KChannelDB Groups of residues showing correlated mutational behaviour
2005, KChannelDB.
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*** ***
*** Files used in the CMA analysis ***
*** ***
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1 : KCNH2_HUMAN 1159 Q12809 KCNH2 -- Potassium voltage-gated channe
2 : KCNH2_RABIT 1161 Q8WNY2 KCNH2 -- Potassium voltage-gated channe
3 : KCNH2_CANFA 1158 Q9TSZ3 KCNH2 -- Potassium voltage-gated channe
4 : KCNH2_RAT 1163 O08962 Kcnh2 -- Potassium voltage-gated channe
5 : KCNH2_MOUSE 1162 O35219 Kcnh2 -- Potassium voltage-gated channe
6 : KCNH7_MOUSE 1195 Q9ER47 Kcnh7 -- Potassium voltage-gated channe
7 : KCNH7_HUMAN 1196 Q9NS40 KCNH7 -- Potassium voltage-gated channe
8 : Q5PXK6_RAT 729 Q5PXK6 Voltage-gated potassium channe
9 : Q8HXV1_RABIT 759 Q8HXV1 KCNC3 -- Shaw type potassium channel Kv
10 : Q8JH78_BRARE 1186 Q8JH78 kcnh2 -- Erg K+ channel.
11 : KCNC3_HUMAN 757 Q14003 KCNC3 -- Potassium voltage-gated channe
12 : Q5PXK5_RAT 730 Q5PXK5 Voltage-gated potassium channe
13 : KCNA4_MUSPF 654 Q28527 KCNA4 -- Potassium voltage-gated channe
14 : KCNC3_RAT 889 Q01956 Kcnc3 -- Potassium voltage-gated channe
15 : KCNA4_MOUSE 654 Q61423 Kcna4 -- Potassium voltage-gated channe
16 : Q5REB6_PONPY 653 Q5REB6 DKFZp45--0Hypothetical protein DKFZp459N
17 : KCNC3_MOUSE 769 Q63959 Kcnc3 -- Potassium voltage-gated channe
18 : Q9YGX8_CHICK 662 Q9YGX8 Potassium channel Shaker cKv1.
19 : KCNA4_HUMAN 653 P22459 KCNA4 -- Potassium voltage-gated channe
20 : Q90W36_COLLI 662 Q90W36 Potassium channel shaker alpha
21 : KCNA4_RAT 655 P15385 Kcna4 -- Potassium voltage-gated channe
22 : O18476_LOLPE 908 O18476 Kv2 voltage-gated potassium ch
23 : Q8CCH4_MOUSE 841 Q8CCH4 Kcnn2 -- Mus musculus 15 days embryo ma
24 : KCNA4_BOVIN 660 Q05037 KCNA4 -- Potassium voltage-gated channe
25 : Q9GLF1_BOVIN 661 Q9GLF1 Voltage-gated K+ channel Kv1.4
26 : KCNAB_DROME 985 P17970 Shab -- Potassium voltage-gated channe
27 : Q7KVW6_DROME 924 Q7KVW6 SK -- CG10706-PF, isoform F.
28 : Q7KVW5_DROME 924 Q7KVW5 SK -- CG10706-PC, isoform C.
29 : Q8JG57_XENLA 697 Q8JG57 Shaker-like potassium channel
30 : Q98TW3_XENLA 677 Q98TW3 Kv1.4 potassium channel.
31 : Q26344_APLSP 905 Q26344 Shab -- Action potential broadening po
32 : Q96DJ3_HUMAN 737 Q96DJ3 KCNN3 -- Small-conductance calcium-acti
33 : Q9Z1R6_MOUSE 602 Q9Z1R6 Kcna5 -- Ventricular potassium channel
34 : KCNN3_HUMAN 736 Q9UGI6 KCNN3 -- Small conductance calcium-acti
35 : KCNAS_DROME 656 Q9VWZ5 Sh -- Potassium voltage-gated channe
36 : KCNA5_RAT 602 P19024 Kcna5 -- Potassium voltage-gated channe
37 : Q5RDT9_PONPY 630 Q5RDT9 DKFZp45--1Hypothetical protein DKFZp459P
38 : KCND2_RAT 630 Q63881 Kcnd2 -- Potassium voltage-gated channe
39 : KCNN3_RAT 732 P70605 Kcnn3 -- Small conductance calcium-acti
40 : KCNA5_MOUSE 602 Q61762 Kcna5 -- Potassium voltage-gated channe
41 : Q8UW33_CHICK 632 Q8UW33 kv4.2 -- Shal-like voltage-gated potass
42 : Q8WN02_MUSPF 655 Q8WN02 Voltage-gated potassium channe
43 : KCNN3_MOUSE 731 P58391 Kcnn3 -- Small conductance calcium-acti
44 : KCNB1_RAT 857 P15387 Kcnb1 -- Potassium voltage-gated channe
45 : Q80X33_MOUSE 771 Q80X33 Kcnb1 -- Kcnb1 protein.
46 : Q9PTD3_CHICK 658 Q9PTD3 KCND3 -- Potassium channel Kv4.3.
47 : KCND3_MOUSE 655 Q9Z0V1 Kcnd3 -- Potassium voltage-gated channe
48 : KCNB1_RABIT 858 Q9MZ19 KCNB1 -- Potassium voltage-gated channe
49 : KCNB1_HUMAN 858 Q14721 KCNB1 -- Potassium voltage-gated channe
50 : KCNA5_MUSPF 601 P79197 KCNA5 -- Potassium voltage-gated channe
51 : Q95PC7_PANIN 660 Q95PC7 shal1 -- Potassium channel protein Shal
52 : KCNN3_PIG 724 P58392 KCNN3 -- Small conductance calcium-acti
53 : Q56G64_BOVIN 598 Q56G64 KCNA5 -- Potassium voltage-gated channe
54 : Q866G0_CANFA 600 Q866G0 KCNA5 -- Delayed rectifier K+ channel.
55 : KCNA5_RABIT 598 P50638 KCNA5 -- Potassium voltage-gated channe
56 : KCNA5_HUMAN 613 P22460 KCNA5 -- Potassium voltage-gated channe
57 : Q9TS07_BOVIN 597 Q9TS07 BAK5=DELAYED rectifier potassi
58 : Q7T195_CHICK 580 Q7T195 Shaker subfamily potassium cha
59 : Q5USC2_PIG 600 Q5USC2 kcna5 -- Potassium voltage-gated channe
60 : KCNB2_RABIT 911 Q95L11 KCNB2 -- Potassium voltage-gated channe
61 : KCNB2_RAT 907 Q63099 Kcnb2 -- Potassium voltage-gated channe
62 : Q7Z7D0_HUMAN 911 Q7Z7D0 Voltage-gated potassium channe
63 : Q95PC5_PANIN 579 Q95PC5 shal1 -- Potassium channel protein Shal
64 : Q5VWN2_HUMAN 575 Q5VWN2 KCNA3 -- Potassium voltage-gated channe
65 : Q91593_XENLA 876 Q91593 XShab9 -- Potassium channel alpha subuni
66 : Q95PC6_PANIN 680 Q95PC6 shal1 -- Potassium channel protein Shal
67 : Q5T0M1_HUMAN 636 Q5T0M1 KCND3 -- Potassium voltage-gated channe
68 : Q95PC3_PANIN 608 Q95PC3 shal1 -- Potassium channel protein Shal
69 : Q9VX00_DROME 616 Q9VX00 Sh -- CG12348-PB, isoform B (Cg12348
70 : Q7ZW36_BRARE 638 Q7ZW36 ORFName--zPotassium voltage-gated channe
71 : KCNC4_HUMAN 635 Q03721 KCNC4 -- Potassium voltage-gated channe
72 : Q91592_XENLA 898 Q91592 XShab12-- Potassium channel alpha subuni
73 : Q96PR1_HUMAN 638 Q96PR1 KCNC2 -- Voltage gated potassium channe
74 : KCNC4_RAT 625 Q63734 Kcnc4 -- Potassium voltage-gated channe
75 : Q5VSI1_BRARE 630 Q5VSI1 OTTDARP--0Novel protein similar to verte
76 : O57662_XENLA 659 O57662 Potassium channel xKv4.3.
77 : KCNC2_RAT 638 P22462 Kcnc2 -- Potassium voltage-gated channe
78 : Q9DDN7_9TELE 651 Q9DDN7 Kv3.3 potassium channel subuni
79 : KCND1_MOUSE 651 Q03719 Kcnd1 -- Potassium voltage-gated channe
80 : KCND1_HUMAN 647 Q9NSA2 KCND1 -- Potassium voltage-gated channe
81 : Q86W09_HUMAN 629 Q86W09 KCNC2 -- Kv3.2d voltage-gated potassium
82 : Q95PD0_PANIN 551 Q95PD0 shal1 -- Potassium channel protein Shal
83 : KCNH6_RAT 950 O54853 Kcnh6 -- Potassium voltage-gated channe
84 : KCNH6_HUMAN 994 Q9H252 KCNH6 -- Potassium voltage-gated channe
85 : Q8IAD3_HALRO 633 Q8IAD3 TuKv4a -- Kv4 class voltage-gated potass
86 : Q9PVD1_XENLA 592 Q9PVD1 Kv3.1 potassium channel.
87 : Q9XSJ8_CANFA 585 Q9XSJ8 Kv3.1 -- Kv3.1.
88 : Q96PR0_HUMAN 613 Q96PR0 Voltage gated potassium channe
89 : Q6R4N6_CIOIN 800 Q6R4N6 Potassium channel Kv4.
90 : KCNA3_RAT 525 P15384 Kcna3 -- Potassium voltage-gated channe
91 : Q95XD1_CAEEL 609 Q95XD1 Y73B6BL--9Hypothetical protein Y73B6BL.1
92 : KCNA3_MOUSE 528 P16390 Kcna3 -- Potassium voltage-gated channe
93 : Q90ZP4_ONCMY 752 Q90ZP4 Potassium channel TSK3.
94 : Q61U60_CAEBR 581 Q61U60 CBG0546-- Hypothetical protein CBG05460.
95 : Q28649_RABIT 725 Q28649 Kcn1 -- CGMP-gated potassium channel.
96 : Q9IA29_ONCMY 587 Q9IA29 Shaw-related potassium channel
97 : Q8I0I3_CAEEL 589 Q8I0I3 ORFName--FHypothetical protein F14F11.1b
98 : Q95PC9_PANIN 561 Q95PC9 shal1 -- Potassium channel protein Shal
99 : KCNA2_HUMAN 499 P16389 KCNA2 -- Potassium voltage-gated channe
100 : Q6UVM4_RAT 1142 Q6UVM4 Slick -- Sodium-and chloride-activated
101 : Q7JM92_CAEEL 619 Q7JM92 ORFName--FHypothetical protein F14F11.1h
102 : Q6UVM3_HUMAN 1135 Q6UVM3 SLICK -- Sodium-and chloride-activated
103 : Q7T1A0_CHICK 499 Q7T1A0 Shaker subfamily potassium cha
104 : KCNA2_CANFA 499 Q28293 KCNA2 -- Potassium voltage-gated channe
105 : Q28656_RABIT 516 Q28656 Kv1.3-g--bGlibenclamide-sensitive voltag
106 : Q98TW4_XENLA 499 Q98TW4 Kv1.2' potassium channel.
107 : KCNA2_XENLA 499 P22739 Potassium voltage-gated channe
108 : Q8SYL2_DROME 604 Q8SYL2 Shaw -- RE54962p (CG2822-PB, isoform B
109 : Q5VTN1_HUMAN 1111 Q5VTN1 RP11-58--3Sodium-and chloride-activated
110 : O02497_DROME 855 O02497 sei -- CG3182-PA, isoform A (Cg3182-p
111 : Q8CA58_MOUSE 495 Q8CA58 Kcna1 -- Mus musculus adult male spinal
112 : KCNA1_HUMAN 495 Q09470 KCNA1 -- Potassium voltage-gated channe
113 : Q627G3_CAEBR 775 Q627G3 CBG0068-- Hypothetical protein CBG00686.
114 : Q90YY3_XENLA 485 Q90YY3 Kv1.3B -- Shaker-like potassium channel
115 : Q8N1V9_HUMAN 558 Q8N1V9 KCNC2 -- Hypothetical protein FLJ37401
116 : Q91781_XENLA 489 Q91781 Potassium channel.
117 : Q9I830_ONCMY 494 Q9I830 Shaker-related potassium chann
118 : Q9XXX0_HALRO 583 Q9XXX0 TuKvI -- TuKvI.
119 : O61335_PANIN 522 O61335 shaker -- Potassium channel.
120 : Q16968_APLCA 515 Q16968 Potassium channel.
121 : Q5BN36_BOVIN 511 Q5BN36 KCNC1 -- Voltage-gated potassium channe
122 : KCNA6_HUMAN 529 P17658 KCNA6 -- Potassium voltage-gated channe
123 : O70259_MOUSE 532 O70259 Kcna7 -- Voltage-gated potassium channe
124 : Q9VLC6_DROME 717 Q9VLC6 CG4450 -- CG4450-PA.
125 : KCNN2_RAT 580 P70604 Kcnn2 -- Small conductance calcium-acti
126 : Q16322_HUMAN 511 Q16322 KCNA10 -- Cyclic GMP gated potassium cha
127 : KCNN2_HUMAN 579 Q9H2S1 KCNN2 -- Small conductance calcium-acti
128 : Q766U7_BOVIN 584 Q766U7 SK2 -- Small conductance potassium ch
129 : KCNH1_BOVIN 987 O18965 KCNH1 -- Potassium voltage-gated channe
130 : Q8C035_MOUSE 988 Q8C035 Mus musculus adult male olfact
131 : Q8CAD4_MOUSE 649 Q8CAD4 Mus musculus adult male hypoth
132 : KCNAE_DROME 1174 Q02280 eag -- Potassium voltage-gated channe
133 : Q7YW98_MANSE 1011 Q7YW98 Eag K+ channel.
134 : Q98TW2_XENLA 489 Q98TW2 Kv1.10 potassium channel.
135 : Q8I4L3_CAEEL 516 Q8I4L3 F14F11.-- Hypothetical protein F14F11.1e
136 : Q8I4L1_CAEEL 513 Q8I4L1 F14F11.-- Hypothetical protein F14F11.1g
137 : Q26597_SCHMA 512 Q26597 SKv1.1 -- Potassium channel protein.
138 : Q8I4L2_CAEEL 510 Q8I4L2 F14F11.-- Hypothetical protein F14F11.1f
139 : Q9I829_ONCMY 483 Q9I829 Shaker-related potassium chann
140 : O76457_APLCA 514 O76457 Shaw potassium channel Kv3.1a.
141 : Q9PTS9_CHICK 553 Q9PTS9 SK2 -- Small-conductance calcium-acti
142 : Q61RD6_CAEBR 950 Q61RD6 CBG0663-- Hypothetical protein CBG06635.
143 : Q16976_APLCA 577 Q16976 Noninactivating potassium chan
144 : Q9BYS4_HUMAN 456 Q9BYS4 KCNA7 -- Potassium voltage-gated channe
145 : Q9GKU7_MACFA 500 Q9GKU7 Hypothetical protein.
146 : Q60565_MESAU 504 Q60565 Potassium channel Kv8.1.
147 : KCNH4_HUMAN 1017 Q9UQ05 KCNH4 -- Potassium voltage-gated channe
148 : Q8BK61_MOUSE 503 Q8BK61 Kcnv1 -- Mus musculus 10, 11 days embry
149 : Q26041_PANIN 489 Q26041 shaw -- Shaw potassium channel.
150 : KCNH4_RAT 1017 Q9R1T9 Kcnh4 -- Potassium voltage-gated channe
151 : KCNS1_HUMAN 526 Q96KK3 KCNS1 -- Potassium voltage-gated channe
152 : Q86MY5_9TURB 581 Q86MY5 Potassium channel Kv3.1.
153 : Q8BQZ8_MOUSE 491 Q8BQZ8 Kcns3 -- Mus musculus adult male corpor
154 : Q22012_CAEEL 479 Q22012 shw-3 -- Hypothetical protein R186.5.
155 : Q61KS4_CAEBR 531 Q61KS4 CBG0924-- Hypothetical protein CBG09245.
156 : Q86Y85_HUMAN 513 Q86Y85 KCNG1 -- Potassium voltage-gated channe
157 : KCNV2_HUMAN 545 Q8TDN2 KCNV2 -- Potassium voltage-gated channe
158 : Q585L3_HUMAN 494 Q585L3 KCNF1 -- Hypothetical protein KCNF1.
159 : KCNS1_MOUSE 497 O35173 Kcns1 -- Potassium voltage-gated channe
160 : KCNS1_RAT 497 O88758 Kcns1 -- Potassium voltage-gated channe
161 : KCNS2_HUMAN 477 Q9ULS6 KCNS2 -- Potassium voltage-gated channe
162 : Q5KR10_HUMAN 542 Q5KR10 KCNN1 -- Small-conductance calcium-acti
163 : Q5CZY7_MOUSE 538 Q5CZY7 Kcnn1 -- Kcnn1 protein.
164 : Q60U38_CAEBR 793 Q60U38 CBG2019-- Hypothetical protein CBG20190.
165 : KCNN1_RAT 536 P70606 Kcnn1 -- Small conductance calcium-acti
166 : KCNG4_HUMAN 519 Q8TDN1 KCNG4 -- Potassium voltage-gated channe
167 : Q7TSH7_MOUSE 493 Q7TSH7 Kcnf1 -- Potassium voltage-gated channe
168 : Q7JPF0_CAEEL 495 Q7JPF0 kvs-1 -- K (Potassium) voltage-gated se
169 : Q8MRM1_DROME 522 Q8MRM1 SK -- GH16664p.
170 : KCNG2_CHICK 518 O73606 KCNG2 -- Potassium voltage-gated channe
171 : KCNG2_RAT 480 Q9QYU3 Kcng2 -- Potassium voltage-gated channe
172 : Q61JS2_CAEBR 538 Q61JS2 CBG0966-- Hypothetical protein CBG09661.
173 : Q80XM3_MOUSE 506 Q80XM3 Kcng4 -- Voltage-gated potassium channe
174 : Q6YGZ6_CAEEL 477 Q6YGZ6 KVS-2.
175 : Q5SP96_BRARE 494 Q5SP96 OTTDARP--0Novel protein similar to verte
176 : Q7Q445_ANOGA 446 Q7Q445 ORFName--EENSANGP00000021912.
177 : Q86VF9_HUMAN 418 Q86VF9 KCNN3 -- Small conductance calcium-acti
178 : Q60YI6_CAEBR 505 Q60YI6 CBG1822-- Hypothetical protein CBG18227.
179 : KCNQ1_HUMAN 676 P51787 KCNQ1 -- Potassium voltage-gated channe
180 : Q5BN39_COLLI 915 Q5BN39 KCNQ5 -- Potassium voltage-gated channe
181 : Q5VYU2_HUMAN 615 Q5VYU2 KCNQ2 -- OTTHUMP00000031685.
182 : KCNQ1_RAT 669 Q9Z0N7 Kcnq1 -- Potassium voltage-gated channe
183 : KCNQ1_MOUSE 668 P97414 Kcnq1 -- Potassium voltage-gated channe
184 : Q5VYU4_HUMAN 842 Q5VYU4 KCNQ2 -- OTTHUMP00000031684.
185 : KCNQ2_RAT 852 O88943 Kcnq2 -- Potassium voltage-gated channe
186 : KCNG3_HUMAN 436 Q8TAE7 KCNG3 -- Potassium voltage-gated channe
187 : KCNQ2_MOUSE 759 Q9Z347 Kcnq2 -- Potassium voltage-gated channe
188 : KCNG3_MOUSE 433 P59053 Kcng3 -- Potassium voltage-gated channe
189 : Q5UAX1_COLLI 852 Q5UAX1 KCNQ3 -- Voltage-gated potassium channe
190 : Q5VYU5_HUMAN 868 Q5VYU5 KCNQ2 -- OTTHUMP00000031682.
191 : KCNQ2_HUMAN 872 O43526 KCNQ2 -- Potassium voltage-gated channe
192 : KCNQ1_SQUAC 660 O73925 KCNQ1 -- Potassium voltage-gated channe
193 : KCNQ4_HUMAN 695 P56696 KCNQ4 -- Potassium voltage-gated channe
194 : Q967F8_CAEEL 692 Q967F8 kqt-1 -- Potassium channel, kvqlt famil
195 : Q80X11_MOUSE 432 Q80X11 Kcnn2 -- Small conductance calcium-acti
196 : Q60SW1_CAEBR 631 Q60SW1 CBG2073-- Hypothetical protein CBG20733.
197 : Q60W64_CAEBR 421 Q60W64 CBG1924-- Hypothetical protein CBG19249.
198 : Q8QFV0_CHICK 1201 Q8QFV0 SLACK -- Potassium channel subunit.
199 : Q8WMG4_PIG 426 Q8WMG4 KCNN4 -- Intermediate-conductance calci
200 : KCNN4_MOUSE 425 O89109 Kcnn4 -- Intermediate conductance calci
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*** ***
*** Summarized correlation networks ***
*** ***
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1 ( 0) .....................VE..NGG..................................................................G....L.L......L.....................E.....................................................................
10 ( 0) AAAAAAA..A...........VF..LLL..................................................................T....C.C......C.....................F.....................................................................
11 ( 0) PPPPPPP..L...........PF..QVV..................................................................P....I.I......I.....................F.....................................................................
16 ( 0) LLLLLLL..L...........GP..AVV..................................................................P....T.T......T.....................P.....................................................................
19 ( 0) IIIIIII..I...........LP..GII..................................................................V....F.F......F.....................P.....................................................................
21 ( 0) RRRRRRR..R...........GS..NVV..................................................................R....D.D......D.....................S.....................................................................
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2 ( 0) MMMMMMM..M...........NT..EHH..................................................................N....N.N......N.....................T.....................................................................
4 ( 0) VVVVVVV..V...........RL..IEE..................................................................S....F.F......F.....................L.....................................................................
5 ( 0) RRRRRRR..R...........RQ..ADD..................................................................W....D.D......D.....................Q.....................................................................
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3 ( 0) PPPPPPP..P...........DP..ADD..................................................................P....L.L......L.....................P.....................................................................
15 ( 0) FFFFFFF..Y...........SP..PII..................................................................V....S.S......S.....................P.....................................................................
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6 ( 0) RRRRRRR..R...........AF..IVV..................................................................V....S.S......S.....................F.....................................................................
17 ( 0) DDDDDGG..D...........PP..DPP..................................................................G....V.V......V.....................P.....................................................................
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7 ( 0) GGGGGGG..G...........SQ..AEE..................................................................C....L.L......L.....................Q.....................................................................
9 ( 0) VVVVVVV..V...........AG..GGG..................................................................S....F.F......F.....................G.....................................................................
20 ( 0) IIIIIII..I...........SR..DEE..................................................................V....G.G......G.....................R.....................................................................
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200
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455 ( 246) FFFFFFFCCFCCCCCCCCCCCCRCCCRRCCCRCRCCCCRCCCRCCCCCCCCRCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCFFCCCCCCCCRCCCCCCGSGCCCCCCVFCCCCCCCCCCCCCCRCRRFFRFFCCCCCCSRFCCCCFCCFCCCCCCCCCCGRRFRCCCRCCCCCCCRCLMTLLTTCTCATTLMFRLCSRR
540 ( 0) LLLLLLSTTLTTTTTTTTTTTTSTTTSSTTTSTSTTTTSTTTSTTTTTTTTSTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTLLTTTTTTTTSTTTTTTSTSTTTTTTSLTTTTTTTTTTTTTTSTSSLLSLLTTTTTTTSLATTTLTTLTSTTTTTATTTSSLSTATSTTTTTATSISSSSSSSTSTSSSSSSSSTTYY
555 ( 554) WWWWWWWLLWLLLLLLLLLLLLFLLLFFLLLFLFLLLLFLLLFLLLLLLLLFLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLWWLLLLLLLLFLLLVLLQVQLLLLLLQWLLVLLLLLLLLLLLFLFFWWFWWLVVLVLLFWLLLLWLLWLLLLLLILLLLFFWFLLLFLLLLLMLFCIIIIIIIIIIIIIIIIFILLFF
562 ( 561) EEEEEEEFFEFFFFFFFFFFFFTFFFTTFFFTFTFFFFTFFFTFFFFFFFFTFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFEEFFFFFFFFTFFFFFFYFYFFFFFFYEFFFFFFFFFFFFFFTFTTEETDDFFFFFFFTEFFFFEFFEFFFFFFFFFFFTTETFFFTFFFFFFFTFFFLFFLLFLFLLLFFFTFLGNN
610 ( 0) LLLLLLLMMLMMMMMMMMMMMMFMMMFFMMMFMFMMMMFMMMFMMMMMMMMFMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMLLMMMMMMLMFLMMIMMIIIMMMMMMILMMIMMMMMMMMMMMFMFFLLFMMMIIMIMMFMMMMMLMMLMMMMMMIMMMMFFIFMMMFMMMMMMMFMVLLVVLLMLMLLLVLLFMMFFF
647 ( 661) VVVVVVVIIVIIIIIIIIIIIIVIIIVVIIIVIVIIIIVIIIVIIIIIIIIVIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIVVIIIIIIIIVIIIIIILILIIIIIILVIIIIIIIIIIIIIIVIVVVVVVVIIIIIIIVMIIIIVIIVIVIIIILIIIIVVVVIIIVIIIIIIIVILLLLLLLILILLLLLLVLILVV
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200
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462 ( 253) AAAAAQQEEHEEEEEEEEEEEEREEERREEEREREEEEREEEREEEEEEEEREEEEEEEEEEEEEEEEEEEEEEEEEEEEEETTEEEEEEEEREEEEEEIEIEEEEEENSEEEEEEEEEEEEEERERRPPRPPEEEEEEERPEEEEQEEQEEEEEEEEEEERREREEEREEEEEEEREEEEEEEEEEEEEEEEEREELQQ
466 ( 257) VVVVVVVRRVRRRRRRRRRRRRIRRRIIRRRIRIRRRRIRRRIRRRRRRRRIRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRVVRRRRRRRRIRRRRRRRRRRRRRRRNVRRRRRRRRRRRRHRIRIIVVIVVRRRRRRRIVRRRRVRRVRRRRRRRRRRRIIVIRRRIRRRRRRRIKRRRRRRRRRRRRRRRRIRRLII
643 ( 657) IIIIIIIPPIPPPPPPPPPPPPVPPPLLPPPVPVPPPPVPPPVPPPPPPPPVPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPIIPPPPPPPPVPPPPPPLPLPPPPPPLIPPPPPPPPPPPPPPVPVVIIVIIPPPPPPPVITPPPVPPVPTPPPPPPPPPVVVVPPPLPPPPPPPVPPPPPPPPPPPPPPPPPVPPVLL
651 ( 0) IIIIIIIFFIFFFFFFFFFFFFLFFFLLFFFLFLFFFFLFFFLFFFFFFFFLFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFIIFFFFFFFFLFFFFFFTFTFFFFFFTIFFFFFFFFFFFFFFLFLLFFLIIFFFFFFFLIFFFFIFFIFFFFFFFFFFFLLILFFFLFFFFFFFLFFFFFFFFFFFLFFFFFLFFFLL
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200
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551 ( 550) LLLLLLLLLLLLLLLLLLLLLLFLLLFFLLLFLFLLLLFLLLFLLLLLLLLFLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLFLLLLLLMLMLLLLLLMLLLLLLLLLLLLLLLFLFFMLFLLLLLLLLLFLLLLLMLLMLMLLMLLLLLLFFLFLLMFLLLLMLLFDTTTTTTTLTLTTTTTTFTSLFF
655 ( 0) YYYYYYYYYYYYYYYYYYYYYYKYYYRRYYYKYKYYYYKYYYKYYYYYYYYKYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYKYYYYYYPYPYYYYYYPYYYYYYYYYYYYYYYKYKKYYKTTYYYYYYYKTYYYYYYYYYYYYAYYYYYYKKYKYYSRYYQYSYYKAVVVVVVVYVYVVVVVVKVTVKK
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200
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629 ( 643) SSSSSSSGGSGGGGGGGGGGGGCGGGATGGGCGCGGGGCGGGCGGGGGGGGCGGGGGGGGGGGGGGGGGGGGGGGFGGGGGGSSGGGGGGGGCGGGGGGKGKGGGGGGKTGGGGGGGGGGGGGGCGCCASCTTGGGGGGGCGGGAASAGSAGAGAAAAAAACCTCAAATAAAAAAGCAASAAAAAGAGAAAAAACAAPCC
645 ( 659) GGGGGGGPPGPPPPPPPPPPPPAPPPAAPPPAPAPPPPAPPPAPPPPPPPPAPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPGGPPPPPPPPAPPPPPPQPQPPPPPPQGPPPPPPPPPPPPPPAPAAGGAGGPPPPPPPAGPPAAGAPGTPTPTTSHTTTAAGATHTATTSTTHPATGGGGGGGTGTGGGGGGAGSLAA
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200
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644 ( 658) FFFFFFFVVFVVVVVVVVVVVIVVVIVVVVIVVVVVVVVVVVVIIVVIIVVVVVVVVVVIIIVVIVVVVVVIVVVDVVVVVVFFVVVVVVVVVVVVVVVYVYVVVVVVYFVVVVVVVVVVVVVVVVVVFFVFFVVVVVVVVFIVIIFIVFIVIVIVIIIIIVVFVAIIVVVIAIIVVIAAAAAAAIAIAAAAAAVAIVVV
646 ( 660) NNNNNNNVVNVVVVVVVVVVVIVVVIVVVVIVVVVVVVVVVVVIIVVIIVVVVVVVVVVIIIVVIVVVVVVIVVVVVVVVVVNNVVVVVVVVVVVVVVVKVKVVVVVVKNVVVVVVVVVVVVVVVVVVNNVHHVVVVVVVVHVVIINIVNIIIVISIPIILVVNVSPIVSSMSIPVVIIIIIIIIFIFIIIIIIVIMPVV
