KChannelDB Two-pore channels (K2p) - Mutation data

The logo  2005, KChannelDB.

This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.



                                            140       150                                                                                                                                               
                                         ====|=========|===                                                                                                                                             
CONSENSUS          TVQASAGESCVRIGVMKRQNARFLLLILAYLLYLLIGAAVFSALEQPHEASLRQELVAEKRRFLREHPCLSEEELEELLQ                                                                                                     
KCNK2_MOUSE        TVLASRVESDSAINVMKWK..TVSTIFLVVVLYLIIGAAVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQ
Q6P6P9_MOUSE       TVLASRVESDSAINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQ
Q8HY88_BOVIN       TVLASRVESDTTINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHACVNSTELDELIQ
Q5DP48_HUMAN       TVLASRVESDTTINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQ
Q9NRT2_HUMAN       TVLASRVESDTTINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQ
Q920B6_RAT         TVLASRVESDSAINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQ
Q5DNW5_RAT         TVLASRVESDSAINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQ
KCNK2_HUMAN        TVLASRVESDTTINVMKWK..TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQ
Q6Q834_RABIT       TVVARMEGTSQGGLQSVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQ
KCNKA_HUMAN        TVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQ
Q6B014_HUMAN       TVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQ
KCNKA_RAT          TVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQ  !  
Q8BUW1_MOUSE       TVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQ
Q9Z2T2_RAT         MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLG
KCNK1_HUMAN        MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLG
Q99L99_MOUSE       MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLG
Q5RD07_PONPY       MLQSLAGSSCVRLVERHRSARCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLG
KCNK1_MOUSE        MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSEELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLG
Q8R454_CAVPO       MLQSLAGSSCVRLVERHRSAWCFGLLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLG
Q5UE96_RABIT       MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFVEEHECLSEQQLEQFLG
Q8AVI5_XENLA       MLQALATNPCVRLIEQNQTCWFFSFLMLGYLLYLLIGAAIFSAVELPHEHLLREELLDLKHRYLQENECLTEERLEKFLS
Q5HZV4_XENTR       MLQALATNPCLRLIQRNQTCWCFVLLMLGYLLFLLIGAAIFSAVELPHEHVLREELLDLKHRYLQENECLSEERLESFLS
KCNK3_RAT          ...............MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRL.ELRQLELRARYNLSEGGYEELER  !  
KCNK3_MOUSE        ...............MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRL.ELRQLELRARYNLSEGGYEELER  !  
KCNK9_HUMAN        ...............MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEdqLE.LVI  !  
KCNK3_HUMAN        ...............MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRL.ELRQQELRARYNLSQGGYEELER
Q63ZI0_XENLA       ...............MKRQNVRTLSLIICTFTYLLVGAAVFDALESDYEMREEEKLKAEEIRLKGKYNISSEdqLE.LVI
KCNK4_MOUSE        .................MRSTTLLALLALVLLYLVSGALVFQALEQPHEQQAQKKMDHGRDQFLRDHPCVSQKSLEDFIK
KCNK9_CAVPO        ...............MKKQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIRGKYNISTEdqLE.LVI
Q924I4_RAT         .................MRSTTLLALLALVLLYLVSGALVFYALEQPHEQQVQKDLEDGRDQFLKDHPCVSQKNLEGFIK
KCNKC_HUMAN        LPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAH.GVAEPELRAFLR
Q76M80_MOUSE       LPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAH.GVAEPELRAFLR
KCNKC_RAT          LPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAH.GVAEPELRAFLR
KCNK4_HUMAN        .................MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIK
Q923V6_RAT         ...............MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDdqLE.LVI
Q5TZ59_BRARE       ...............MKRQNIRTLVLIICTFTYLLVGAAVFDALESKMEITQKKILDDRK.RELMDKYNLSKVNFDELER
KCNKD_RAT          ...MAGRGCSCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGH.NLSREELRGFLR
KCNKD_MOUSE        ...MAGRGCGCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGH.NLSREELRGFLR
Q9JLD4_RAT         ...............MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDdqLE.LVI
KCNKD_HUMAN        ...MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGH.NLSRDELRGFLR
KCNKF_HUMAN        ...............MRRPSVRAAGLVLCTLCYLLVGAAVFDALESEAE.SGRQRLLVQKRGALRRKFGFSAEDYRELER
Q9ESM5_RAT         ...............MKRQNVRTLALIVCTFTYLLESELR..QLE..................LRARYNLSEGGYEELER
KCNKF_RAT          ...............MRKQSARTAALILCILSYLLVGAAVFDALESEAE.RSRQRLLARKRGEFRRKYRFSADDYRELER
Q5UE95_RABIT       ..................MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILQ
Q9JK62_MOUSE       ..................MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLSQEGLDKILQ
KCNK5_HUMAN        ..................MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILE
Q9JJ14_MOUSE       .............MGSLKPWARYLLLLMAHLLAMGLGAVVLQALEGPPARHLQAQVQAELASFQAEhaCLPPEALEELLG
Q60VG3_CAEBR       ...............MKRQNIRTLSLIVCTLTYLLVGAAVFDALETENEILQR.KLVARVREKLKTKYNMSNADYEILE.
KCNKG_HUMAN        .........MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQ
Q9ERU5_RAT         ................MRRGALLASALVAYAGYLALGALLVARLERPHEARLRAELGTLREQLLRHSPCVAAHALDAFVE
SUP9_CAEEL         ...............MKRQNIRTLSLIVCTLTYLLVGAAVFDALETENEILQR.KLVQRVREKLKTKYNMSNADYEILE.
KCNK6_HUMAN        ................MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVE  !  
Q5VSE6_BRARE       .MACRSGCCCNSIGSFNEDNARFLMLALLIIIYLLCGAAVFSALEQPKEKLAKERWAQRIEQFTNKY.NLSQDDLKNFLR
Q8I6M6_APLCA       MMSRPGRRGCCRIIHLKEDNARFLLLAIVMVFYMLSGAALFTALERDNEVEEKRIYDEIVKNFKEKYTMVNESDLQYLLD
Q5HZL7_XENLA       ..................MVDRGPILTSAVIFYLSIGAAIFQVLEEPNWKAATQLYKENKGKILAKHSCLSPRDLEEILE
Q8R453_CAVPO       ................MRRGALLAIALVAYAAYLALGALLVAWLERPHEARLRAELGSLREQLLRRSPCVEPPVLDAFVE
KCNK7_HUMAN        .............MGGLRPWSRYGLLVVAHLLALGLGAVVFQALEGPPACRLQAELRAELAAFQAEhaCLPPGALEELLG
Q6X6Z4_HUMAN       .........MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQ
KCNK8_MOUSE        .............MGSLKPWARYLLLLMAHLLAMGLGAVVLQALEGPPARHLQAQVQAELASFQAEhaCLPPEALEELLG
Q6X6Z5_HUMAN       .........MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQSEKLRFLENYTCLDQWAMEQFVQ
Q8QZZ6_CAVPO       .............MWFLRPWTRYMLLVMAHVLAMGLGAVVLQALEGPPALRHQAELKAALAAFQAEfaCLPQGALEELLG
Q801T4_XENLA       ................MKFWLLLTLLVCVYVIYLLLGALVISVIESPYEASLRDELRQLKNVFLNESPCVNVSSLEAFLE
Q8HZT2_BOVIN       SGWRAWNASERGVQGCAVPVPSTLLLLLTYLTYLVLGTCVFWALESPAAHDSSKRFQRDKWALLRNFTCLDGQALDSLIR  !  
KCNKH_HUMAN        .MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIR
Q9VFS9_DROME       ...............MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDF......
Q6X6Z3_HUMAN       .........MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQ

                                                                              250       260                                                                                                             
                                                                      =========|=========|=                                                                                                             
CONSENSUS          RVLEASNAGVSPLGNSSNNSNWDFGSAFFFAGTVITTIGYGHTAPLTDGGKAFCIFYALLGIPLTLLLLAALGERLITGV                                                                                                     
KCNK2_MOUSE        QIVAAINAGIIPLGNSSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q6P6P9_MOUSE       QIVAAINAGIIPLGNSSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q8HY88_BOVIN       QIVAAINAGIIPLGNTSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q5DP48_HUMAN       QIVAAINAGIIPLGNTSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q9NRT2_HUMAN       QIVAAINAGIIPLGNTSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q920B6_RAT         QIVTAINAGIIPLGNNSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q5DNW5_RAT         QIVTAINAGIIPLGNNSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
KCNK2_HUMAN        QIVAAINAGIIPLGNTSNqsHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQliFGK
Q6Q834_RABIT       HALDADNAGVSPIGNSSNnsHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQliFGK
KCNKA_HUMAN        HALDADNAGVSPIGNSSNnsHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQliFGK
Q6B014_HUMAN       HALDADNAGVSPIGNSSNnsHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQliFGK
KCNKA_RAT          HALDADNAGVSPVGNSSNSshWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQliFGK
Q8BUW1_MOUSE       HALDADNAGVSPVGNSSNSshWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQliFGK
Q9Z2T2_RAT         RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHV
KCNK1_HUMAN        RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHV
Q99L99_MOUSE       RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHV
Q5RD07_PONPY       RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHV
KCNK1_MOUSE        RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTALVQRVTVHV
Q8R454_CAVPO       RVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHV
Q5UE96_RABIT       RVLEANNYGVSVRSNASGNWNWDFASALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHV
Q8AVI5_XENLA       RVLEASNYGVSMLNNVSGNPNWDFTSALFFVSTVLSTTGYGHTVPLSNGGKSFCIIYSIIGIPLTLLLFTALVQRIMVYV
Q5HZV4_XENTR       RVLEASNYGVSMLNNVSGNPNWDFTSALFFVSTVLSTTGYGHTVPLSNAGKTFCIIYSIIGIPLTLLLFTALVQRIMVHV
KCNK3_RAT          VVLR........LKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFV
KCNK3_MOUSE        VVLR........LKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFV  !  
KCNK9_HUMAN        LQSEPHRAGV..........QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFV  !  
KCNK3_HUMAN        VVLR........LKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLV  !  
Q63ZI0_XENLA       MQSEPHRAGV..........QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFV
KCNK4_MOUSE        LLVEALGGGANPETSWTNSSnwNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSL
KCNK9_CAVPO        LQSEPHRAGV..........QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFV
Q924I4_RAT         LVAEALGGGANPETSWTNSSnwNLGSAFFFSGTIITTIGYGNIALHTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSL
KCNKC_HUMAN        HYEAALAAGV...RADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERieRQL
Q76M80_MOUSE       HYEAALAAGV...RADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERieRQL
KCNKC_RAT          HYEAALAAGV...RADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERieRQL
KCNK4_HUMAN        EVADALGGGADPETNSTSNSswDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSl
Q923V6_RAT         LQSEPHRAGV..........QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFV  !  
Q5TZ59_BRARE       VVLQ........LKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFV
KCNKD_RAT          HYEEATKAGI...RMDSVRPRWDFTGAFYFVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITvv
KCNKD_MOUSE        HYEEATRAGI...RMDSVRPRWDFTGAFYFVGTVVSTIGFGMTTPATTGGKIFLIFYGLIGCASTILFFNLFLERLITvv
Q9JLD4_RAT         LQSEPHRAGV..........QWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFV
KCNKD_HUMAN        HYEEATRAGIRV...DNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITII
KCNKF_HUMAN        LALQAE........PHRAGRQWKFPGSFYFAITVITTIGYGHAAPGTDSGKVFCMFYALLGIPLTLVTFQSLGERLNAVV
Q9ESM5_RAT         VVLR........LKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFV
KCNKF_RAT          LALQAE........PHRAGRQWRFAGSFYFAITVITTIGYGHAAPGTDSGKVFCMFYALLGIPLTLVTFQSLGERLNALV
Q5UE95_RABIT       VVSDASGQGVAITGNQTFN.NWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRA
Q9JK62_MOUSE       VVSDAADQGVAITGNQTFN.NWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRA
KCNK5_HUMAN        VVSDAAGQGVAITGNQTFN.NWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRA  !  
Q9JJ14_MOUSE       AVLRAQAHGVSSLGNSSETSNWDLPSALLFTASILTTTGYGHMAPLSSGGKAFCVVYAALGLPASLALVAALRHCL.LPV
Q60VG3_CAEBR       .......ATIVKSVPHKAGYQWKFSGAFYFATTVITTIGYGHSTPMTDAGKVFCMLYALAGIPLGLIMFQSIGERMNTF.
KCNKG_HUMAN        VIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHL
Q9ERU5_RAT         RVLAAGRLGRAVLANASGPAnwDFASALFFASTLVTTMGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLL
SUP9_CAEEL         .......ATIVKSVPHKAGYQWKFSGAFYFATTVITTIGYGHSTPMTDAGKVFCMLYALAGIPLGLIMFQSIGERMNTF.
KCNK6_HUMAN        RVLAAGRLGRVVLANASGSAnwDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLL  !  
Q5VSE6_BRARE       NYEEANVAGIRV...DATRARWDFAGAFYFVGTVVSTIGFGMTTPVTIAGKIFLIFYGLIGCAATILFFNLFLEriAFVL
Q8I6M6_APLCA       KHSEAETAGIV....GNRRPRWDFSGAFYFVGTVVSTIGFGMTTPRTPAGKVVLIFYGFFGCAGAILFFNLFLERIITFL
Q5HZL7_XENLA       TVSNAAGQGVTITGNTTFN.NWNWPNAVIFAATVITTIGYGNIAPKTPAGRLFCIFYGLFGVPLCLTWISALGKFFGGRA
Q8R453_CAVPO       RVLAAGRLARSVLANASGATnwDFASALFFASTLVTTVGYGYTTPLTDAGKGFSIAFALLGVPTTMLLLTATAQHL.ALL
KCNK7_HUMAN        TALATQAHGVSTLGNSSEGRTWDLPSALLFAASILTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCL.LPV
Q6X6Z4_HUMAN       VIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRVHL
KCNK8_MOUSE        AVLRAQAHGVSSLGNSSETSNWDLPSALLFTASILTTTGYGHMAPLSSGGKAFCVVYAALGLPASLALVAALRHCL.LPV
Q6X6Z5_HUMAN       VIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHL
Q8QZZ6_CAVPO       TALRTQAHGVSGLGNHSETSNWDLPSALLFTVSLLTTTGYGHMAPLSTGGKVFCMVYAALGVPASLALVAVLRHCL.LPV
Q801T4_XENLA       KIINANKYGVSVLHNASNDSKWDIASSLFFASTLVTTVGYGYTTPLTDSGKAFCIFYGLIGVPFTMLVLSSFVQRLMVMF
Q8HZT2_BOVIN       GIIEAYKNGDIVLGNTTSMGRWEFVGSFFFSVSTITTIGYGNLSPRTMAARLFCIFFALVGIPLNLVVLNRLGHCMQQGV
KCNKH_HUMAN        DVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGV
Q9VFS9_DROME       ...KVMETVVLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIGERAVRSS
Q6X6Z3_HUMAN       VIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHL

                                               340       350                                                                                                                                            
                                          ======|=========|===                                                                                                                                          
CONSENSUS          TRAPLERFFIRWGVSQTKVRIVSTVLFGLFGCLVFLAIPAAVFSHIEEGWSFLEAFYFCFITLSTIGFGDYVAGQGAGQL                                                                                                     
KCNK2_MOUSE        GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q6P6P9_MOUSE       GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q8HY88_BOVIN       GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q5DP48_HUMAN       GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q9NRT2_HUMAN       GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q920B6_RAT         GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q5DNW5_RAT         GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
KCNK2_HUMAN        GIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIE.GWSALDAIYFVVITLTTIGFGDYVAG.GSDIE
Q6Q834_RABIT       SIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIE.GWTALESIYFVVVTLTTVGFGDFVAGGNAGIN
KCNKA_HUMAN        SIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIE.GWTALESIYFVVVTLTTVGFGDFVAGGNAGIN
Q6B014_HUMAN       SIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIE.GWTALESIYFVVVTLTTVGFGDFVAGGNAGIN
KCNKA_RAT          SIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIE.GWTALESIYFVVVTLTTVGFGDFVAGGNAGIN
Q8BUW1_MOUSE       SIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIE.GWTALESIYFVVVTLTTVGFGDFVAGGNAGIN
Q9Z2T2_RAT         TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
KCNK1_HUMAN        TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
Q99L99_MOUSE       TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
Q5RD07_PONPY       TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
KCNK1_MOUSE        TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
Q8R454_CAVPO       TRRPVLYFHIRWGFSKQMVGIVHAVVLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
Q5UE96_RABIT       TRRPVLYFHVRWGFSKQVVAIVHAVLLGLITVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
Q8AVI5_XENLA       THRPISYFHLRWGYNKQTVAIVHALIIGFVAILCFFLIPAAVFSALEEDWNFLESFYFCFISLSTIGLGDYVPAEGQNQR
Q5HZV4_XENTR       THRPISYFHLRWGYNKQTVAVVHALVIGFVAILCFFLIPAAIFSALEDDWNFLESFYFCFISLSTIGLGDYVPAEGQNQR
KCNK3_RAT          .RYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYE.RWTFFQAYYYCFITLTTIGFGDYVALQKDQAL
KCNK3_MOUSE        .RYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYE.RWTFFQAYYYCFITLTTIGFGDYVALQKDQAL
KCNK9_HUMAN        .RYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEE.WSFFHAYYYCFITLTTIGFGDYVALQTKGAL
KCNK3_HUMAN        .RYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYE.HWTFFQAYYYCFITLTTIGFGDYVALQKDQAL
Q63ZI0_XENLA       K.YLLKRIKKCCGMHSTDVSMENMVTVGFFSCMGTLCIGAAAFSHYEE.WSFFQAYYYCFITLTTIGFGDYVALQKNRAL
KCNK4_MOUSE        RRGIgeAIFLKWHVPPGLVRSLSAVLFLLIGCLLFVLTPTFVFSYME.SWSKLEAIYFVIVTLTTVGFGDYVPGDGTGQ.
KCNK9_CAVPO        .RYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCIGAAAFSQCEE.WSFFHAYYYCFITLTTIGFGDYVALQSKGAL
Q924I4_RAT         RRGIgeAVFLKWHVPPGLVRMLSAVLFLLIGCLLFVLTPTFVFSY.MKSWSKLKAIYFVIVTLTTVGFGDYVPGDGTGQ.
KCNKC_HUMAN        RRSGLLPATFRRGSALSEAdsVYHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYR
Q76M80_MOUSE       RRSGLLPATFRRGSALSEAdsVYHVLLILGLFAVLLACCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYR
KCNKC_RAT          RRSGLLPATFRRGSALSEAdsVYHVLLILGLFAVLLACCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYR
KCNK4_HUMAN        gIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYME.DWSKLEAIYFVIVTLTTVGFGDYVAGADPRQ.
Q923V6_RAT         .RYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCE.DWSFFHAYYYCFITLTTIGFGDFVALQSKGAL  !  
Q5TZ59_BRARE       K.YLLHRLKKCLGLRHTEVSMANMVCIGLISCMSTLCVGAAAFSRYE.DWSFFHAYYYCFITLTTIGFGDYVALQKDNAL
KCNKD_RAT          MRTCHHQQLRRRGTVARDNrsVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVASSTIGFGDLVSSQNAQYE
KCNKD_MOUSE        MRSCHQQQLRRRGAVTQdkPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYE
Q9JLD4_RAT         .RYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGLVPWAAAFS.QCE.DWSFFHAYYYCFITLTTIGFGDFVALQSKGAL
KCNKD_HUMAN        AYicHQRQLRRRGALPQekPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYE
KCNKF_HUMAN        .RRLLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSHFE.GWTFFHAYYYCFITLTTIGFGDFVALQSGEAL
Q9ESM5_RAT         .RYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYE.RWTFFQAYYYCFITLTTIGFGDYVALQKDQAL
KCNKF_RAT          .RCLLLAAKRCLGLRRPHVSAENMVVAGLLLCAATLALGAAAFAHFE.GWTFFHAYYYCFITLTTIGFGDFVALQRDEAL
Q5UE95_RABIT       KR..LGQFLTRRGVSLRKAQITCTAIFIVWGVLVHLVIPPFVFMVTEE.WDYIEGFYYSFITISTIGFGDFVAGVNPSAN
Q9JK62_MOUSE       KR..LGQFLTRRGVSLRKAQITCTAIFIVWGVLVHLVIPPFVFMVTEE.WNYIEGLYYSFITISTIGFGDFVAGVNPSAN
KCNK5_HUMAN        KR..LGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTE.GWNYIEGLYYSFITISTIGFGDFVAGVNPSAN  !  
Q9JJ14_MOUSE       FSRPGDWVAIRWQLAPAQAALLQAAGLGLLVACVFMLLPALVLWGVQGDCSLLEAIYFCFGSLSTIGLGDLLpgRGLHPA
Q60VG3_CAEBR       .AAKLLRFIRKAAGKPAVVTSSDLIVFCTGWGGLLIFGGAFMFSSYE.NWTYFDAVYYCFVTLTTIGFGDYVALQKRGSL
KCNKG_HUMAN        AAIERWEDRPRRSQVLQVLG...LALFLTLGTLVILIFPPMVFSHVE.GWSFSEGFYFAFITLSTIGFGDYVVGTDPSKH
Q9ERU5_RAT         THAPLSWLSLRWGWHPQRAARWHLVALLMVIVAIFFLIPAAVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQP
SUP9_CAEEL         .AAKLLRFIRRAAGKQPIVTSSDLIIFCTGWGGLLIFGGAFMFSSYE.NWTYFDAVYYCFVTLTTIGFGDYVALQKRGSL
KCNK6_HUMAN        THVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQP
Q5VSE6_BRARE       KFCHERRESRKAGPTQNCRrsVYCVMLILGVAAILVSCCASAMYSAAEGWDYLDALYFCFVAFSTIGFGDMVSNQREIYE
Q8I6M6_APLCA       arAIHERGQRKKGLMGRRRssVYWVMLILLLGATVVAVIASGMYHPVEDWTYWEAMYFCFVAFSTIGFGDYVVSQQAEYP
Q5HZL7_XENLA       KR..LGQFLTKRGVTLRKAQITCTAIFILWGVLVHLVIPPFIFMKTE.GWDYIEGLYFSFITITTIGFGDYVAGVNPNVN
Q8R453_CAVPO       THTPLSWLSFHWGWDPRRAARWHLAALLAVVMTTCFLVPAMVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQP
KCNK7_HUMAN        LSRPRAWVAVHWQLSPARAALLQAVALGLLVASSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDLLPGRglHPV
Q6X6Z4_HUMAN       AAIERWEDRPRRSQVLQVLG...LALFLTLGTLVILIFPPMVFSHVE.GWSFSEGFYLLSITLSTIGFGDYVVGHPLniT
KCNK8_MOUSE        FSRPGDWVAIRWQLAPAQAALLQAAGLGLLVACVFMLLPALVLWGVQGDCSLLEAIYFCFGSLSTIGLGDLLpgRGLHPA
Q6X6Z5_HUMAN       AAIERWEDRPRRSQVLQVLG...LALFLTLGTLVILIFPPMVFSHVE.GWSFGEGFYFAFITLSTIGFGDYVVGTDPSKH
Q8QZZ6_CAVPO       LSCPGAWVASRWQLAPTRA.LLQAAGLGLLVAGIFVLLPALVLWGLQGDRTLLEAIYFCFGSLSTIGLGDLLpgQSLHPG  !  
Q801T4_XENLA       THKPIRYLQVHRGFDRKMVTQLHFIFLLLLVFVFFLIIPSAIFNTIETSWSFLDAFYFCFISLCTIGLGDYVPGEQNDQW
Q8HZT2_BOVIN       HRCARRLGGAWK..DPAKARWLAGSSALLSGLLLFLLLPPLLFNHME.GWTYVEGFYFSFVTLSTVGFGDYVIGMNPSRN
KCNKH_HUMAN        NHWASRLGGTW..QDPDKARWLAGSGALLSGLLLFLLLPPLLFSHME.GWSYTEGFYFAFITLSTVGFGDYVIGMNPSQR
Q9VFS9_DROME       LRCKR...........TVASEVDLICVVTTLSSLTIAGGAAAFSKFE.GWSYFDSVYYCFITLTTIGFGDMVALQRDNAL
Q6X6Z3_HUMAN       AAIERWEDRPRRSQVLQVLG...LALFLTLGTLVILIFPPMVFSHVE.GWSFSEGFYFAFITLSTIGFGDYVVG....LR

                                 450       460                                                                                                                                                          
                          ========|=========|=                                                                                                                                                          
CONSENSUS          YRPLYKPFVFFYILLGLAVIAAVLNTIVMNLEVRKKDTKEEVGEFKAHAAEWIANVTAEFGSSRRRLSVEIKDKQQRAES                                                                                                     
KCNK2_MOUSE        YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS  !  
Q6P6P9_MOUSE       YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
Q8HY88_BOVIN       YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
Q5DP48_HUMAN       YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
Q9NRT2_HUMAN       YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS  !  
Q920B6_RAT         YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS  !  
Q5DNW5_RAT         YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
KCNK2_HUMAN        YLDFYKPVVWFWILVGLAYFAAVLSMIGRLVRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
Q6Q834_RABIT       YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAAT
KCNKA_HUMAN        YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAAT  !  
Q6B014_HUMAN       YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAAT
KCNKA_RAT          YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAAT
Q8BUW1_MOUSE       YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAAT
Q9Z2T2_RAT         FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIMEHDQLSFSSITEQAAGLKEEQKQNEP
KCNK1_HUMAN        FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEP
Q99L99_MOUSE       FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDLVHIMEHDQLSFSSVTEQVAGLKEEQKQSEP
Q5RD07_PONPY       FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEP
KCNK1_MOUSE        FRELYKIGITCYLLLGLITMLVVLETFCELHELKKFRKMFYVKKDKDEDLVHIMEHDQLSFSSVTEQVAGLKEEQKQSEP
Q8R454_CAVPO       FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIVEHDQLSFSSITDQAASVKEEQKQSEP
Q5UE96_RABIT       FRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITEQAAGMKEDQKQNEP
Q8AVI5_XENLA       YRQLYKFGITCYLILGLIVMLVVLETFCELQGLKKFRKIFFRKKVKEGDQINIIEHDQLTLASISDQAASLKEDQILNEL
Q5HZV4_XENTR       YRQLYKFGITCYLILGLIVMLVVLETFCELQGLKKFRKMFYRKKMKEGDQLNIIEHDQLTLASISEQAASLKEEQMLDEH
KCNK3_RAT          qqPQYVAFSFVYILTGLTVIGAFLNLVvmNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAG
KCNK3_MOUSE        qqPQYVAFSFVYILTGLTVIGAFLNLVvmNAEDEKRDAEHRALLTHNGQAVGLGGLSCLSGSLGDGVRPRDPVTCAAAAG
KCNK9_HUMAN        QKklYVAFSFMYILVGLTVIGAFLNLVvmNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
KCNK3_HUMAN        qqPQYVAFSFVYILTGLTVIGAFLNLVvmNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
Q63ZI0_XENLA       QKklYVAFSFMYILVGLTVIGAFLNLVvmNSEDERRDAEERASLAGNRNSMIIHIQEDTPHGRQRYKAEVTDLQSVCSCM
KCNK4_MOUSE        NSPAYQPLVWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPS
KCNK9_CAVPO        QrpFYVAFSFMYILVGLTVIGAFLNLVvmNSDEERGEGEEGAALPGNPSSVVTHISEEARQVRQRYRGEGGDLQSVCSCA
Q924I4_RAT         NSPAYQPLVWFWILFGLAYFASVFTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPS
KCNKC_HUMAN        NQGLYRLGNFLFILLGVCCIYSLFNVIslNWMLRKLSCRCCARCCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDS
Q76M80_MOUSE       NQGLYRLGNFLFILLGVCCIYSLFNVIslNWMLRKLSCRCCTRCCPAPGAPLARRNAITPGSRLRRRLAALGADPATRDS
KCNKC_RAT          NQGLYRLGNFLFILLGVCCIYSLFNVIslNWMLRKLSCRCCTRCCPAPGAPLSRRNAITPGSRLRRRLAALGTDPAARDS
KCNK4_HUMAN        DSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPP
Q923V6_RAT         QrpFYVAFSFMYILVGLTVIGAFLNLVvmNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCF
Q5TZ59_BRARE       qnPQYVAFSFMYILTGLTVIGAFLNLVvmNAEDERRDAEQRTLLSRNRQSGGAGTNHCISDPPSSSTAGHGGGSGKGLCN
KCNKD_RAT          NEGLYRFVNFFFILMGVCCIYSMFNVIsvNWILRKLDSGCFPQCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTD
KCNKD_MOUSE        SQGLYRFFNFFLILMGVCCIYSLFNVIsvNWILRKLDSGCFPPCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTD
Q9JLD4_RAT         QrpFYVAFSFMYILVGLTVIGAFLNLVvmNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCF
KCNKD_HUMAN        SQGLYRFANFVFILMGVCCIYSLFNVIslNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAESDTD
KCNKF_HUMAN        QRKlyVAFSFLYILLGLTVIGAFLNLVVLRFLVASADWPERAARPPSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHK
Q9ESM5_RAT         qqPQYVAFSFVYILTGLTVIGAFLNLVvmNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAG
KCNKF_RAT          QKKPpvAFSFLYILLGLTVIGAFLNLVVLRFLASAEAPERAALRRASVFRRGAPESRVRIPYPFHPLETWARDNPAFSPP
Q5UE95_RABIT       YHALYRYFVELWIYLGLAWLSLFVNWKvmFVEVHKAIKKRRRRRKESFDSSPRSRQALQVAGSTASKDVNIFSFLSKKEE
Q9JK62_MOUSE       YHALYRYFVELWIYLGLAWLSLFVNWKvmFVEVHKAIKKRRRRRKESFESSPHSRKALQMAGSTASKDVNIFSFLSKKEE
KCNK5_HUMAN        YHALYRYFVELWIYLGLAWLSLFVNWKvmFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEE  !  
Q9JJ14_MOUSE       IYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGPSGSRTDEDQDGILGQDELALSTVLPDAPVLGPTTPASV
Q60VG3_CAEBR       qqPEYVFFSLVFILFGLTVISAAMNLLvmNTEDERRDEQEAILAAQGLVRVGDPSCDDDFGRLPLSDNVSLASCSCYQLP
KCNKG_HUMAN        YISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGL
Q9ERU5_RAT         YRSLYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDPARLHQDEDDQVDILDARTDLHQHLSAASHANYA
SUP9_CAEEL         qqPEYVFFSLVFILFGLTVISAAMNLLvmNTEDERRDEQEAILAAQGLVRVGDPTADDDFGRLPLSDNVSLASCSCYQLP
KCNK6_HUMAN        YRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYA
Q5VSE6_BRARE       AQVAYRVGNFLFILTGVCCIYSLFNVIslNWLLRRLETPCHCPGRGNRHPRRNAVVPGHMRSRRENSIETDAVNDSEADG
Q8I6M6_APLCA       NVVLYRLGNFIFIVLGCCCIYSLFNVTslNWMLRKLNCECRIRKPPMTRRNAITPGHLQRGGTMSTAGAAPAGSATGGGA
Q5HZL7_XENLA       YNVLYRYFVEIWIYLGLAWLSLFFNWKVSMFLEVHKAIKKRRKRRKESFESDPQIKQTKAMPMTNPKDVNIFSFLSKKEE
Q8R453_CAVPO       YRALYKVLVTVYLFLGLIAMMLVLQTFRHVSDLHGLTELILLPRPCPASLQEEEDDQVEIPDPQLDLHQRLSASSHNDYA
KCNK7_HUMAN        IYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSGPVTAEDQGGILGQDELALSTLPPAAPASGQAPAC..
Q6X6Z4_HUMAN       PSGLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHSPGLAFPLPDCNIPDQERFRPLHPGAWKFWPLPLPSSN
KCNK8_MOUSE        IYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGPSGSRTDEDQDGILGQDELALSTVLPDAPVLGPTTPA..
Q6X6Z5_HUMAN       YISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSRGLGVKDGAASDPSGLPRPQKIPISA.............
Q8QZZ6_CAVPO       DYQLGQFALLGYLLLGLLAMLLAVETFMELPQVCAMVKFFGASIPVTTEDQDGIVSQDELALNNLPPATPASEQALACRQ
Q801T4_XENLA       LRKLYKVSVAFYLFVGLMAMLLIIQTFHKAADVHGLTDIFYLPRLQDQDDQEPILEPTDYTKDLEPKRPLTTESQTDYSS
Q8HZT2_BOVIN       YPLWYQNTVSLWILFGMAWLALIIKLILSLLEAPRESYSCYPQSSKGNFKPRSWSQGLDEEAGPHSPQPSCSPEGQHPEP
KCNKH_HUMAN        YPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGII
Q9VFS9_DROME       NrpEYVMFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRDEAQAMQALQVAVKLEGDVITSNGSILSGYEGHDGQSLN
Q6X6Z3_HUMAN       QGCGAKAAPGRRPRRGSTAARGVQVTPQDFHISKKGLGS.........................................

                                                                                                                                                                                                        

                                                                                                                                                                                                        
CONSENSUS          IKRKLSAELGDDSRQH                                                                                                                                                                     
KCNK2_MOUSE        VKRKLSAELAGNHNQE................................................................  !  
Q6P6P9_MOUSE       VKRKLSAELAGNHNQE................................................................
Q8HY88_BOVIN       IKRKLSAELAGNHNQE................................................................
Q5DP48_HUMAN       IKRKLSAELAGNHNQE................................................................
Q9NRT2_HUMAN       IKRKLSAELAGNHNQE................................................................
Q920B6_RAT         VKRKLSAELAGNHNQE................................................................
Q5DNW5_RAT         VKRKLSAELAGNHNQE................................................................
KCNK2_HUMAN        IKRKLSAELAGNHNQE................................................................
Q6Q834_RABIT       IRSMERRRLGLDQRAH................................................................
KCNKA_HUMAN        IRSMERRRLGLDQRAH................................................................
Q6B014_HUMAN       IRSMERRRLGLDQRAH................................................................
KCNKA_RAT          IRSMERRRLGLDQRAH................................................................
Q8BUW1_MOUSE       IRSMERRRLGLDQRAH................................................................
Q9Z2T2_RAT         FVASQSPPYEDGSANH................................................................
KCNK1_HUMAN        FVATQSSACVDGPANH................................................................
Q99L99_MOUSE       FVASQSPPYEDGSADH................................................................
Q5RD07_PONPY       FVATQSSACMDGPANH................................................................
KCNK1_MOUSE        FVASQSPPYEDGSADH................................................................
Q8R454_CAVPO       FVAAQVSAYAEDSASH................................................................
Q5UE96_RABIT       FVATPSSACADGPANH................................................................
Q8AVI5_XENLA       SGPDGPLNDDQ.....................................................................
Q5HZV4_XENTR       SVPDGPLNSD......................................................................
KCNK3_RAT          GMGVGVGVGGSGFRNV................................................................
KCNK3_MOUSE        GVGVGVGGSGFRNVYA................................................................
KCNK9_HUMAN        CYRSQDYGGRSVAPQN................................................................
KCNK3_HUMAN        AEVLHFQSMCSCLWYK................................................................
Q63ZI0_XENLA       CYRSHEYTSRMVSHQN................................................................
KCNK4_MOUSE        SLPAPPAVVEPAGRPG................................................................
KCNK9_CAVPO        CYRSQPQNFGATLAPQ................................................................
Q924I4_RAT         SLPAPPAVAEPAHRPG................................................................
KCNKC_HUMAN        DAEGRRLSGELISMRD................................................................
Q76M80_MOUSE       DAEGRRLSGELISMRD................................................................
KCNKC_RAT          DAEGRRLSGELISMRD................................................................
KCNK4_HUMAN        PPCPAQPLGRPRSPSP................................................................
Q923V6_RAT         PGANWGDDDDDDDDAV................................................................
Q5TZ59_BRARE       VYAEVLHFQSMCSCLW................................................................
KCNKD_RAT          GRRLSGEMISMKDTNK................................................................
KCNKD_MOUSE        GRRLSGEMISMKDTNK................................................................
Q9JLD4_RAT         PGANWGDDDDDDDDAV................................................................
KCNKD_HUMAN        GRRLSGEMISMKDLLA................................................................
KCNKF_HUMAN        LERCARDNLGFSPPSS................................................................
Q9ESM5_RAT         GMGVGVGVGGSGFRNV................................................................
KCNKF_RAT          LSPEAVHDCHSSPDRL................................................................
Q5UE95_RABIT       TYNDLIKQIGKKAMKT................................................................
Q9JK62_MOUSE       TYNDLIKQIGKKAMKT................................................................
KCNK5_HUMAN        TYNDLIKQIGKKAMKT................................................................
Q9JJ14_MOUSE       SEHQNRPQPADPSQAT................................................................
Q60VG3_CAEBR       DEKLRHRHRKNNIHTH................................................................
KCNKG_HUMAN        GS..............................................................................
Q9ERU5_RAT         SIPR............................................................................
SUP9_CAEEL         DEKLRHRHRKHTEPHG................................................................
KCNK6_HUMAN        SIPR............................................................................
Q5VSE6_BRARE       RRMSGEMISMKDFLAA................................................................
Q8I6M6_APLCA       TKAPTVTVTDADGDSD................................................................
Q5HZL7_XENLA       TYNDLIKQIGKNGLKD................................................................
Q8R453_CAVPO       SIPR............................................................................
KCNK7_HUMAN        ................................................................................
Q6X6Z4_HUMAN       SKWAPMWLGSSAQV..................................................................
KCNK8_MOUSE        ................................................................................
Q6X6Z5_HUMAN       ................................................................................
Q8QZZ6_CAVPO       VSDDSV..........................................................................
Q801T4_XENLA       INR.............................................................................
Q8HZT2_BOVIN       STQVSCCGKDS.....................................................................
KCNKH_HUMAN        QHLEPSAHAAGCGKDS................................................................
Q9VFS9_DROME       GSNTSSMCSCHCICLN................................................................
Q6X6Z3_HUMAN       ................................................................................


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