_CAEBR .....................................................MLTTTGYPNGSSLVDDSPQDQDESEHF
Q86W40_HUMAN AAGLWVKSGAAAAAAGGGRL...GSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
140 150
==|=========|====== ===
CONSENSUS PRTPLSAGGAGSGKPPRRNAFYRRRLQNFLYNVLERPRGWKAFIYHAYVFLLVFGCLILSVFSTIKEYEKLSEGALLILE
Q5VYU3_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
Q5VYU5_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
Q5VYU4_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_MOUSE PRT....GGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_RAT PRT....GGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ3_MOUSE RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
KCNQ3_RAT RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
KCNQ3_HUMAN RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
KCNQ3_BOVIN RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFREYETVSGDWLLLLE
Q5VVP3_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
KCNQ1_HUMAN PRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
Q5UAX1_COLLI KRSPPGLGLLAKTPLSrrNHAKYRRIQTLIYDALERPRGW.ALLYHAFVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
Q5BN39_COLLI ARMSLLGKPLSygPSCRRNAKYR.RLQNYLYNVLERPRGW.AFVYHAFVFLLVFGCLILSVFSTIPEHTKLASGCLFILE
KCNQ1_RAT PRPRVSLDPRVSIYSTRRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
KCNQ5_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
KCNQ1_MOUSE PRPRVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
Q5VYU2_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ4_HUMAN QR.........SSAAHKR....YRRLQNWVYNVLERPRGW.AFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILE
KCNQ1_SQUAC DIPPKAIALPLSRYRGRNPFFSKVNIQGRTYNFLERPTGWKCFIYHFTVFLIVLVCLIFSVMSTIEQYHYFANRALVWME
Q967F8_CAEEL NRKM.SLVGKPLTYKNYRTDQRFRRMQNKMHNFLERPRGWKAATYHLAVLFMVLMCLALSVFSTMPDFEVNATIVLYYLE
Q60SW1_CAEBR LLGMVTGDGLGKMFNArrNiaAKMTYRALIYNCLERPTGWKCFLYHFSVFLVVLICLILSVLSTVEEHSHFAAELLYILE
Q86W40_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
250 340 350 450
======|======== ==|=========|===== =======|=========
CONSENSUS IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIIVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMLR
Q5VYU3_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ2_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
Q5VYU5_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
Q5VYU4_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ2_MOUSE IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ2_RAT IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ3_MOUSE TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_RAT TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_HUMAN TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_BOVIN TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
Q5VVP3_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_HUMAN IVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
Q5UAX1_COLLI TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
Q5BN39_COLLI FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_RAT IVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
KCNQ5_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_MOUSE IVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
Q5VYU2_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ4_HUMAN FVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVR
KCNQ1_SQUAC IVLVVFFGTEYIVRLWSAGCRSKYVGFWGRLRFARKPISIIDLIVVVASVIVLCVGSNGQVFATSAIRGIRFLQILRMLH
Q967F8_CAEEL IVFVIWLATEYICRVWSAGCRSRYRGISGRIRFATSAYCVIDIIVILASITVLCIGATGQVFAASAIRGLRFFQILRMLR
Q60SW1_CAEBR IFLVIFFAIEYVVRLWSAGCRSKYIGFWGRLKFARKPISFIDLCVVLASFTVICFGSEGQVFATSAIRGIRFLQILRMLH
Q86W40_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
460 550 560
| ==|=========|=====
CONSENSUS MDRRGGTWKLLGSVVYAHSKELITAWYIGFLCLILSSFLVYLAEKDAVGEEGNDEFDTYADALWWGLITLTTIGYGDKTP
Q5VYU3_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ2_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
Q5VYU5_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
Q5VYU4_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ2_MOUSE MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ2_RAT MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ3_MOUSE MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP
KCNQ3_RAT MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP
KCNQ3_HUMAN MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP
KCNQ3_BOVIN MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP
Q5VVP3_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_HUMAN VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVP
Q5UAX1_COLLI MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaNGVEMKEEFETYADALWWGLITLATIGYGDKTP
Q5BN39_COLLI MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NNQFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_RAT VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVP
KCNQ5_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_MOUSE VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVP
Q5VYU2_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ4_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDA.....NSDFSSYADSLWWGTITLTTIGYGDKTP
KCNQ1_SQUAC VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVDDSGSQQFGSYADALWWGVVTVTTIGYGDKVP
Q967F8_CAEEL IDRRAGTWKLLGSVVWAHRQELLTTVYIGFLGLIFSSFLVYLCEKNT.....NDKYQTFADALWWGVITLSTVGYGDKTP
Q60SW1_CAEBR VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDHVGIDGRQAFTSYADALWWGVITMTTIGYGDVVP
Q86W40_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
650 660
=======|=========|=
CONSENSUS QTWNGRLLAATFSLIGVSFFALPAGILGSGFALKVQEQHRQKHFKRRNPAAAGLIQSAWRFYATNRTDVATWKYYERTVT
Q5VYU3_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ2_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
Q5VYU5_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
Q5VYU4_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ2_MOUSE QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRPKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ2_RAT QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ3_MOUSE KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrLdvATWRFYESVVS
KCNQ3_RAT KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrLdvATWRFYESVVS
KCNQ3_HUMAN KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESVVS
KCNQ3_BOVIN KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESVVS
Q5VVP3_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
KCNQ1_HUMAN QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAP
Q5UAX1_COLLI KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESIVS
Q5BN39_COLLI LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AASLIQCVWRSYAADEKSvaTWK.......
KCNQ1_RAT QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPA
KCNQ5_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
KCNQ1_MOUSE QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSATWKIYVRKPA
Q5VYU2_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ4_HUMAN HTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRMP.AANLIQAAWRLYSTDMslTATWYYYDSILp
KCNQ1_SQUAC QTWIGRTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTSWRCHAAENHESATWKMYVRQPT
Q967F8_CAEEL ETWPGKIIAAFCALLGISFFALPAGILGSGFALKVQQHQRQKHLIRRRVPAAKLIQCLWRHyaPESTSLATWKIHLAREL
Q60SW1_CAEBR QTWMGRIVASCFSIFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAATLIQCLWRCHAAEKRISATWNAHID.PL
Q86W40_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
CONSENSUS VPMFRLIPPLNQKKLLRNLKSKSGLRKDNTFSSPRGVLNVGKISPQPQTDRRSADQSLEGSPSKVRKSWSFGDRSRGAFS
Q5VYU3_HUMAN VPMYRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ2_HUMAN VPmsRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
Q5VYU5_HUMAN VPMYRLIPPLNQLELLRNLKSKSGlrKDPPPesPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
Q5VYU4_HUMAN VPmsRLIPPLNQLELLRNLKSKSGlrKDPPPesPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ2_MOUSE VPMYRLIPPLNQLELLRNLKSKSGLtkDRVFSSPRGMAAKGKGSPQAQTVRRsaDQSLDDSPSKVPKSWSFGDRSrgAAS
KCNQ2_RAT VPmsRLIPPLNQLEMLRNLKSKSGLtkDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLDDSPSKVPKSWSFGDRSrgAAS
KCNQ3_MOUSE FPFFrlEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW
KCNQ3_RAT FPFFrlEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW
KCNQ3_HUMAN FPFFrlEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW
KCNQ3_BOVIN FPFFrlDPAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGSNNKER.FRTAFRMKAYAFW
Q5VVP3_HUMAN PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRstDITAEGSPTKVQKSWSflKSSQPKPV
KCNQ1_HUMAN RSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
Q5UAX1_COLLI FPFFrlDGTASQKLGLLDRVR.....GTNTKGKLFTPLNVDAIEESPSKE.....PKNVVLNNKER.FRTAFRMKAYAFW
Q5BN39_COLLI PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKNRQSSVGDRRsaDIATEGSPTKVQKSWSflKSSQPKPV
KCNQ1_RAT RSHTLLSPSPKPKKSVMVKKKKFKLDKDNGLSPGEKIFNVPHITCDPPEDRRPDHFSIDGYDSSVRKSPTLLEVSTPHFL
KCNQ5_HUMAN PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRstDITAEGSPTKVQKSWSflKSSQPKPV
KCNQ1_MOUSE RSHTLLSPSPKPKKSVMVKKKKFKLDKDNGMSPGEKMFNVPHITYDPPEDRRPDHFSIDGYDSSVRKSPTLLELSTPHFL
Q5VYU2_HUMAN VPMYRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ4_HUMAN rELALLfpVPDGAPSRYPPVATCHRPGSTSFCPGEsmGIKDRIRMGSSQRrqLAPPTMPTSPskVQKSWSffRASLRLKP
KCNQ1_SQUAC .KFYVASPSPKTKKSVGKRKKL.KTDKDNGLNS.EKSLNVPNITYDHvdDRKFENSNIDGYDSSVKKSLGILDVNSGALS
Q967F8_CAEEL PPIVKLTPNGsiNRLRQSTKRTPNLNNQNLaqATSKNLSVPriSLVSTSDISEIEQLGALGFSLGWKSKSKYGGSKKavL
Q60SW1_CAEBR AHETKETHHGHSKKHQQSSDDNNVTRKRQLFKKQSSLVNTFRRKGSPSADVEMGGINheRLLRQERGSDTDDEKRVYRIG
Q86W40_HUMAN PHLKALHTCSPTKKEQGEASSRFVISLLLHVCL...............................................
CONSENSUS RQNSEAGSLDGEDEVGDDKDCPCEDLTEDLKAGIKVIRIMQFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLSRIKSLQ
Q5VYU3_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ2_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
Q5VYU5_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
Q5VYU4_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ2_MOUSE RQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ2_RAT RQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ3_MOUSE QSSEDAGTGDPMAerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
KCNQ3_RAT QSSEDAGTGDPMTerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
KCNQ3_HUMAN QSSEDAGTGDPMAerGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
KCNQ3_BOVIN QSSEDAGTGDPTAerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
Q5VVP3_HUMAN IDADTagTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_HUMAN RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
Q5UAX1_COLLI QSSEDAGTgpIAEERGDSSDFLMEDMIPTFKTAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
Q5BN39_COLLI VDADtlGTDDVYDDKGCQCDVSVEDLTPALKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_RAT RTNSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
KCNQ5_HUMAN IDADTagTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_MOUSE RTNSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
Q5VYU2_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ4_HUMAN RTseDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQ
KCNQ1_SQUAC RANSYADDLdiEGEPVLAPITHVSQLRESHRVTVKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
Q967F8_CAEEL QSRMLAPslDEEEAVGYQPQT.IEEFTPALKNCVRAIRRIQLLVARKKFKEALKPYDVKDVIEQYSAGHVDLQSRVKTVQ
Q60SW1_CAEBR TDIEIeeTEEANTPTKLRPDTHIShlTEAHRNAIRAIRKVKYFVARRRFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQ
Q86W40_HUMAN ................................................................................
CONSENSUS SRVDQIVGKPSTFTKDSEKGPAEAELTEDPSMMGREGKVEDMDQKLDFLVDMLKQLDFLVNIYMPRMGIPPAETEAYEDN
Q5VYU3_HUMAN SRIDMIVGPPPPStkDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
KCNQ2_HUMAN SRVDQIVggPAITDKDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
Q5VYU5_HUMAN SRIDMIVGPPPPStkDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
Q5VYU4_HUMAN SRVDQIVggPAITDKDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
KCNQ2_MOUSE SRIDMIVGPPPPStkDRTKGPAETELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVSIYTQRMGIPPAETEAY...
KCNQ2_RAT SRVDQIVggPTITDKDRTKGPAETELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVSIYTQRMGIPPAETEAY...
KCNQ3_MOUSE TRIDMipGPPStfTYPSQQSPRNEPYVARAATskVERQVHDMGKKLDFLVDMHMqlQVHVTEYYPTKGASsaEGEKKEDN
KCNQ3_RAT TRIDMipGPPStfTYPSQQSPRNEPYVARAATskVERQVHDMGKKLDFLVDMHMqlQVHVTEYYPTKGASsaEGEKKEDN
KCNQ3_HUMAN TRIDMipGPPStfTFPSQQSPRNEPYVARPSTskVERQVQDMGKKLDFLVDMHMqlQVQVTEYYPTKGTspAEAEKKEDN
KCNQ3_BOVIN TRIDMipGPPStfTYPSQQSPRNEPYVARPSTskVERQVHDMGKKLDFLVDMHLqlQVHVAGFSPSKGASsaEAEQKEDR
Q5VVP3_HUMAN TRVDQILGKgtSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFE
KCNQ1_HUMAN RRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQ
Q5UAX1_COLLI ARVDMipGPPStfSYPSQQSPRNDPYVAKASTakVERQVNDMGKKLDFLVDMHmqLQIQVTEISPLKETASPAKEKREEN
Q5BN39_COLLI SRVDQILGKgtADKRSREKNPAENETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLASFQMPAFE
KCNQ1_RAT RRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSL.......QQGGPTCNNRSQVV
KCNQ5_HUMAN TRVDQILGKgtSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFE
KCNQ1_MOUSE RRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSM.......QQGGPTCNSRSQVV
Q5VYU2_HUMAN srLPVQQgkPTVAHGGSAGGVWAGP.PPHPRRPLSASVVS..SQSLF.................................
KCNQ4_HUMAN TRVDQIVGRGPGDRKARekGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRstSASLGAVQVPLFDPDI
KCNQ1_SQUAC RRLDQSLGKPTMFLSVSEKSQDRGKNTIGARLNRVEEKFVHMDQKLNTITDMLHHLVAHQQGHPHPQTQPQAQGTVVQAV
Q967F8_CAEEL AKLDFICGKN......IEKIEPKISMFTRIATL..ETTVGKMDKKLDLMVEMLmqRVFSQNTSPRGEFSEPTSARQDLTR
Q60SW1_CAEBR RRLDQTLGKPgyDGKGSRKG...HPVTIGSRLSRLELQMSSLDRKVESSNRTLSALYRLMVDRNSLTISPSPPALMSRPV
Q86W40_HUMAN ................................................................................
CONSENSUS RYSDFGAIEPEPAPPSHSLPEYSQEHVDRHGPIGKI
Q5VYU3_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
KCNQ2_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
Q5VYU5_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
Q5VYU4_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
KCNQ2_MOUSE ....FGAKEPEPAPPYHS.PEDSRDHADKHGCIIKI............................................
KCNQ2_RAT ....FGAKEPEPAPPYHS.PEDSRDHADKHGCIIKI............................................
KCNQ3_MOUSE RYSDLKTIICNYSETGPPDPPYSFHQVprVGPYGFF............................................
KCNQ3_RAT RYSDLKTIICNYSESGPPDPPYSFHQVprVGPYGFF............................................
KCNQ3_HUMAN RYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYG............................................
KCNQ3_BOVIN RDADLKTIICNYSETGAPDAPYsqVPVDKVGPYGFF............................................
Q5VVP3_HUMAN CEQTSDYQSPVD...SKDLSGSAQNSGCLSRSTSAN............................................
KCNQ1_HUMAN PCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS............................................
Q5UAX1_COLLI KYSELKTIIYKYTGQCHETPYNfqVPVNKVSPYGFS............................................
Q5BN39_COLLI CEQTSDYQSPSD...SKDLSNSSQMSGCVPRSASAN............................................
KCNQ1_RAT ASDERGSINPELFLPSNSLPTYEQLTVPQTGPDEGS............................................
KCNQ5_HUMAN CEQTSDYQSPVD...SKDLSGSAQNSGCLSRSTSAN............................................
KCNQ1_MOUSE ASNEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS............................................
Q5VYU2_HUMAN ................................................................................
KCNQ4_HUMAN TSDYHSPVDHEDISVSAQTLSISRSVSTNMD.................................................
KCNQ1_SQUAC ............ASTHSSLPSYEQLTVRRKDQDNQP............................................
Q967F8_CAEEL SRRSMVSTDMEMYTARSHSPGYHGDARPIIAQIDAD............................................
Q60SW1_CAEBR SPANCLSPRDQLSPTSISSQRssYTLDPNGGWH...............................................
Q86W40_HUMAN ................................................................................
The top layer shows the consensus sequence. Residues are coloured after their physico-chemical properties. (GPX black; positive blue; negative red; CM yellow; H dark purple; NQ light purple; all others green).