2005, KChannelDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
CONSENSUS MAGLSSPPMAQKSRNGGGVYPGAGSGEKKLAVGFVGLDPGAEDSTGDGALLAEQVTLALGGGGIAGSEAPKRGSGASEGG
Q5VYU3_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ2_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
Q5VYU5_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
Q5VYU4_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ2_MOUSE ........MVQKSRNG.GVYPG.TSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSVLS..K
KCNQ2_RAT ........MVQKSRNG.GVYPG.TSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSVLS..K !
KCNQ3_MOUSE .MGLKARTAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGREEGQ
KCNQ3_RAT .MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGTGADKDGTLLLEGGGREEGQ !
KCNQ3_HUMAN ..MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQ
KCNQ3_BOVIN ..MGLKARRPAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQ
Q5VVP3_HUMAN AAGLWVKSGAAAAAAGGGRL...GSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
KCNQ1_HUMAN MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLG !
Q5UAX1_COLLI ..............MGLKARRGAAGGSA...AGGAAAAAAGRRGTASGVGDPEQGSLALGTGADRDGTLLLEGGGKEEGG
Q5BN39_COLLI ......MGDAMPRNHGGGEEGGSAGLWMKSGATAGMKDVESGRGRALASGSARGDGLLLLGTGGAAAPAGLREGRRGKHG
KCNQ1_RAT MDTASSPPNAERKRAGWGRLLGARRGSAGLAKKCPFSLELAEGGPTGGTVYAPIatGAPGLAPPMSPPVSPVPAPAD.LG
KCNQ5_HUMAN ..........................MKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
KCNQ1_MOUSE MDTASSPPSAERKRAGWSRLLGARRGSAVVK.KCPFSLELAEGGPEGSTVYAPIatGAPGLAPPMSTPVSPAPAPAD.LG !
Q5VYU2_HUMAN ........MVQKSRNG.GVYPG.PSGEKKLKVGFVGLDPGAPDSTRDGALL............IAGSEAPKRGSILS..K
KCNQ4_HUMAN ......MAEAPPRRLGLGPPPGDAPRAELVALTAVQ....SEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG !
KCNQ1_SQUAC ...........MSSEVKSRWSGSGSQKSGTARKPTMlaENAASRHYEPVPLPLQRSNSPDSSTDKNPESRAADSRAeiNP
Q967F8_CAEEL ....................MDEESGSSTDQAAPSDEQQEAGSSSAIGQESRKTVVFQEPDIGFPSEHDQLTTLHDSEEG
Q60SW1_CAEBR .....................................................MLTTTGYPNGSSLVDDSPQDQDESEHF
Q86W40_HUMAN AAGLWVKSGAAAAAAGGGRL...GSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSL
140 150
==|=========|====== ===
CONSENSUS PRTPLSAGGAGSGKPPRRNAFYRRRLQNFLYNVLERPRGWKAFIYHAYVFLLVFGCLILSVFSTIKEYEKLSEGALLILE
Q5VYU3_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
Q5VYU5_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
Q5VYU4_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_MOUSE PRT....GGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ2_RAT PRT....GGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ3_MOUSE RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
KCNQ3_RAT RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE !
KCNQ3_HUMAN RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE !
KCNQ3_BOVIN RRTPQGIGLLAKTPLSrrNNAKYRRIQTLIYDALERPRGW.ALLYHALVFLIVLGCLILAVLTTFREYETVSGDWLLLLE
Q5VVP3_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
KCNQ1_HUMAN PRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWME !
Q5UAX1_COLLI KRSPPGLGLLAKTPLSrrNHAKYRRIQTLIYDALERPRGW.ALLYHAFVFLIVLGCLILAVLTTFKEYETVSGDWLLLLE
Q5BN39_COLLI ARMSLLGKPLSygPSCRRNAKYR.RLQNYLYNVLERPRGW.AFVYHAFVFLLVFGCLILSVFSTIPEHTKLASGCLFILE
KCNQ1_RAT PRPRVSLDPRVSIYSTRRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
KCNQ5_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
KCNQ1_MOUSE PRPRVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
Q5VYU2_HUMAN PR....AGGAGAGKPPKRNAFYR.KLQNFLYNVLERPRGW.AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE
KCNQ4_HUMAN QR.........SSAAHKR....YRRLQNWVYNVLERPRGW.AFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILE
KCNQ1_SQUAC DIPPKAIALPLSRYRGRNPFFSKVNIQGRTYNFLERPTGWKCFIYHFTVFLIVLVCLIFSVMSTIEQYHYFANRALVWME
Q967F8_CAEEL NRKM.SLVGKPLTYKNYRTDQRFRRMQNKMHNFLERPRGWKAATYHLAVLFMVLMCLALSVFSTMPDFEVNATIVLYYLE
Q60SW1_CAEBR LLGMVTGDGLGKMFNArrNiaAKMTYRALIYNCLERPTGWKCFLYHFSVFLVVLICLILSVLSTVEEHSHFAAELLYILE
Q86W40_HUMAN LGKPLS...YTSSQSCRRNVKYR.RVQNYLYNVLERPRGW.AFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILE
250 340 350 450
======|======== ==|=========|===== =======|=========
CONSENSUS IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIIVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMLR
Q5VYU3_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ2_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR !
Q5VYU5_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
Q5VYU4_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ2_MOUSE IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR !
KCNQ2_RAT IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR !
KCNQ3_MOUSE TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_RAT TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_HUMAN TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
KCNQ3_BOVIN TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
Q5VVP3_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_HUMAN IVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH !
Q5UAX1_COLLI TFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS.LRSLRFLQILRMLR
Q5BN39_COLLI FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_RAT IVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
KCNQ5_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR
KCNQ1_MOUSE IVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
Q5VYU2_HUMAN IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIR
KCNQ4_HUMAN FVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVR
KCNQ1_SQUAC IVLVVFFGTEYIVRLWSAGCRSKYVGFWGRLRFARKPISIIDLIVVVASVIVLCVGSNGQVFATSAIRGIRFLQILRMLH
Q967F8_CAEEL IVFVIWLATEYICRVWSAGCRSRYRGISGRIRFATSAYCVIDIIVILASITVLCIGATGQVFAASAIRGLRFFQILRMLR
Q60SW1_CAEBR IFLVIFFAIEYVVRLWSAGCRSKYIGFWGRLKFARKPISFIDLCVVLASFTVICFGSEGQVFATSAIRGIRFLQILRMLH
Q86W40_HUMAN FVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVR !
460 550 560
| ==|=========|=====
CONSENSUS MDRRGGTWKLLGSVVYAHSKELITAWYIGFLCLILSSFLVYLAEKDAVGEEGNDEFDTYADALWWGLITLTTIGYGDKTP
Q5VYU3_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ2_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP !
Q5VYU5_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
Q5VYU4_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ2_MOUSE MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP !
KCNQ2_RAT MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP !
KCNQ3_MOUSE MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP !
KCNQ3_RAT MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP !
KCNQ3_HUMAN MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP !
KCNQ3_BOVIN MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaQGEEMKEEFETYADALWWGLITLATIGYGDKTP
Q5VVP3_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_HUMAN VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVP !
Q5UAX1_COLLI MDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKdaNGVEMKEEFETYADALWWGLITLATIGYGDKTP
Q5BN39_COLLI MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NNQFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_RAT VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVP !
KCNQ5_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
KCNQ1_MOUSE VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVP
Q5VYU2_HUMAN MDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEK...GE..NDHFDTYADALWWGLITLTTIGYGDKYP
KCNQ4_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDA.....NSDFSSYADSLWWGTITLTTIGYGDKTP !
KCNQ1_SQUAC VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVDDSGSQQFGSYADALWWGVVTVTTIGYGDKVP
Q967F8_CAEEL IDRRAGTWKLLGSVVWAHRQELLTTVYIGFLGLIFSSFLVYLCEKNT.....NDKYQTFADALWWGVITLSTVGYGDKTP
Q60SW1_CAEBR VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDHVGIDGRQAFTSYADALWWGVITMTTIGYGDVVP
Q86W40_HUMAN MDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDA.....NKEFSTYADALWWGTITLTTIGYGDKTP
650 660
=======|=========|=
CONSENSUS QTWNGRLLAATFSLIGVSFFALPAGILGSGFALKVQEQHRQKHFKRRNPAAAGLIQSAWRFYATNRTDVATWKYYERTVT
Q5VYU3_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ2_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT !
Q5VYU5_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
Q5VYU4_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ2_MOUSE QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRPKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT !
KCNQ2_RAT QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ3_MOUSE KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrLdvATWRFYESVVS
KCNQ3_RAT KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrLdvATWRFYESVVS !
KCNQ3_HUMAN KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESVVS
KCNQ3_BOVIN KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESVVS
Q5VVP3_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
KCNQ1_HUMAN QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAP !
Q5UAX1_COLLI KTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHfkRRKP.AAELIQAAWRYYATnrIdvATWRFYESIVS
Q5BN39_COLLI LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AASLIQCVWRSYAADEKSvaTWK.......
KCNQ1_RAT QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPA
KCNQ5_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
KCNQ1_MOUSE QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSATWKIYVRKPA
Q5VYU2_HUMAN QTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AAGLIQSAWRFYATnrTdhSTWQYYERTVT
KCNQ4_HUMAN HTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRMP.AANLIQAAWRLYSTDMslTATWYYYDSILp
KCNQ1_SQUAC QTWIGRTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTSWRCHAAENHESATWKMYVRQPT
Q967F8_CAEEL ETWPGKIIAAFCALLGISFFALPAGILGSGFALKVQQHQRQKHLIRRRVPAAKLIQCLWRHyaPESTSLATWKIHLAREL
Q60SW1_CAEBR QTWMGRIVASCFSIFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAATLIQCLWRCHAAEKRISATWNAHID.PL
Q86W40_HUMAN LTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHfkRRNP.AANLIQCVWRSYAADEKSvaTWK.......
CONSENSUS VPMFRLIPPLNQKKLLRNLKSKSGLRKDNTFSSPRGVLNVGKISPQPQTDRRSADQSLEGSPSKVRKSWSFGDRSRGAFS
Q5VYU3_HUMAN VPMYRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ2_HUMAN VPmsRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS !
Q5VYU5_HUMAN VPMYRLIPPLNQLELLRNLKSKSGlrKDPPPesPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
Q5VYU4_HUMAN VPmsRLIPPLNQLELLRNLKSKSGlrKDPPPesPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ2_MOUSE VPMYRLIPPLNQLELLRNLKSKSGLtkDRVFSSPRGMAAKGKGSPQAQTVRRsaDQSLDDSPSKVPKSWSFGDRSrgAAS !
KCNQ2_RAT VPmsRLIPPLNQLEMLRNLKSKSGLtkDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLDDSPSKVPKSWSFGDRSrgAAS
KCNQ3_MOUSE FPFFrlEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW
KCNQ3_RAT FPFFrlEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW
KCNQ3_HUMAN FPFFrlEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGLNNKER.FRTAFRMKAYAFW !
KCNQ3_BOVIN FPFFrlDPAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKE.....PKPVGSNNKER.FRTAFRMKAYAFW
Q5VVP3_HUMAN PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRstDITAEGSPTKVQKSWSflKSSQPKPV
KCNQ1_HUMAN RSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM !
Q5UAX1_COLLI FPFFrlDGTASQKLGLLDRVR.....GTNTKGKLFTPLNVDAIEESPSKE.....PKNVVLNNKER.FRTAFRMKAYAFW
Q5BN39_COLLI PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKNRQSSVGDRRsaDIATEGSPTKVQKSWSflKSSQPKPV
KCNQ1_RAT RSHTLLSPSPKPKKSVMVKKKKFKLDKDNGLSPGEKIFNVPHITCDPPEDRRPDHFSIDGYDSSVRKSPTLLEVSTPHFL
KCNQ5_HUMAN PHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRstDITAEGSPTKVQKSWSflKSSQPKPV
KCNQ1_MOUSE RSHTLLSPSPKPKKSVMVKKKKFKLDKDNGMSPGEKMFNVPHITYDPPEDRRPDHFSIDGYDSSVRKSPTLLELSTPHFL
Q5VYU2_HUMAN VPMYRLIPPLNQLELLRNLKSKSGLakDRVFSSPRGVAAKGKGSPQAQTVRRsaDQSLEDSPSKVPKSWSFGDRSrgAAS
KCNQ4_HUMAN rELALLfpVPDGAPSRYPPVATCHRPGSTSFCPGEsmGIKDRIRMGSSQRrqLAPPTMPTSPskVQKSWSffRASLRLKP !
KCNQ1_SQUAC .KFYVASPSPKTKKSVGKRKKL.KTDKDNGLNS.EKSLNVPNITYDHvdDRKFENSNIDGYDSSVKKSLGILDVNSGALS
Q967F8_CAEEL PPIVKLTPNGsiNRLRQSTKRTPNLNNQNLaqATSKNLSVPriSLVSTSDISEIEQLGALGFSLGWKSKSKYGGSKKavL
Q60SW1_CAEBR AHETKETHHGHSKKHQQSSDDNNVTRKRQLFKKQSSLVNTFRRKGSPSADVEMGGINheRLLRQERGSDTDDEKRVYRIG
Q86W40_HUMAN PHLKALHTCSPTKKEQGEASSRFVISLLLHVCL...............................................
CONSENSUS RQNSEAGSLDGEDEVGDDKDCPCEDLTEDLKAGIKVIRIMQFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLSRIKSLQ
Q5VYU3_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ2_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ !
Q5VYU5_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
Q5VYU4_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ2_MOUSE RQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ !
KCNQ2_RAT RQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ !
KCNQ3_MOUSE QSSEDAGTGDPMAerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
KCNQ3_RAT QSSEDAGTGDPMTerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ !
KCNQ3_HUMAN QSSEDAGTGDPMAerGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
KCNQ3_BOVIN QSSEDAGTGDPTAerGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
Q5VVP3_HUMAN IDADTagTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_HUMAN RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ !
Q5UAX1_COLLI QSSEDAGTgpIAEERGDSSDFLMEDMIPTFKTAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
Q5BN39_COLLI VDADtlGTDDVYDDKGCQCDVSVEDLTPALKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_RAT RTNSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
KCNQ5_HUMAN IDADTagTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
KCNQ1_MOUSE RTNSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
Q5VYU2_HUMAN RQNSEEASLPGEDIV.DDKSCPCEFVTEDLTPGLKvirvMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQ
KCNQ4_HUMAN RTseDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQ !
KCNQ1_SQUAC RANSYADDLdiEGEPVLAPITHVSQLRESHRVTVKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQ
Q967F8_CAEEL QSRMLAPslDEEEAVGYQPQT.IEEFTPALKNCVRAIRRIQLLVARKKFKEALKPYDVKDVIEQYSAGHVDLQSRVKTVQ
Q60SW1_CAEBR TDIEIeeTEEANTPTKLRPDTHIShlTEAHRNAIRAIRKVKYFVARRRFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQ
Q86W40_HUMAN ................................................................................
CONSENSUS SRVDQIVGKPSTFTKDSEKGPAEAELTEDPSMMGREGKVEDMDQKLDFLVDMLKQLDFLVNIYMPRMGIPPAETEAYEDN
Q5VYU3_HUMAN SRIDMIVGPPPPStkDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
KCNQ2_HUMAN SRVDQIVggPAITDKDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
Q5VYU5_HUMAN SRIDMIVGPPPPStkDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
Q5VYU4_HUMAN SRVDQIVggPAITDKDRTKGPAEAELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVNIYMQRMGIPPTETEAY...
KCNQ2_MOUSE SRIDMIVGPPPPStkDRTKGPAETELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVSIYTQRMGIPPAETEAY... !
KCNQ2_RAT SRVDQIVggPTITDKDRTKGPAETELPEDPSMMGRLGKVE..KQVL....SMEKKLDFLVSIYTQRMGIPPAETEAY...
KCNQ3_MOUSE TRIDMipGPPStfTYPSQQSPRNEPYVARAATskVERQVHDMGKKLDFLVDMHMqlQVHVTEYYPTKGASsaEGEKKEDN
KCNQ3_RAT TRIDMipGPPStfTYPSQQSPRNEPYVARAATskVERQVHDMGKKLDFLVDMHMqlQVHVTEYYPTKGASsaEGEKKEDN
KCNQ3_HUMAN TRIDMipGPPStfTFPSQQSPRNEPYVARPSTskVERQVQDMGKKLDFLVDMHMqlQVQVTEYYPTKGTspAEAEKKEDN
KCNQ3_BOVIN TRIDMipGPPStfTYPSQQSPRNEPYVARPSTskVERQVHDMGKKLDFLVDMHLqlQVHVAGFSPSKGASsaEAEQKEDR
Q5VVP3_HUMAN TRVDQILGKgtSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFE
KCNQ1_HUMAN RRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQ !
Q5UAX1_COLLI ARVDMipGPPStfSYPSQQSPRNDPYVAKASTakVERQVNDMGKKLDFLVDMHmqLQIQVTEISPLKETASPAKEKREEN
Q5BN39_COLLI SRVDQILGKgtADKRSREKNPAENETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLASFQMPAFE
KCNQ1_RAT RRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSL.......QQGGPTCNNRSQVV
KCNQ5_HUMAN TRVDQILGKgtSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFE
KCNQ1_MOUSE RRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSM.......QQGGPTCNSRSQVV
Q5VYU2_HUMAN srLPVQQgkPTVAHGGSAGGVWAGP.PPHPRRPLSASVVS..SQSLF.................................
KCNQ4_HUMAN TRVDQIVGRGPGDRKARekGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRstSASLGAVQVPLFDPDI
KCNQ1_SQUAC RRLDQSLGKPTMFLSVSEKSQDRGKNTIGARLNRVEEKFVHMDQKLNTITDMLHHLVAHQQGHPHPQTQPQAQGTVVQAV
Q967F8_CAEEL AKLDFICGKN......IEKIEPKISMFTRIATL..ETTVGKMDKKLDLMVEMLmqRVFSQNTSPRGEFSEPTSARQDLTR
Q60SW1_CAEBR RRLDQTLGKPgyDGKGSRKG...HPVTIGSRLSRLELQMSSLDRKVESSNRTLSALYRLMVDRNSLTISPSPPALMSRPV
Q86W40_HUMAN ................................................................................
CONSENSUS RYSDFGAIEPEPAPPSHSLPEYSQEHVDRHGPIGKI
Q5VYU3_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
KCNQ2_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................ !
Q5VYU5_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
Q5VYU4_HUMAN ....FGAKEPEPAPPYHS.PEDSREHVDRHGCIVKI............................................
KCNQ2_MOUSE ....FGAKEPEPAPPYHS.PEDSRDHADKHGCIIKI............................................ !
KCNQ2_RAT ....FGAKEPEPAPPYHS.PEDSRDHADKHGCIIKI............................................
KCNQ3_MOUSE RYSDLKTIICNYSETGPPDPPYSFHQVprVGPYGFF............................................
KCNQ3_RAT RYSDLKTIICNYSESGPPDPPYSFHQVprVGPYGFF............................................
KCNQ3_HUMAN RYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYG............................................
KCNQ3_BOVIN RDADLKTIICNYSETGAPDAPYsqVPVDKVGPYGFF............................................
Q5VVP3_HUMAN CEQTSDYQSPVD...SKDLSGSAQNSGCLSRSTSAN............................................
KCNQ1_HUMAN PCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS............................................ !
Q5UAX1_COLLI KYSELKTIIYKYTGQCHETPYNfqVPVNKVSPYGFS............................................
Q5BN39_COLLI CEQTSDYQSPSD...SKDLSNSSQMSGCVPRSASAN............................................
KCNQ1_RAT ASDERGSINPELFLPSNSLPTYEQLTVPQTGPDEGS............................................
KCNQ5_HUMAN CEQTSDYQSPVD...SKDLSGSAQNSGCLSRSTSAN............................................
KCNQ1_MOUSE ASNEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS............................................
Q5VYU2_HUMAN ................................................................................
KCNQ4_HUMAN TSDYHSPVDHEDISVSAQTLSISRSVSTNMD.................................................
KCNQ1_SQUAC ............ASTHSSLPSYEQLTVRRKDQDNQP............................................
Q967F8_CAEEL SRRSMVSTDMEMYTARSHSPGYHGDARPIIAQIDAD............................................
Q60SW1_CAEBR SPANCLSPRDQLSPTSISSQRssYTLDPNGGWH...............................................
Q86W40_HUMAN ................................................................................