2005, KChannelDB.
This multiple sequence alignment displays point mutations extracted from the literature.
The top layer shows the consensus sequence and the putative location of structural and functional domains. Residues with available mutation data are hyperlinked to pages that display information on the point mutants. Those positions are marked by a '!' on the right of the alignment.The 'name' of the mutant is displayed in the bottom bar of your browser when you pass the mouse over a hyperlinked position.
150 160
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CONSENSUS MTLSNSTQVLPFLFRLWQETHHDGGNRSTLARRSALSADGDLEYLYILMVMGFFGFFTLGIMLSYIRSKKLEHSSDPYHV
KCNE1_RAT MALSNSTTVLPFLASLWQETDEPGGNMsdLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV !
Q545H6_MOUSE MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV
KCNE1_MOUSE MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV !
KCNE1_PIG MALSNSTTVLPFLASLWQETDEPGGNMsdLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV
Q5R8Q2_PONPY MILSNTTAVTPFLTKLWQETVQQGGNVSGLARRSPRSDDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNV
KCNE1_HUMAN MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNV !
KCNE1_FELCA MILPNTTATTPFLNALWQGTAHQGGNTSGLARRSPGGDDSQLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV
KCNE1_CAVPO MILPNSTAVMPFLTTVWQGTVQPSSNASGLARRSPLRDDGKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNV
KCNE1_RABIT MIPPNATAVMPFLTTLGEETAhqGSSATSLARRGPLGDDGQMEALYILMVLGFFGFFTLGIMLSYIRSQKLEHSHDPFNV
KCNE2_RAT TTLANLTQTLEDAFKKVFITYMDSWRRNTTAEQQALQARVDAeiLYLMVMIGMFAFIVVAILVSTVKSKRREHSQDPYHQ
KCNE2_CAVPO TTLANLTQTLEDAFKKVFITYMDSWRRNTTAEQQALQARVDAeiLYLMVMIGMFAFIVVAILVSTVKSKRREHSQDPYHQ
Q5FVT9_RAT TTLANLTQTLEDAFKKVFITYMDSWRRNTTAEQQALQARVDAeiLYLMVMIGMFAFIVVAILVSTVKSKRREHSQDPYHQ
KCNE2_MOUSE ATLANLTQTLEDAFKKIFITYMDSWRRNTTAEEQALQARVDAeiLYLMVMIGMFSFIVVAILVSTVKSKRREHSQHPYHQ
Q52LJ5_HUMAN STLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAeiLYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQ
KCNE2_HUMAN STLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAeiLYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQ
KCE1L_HUMAN MNCSESQRLRTLLSRLLLELHHRGNASGLGAGpeVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQ
Q5JWV7_HUMAN MNCSESQRLRTLLSRLLLELHHRGNASGLGAGpeVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQ
Q71FD8_RAT MEPLNSTHPSAAASSSPLESHV...........SSNSGGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREksSLLLLY
KCNE4_MOUSE MEPLNSTYPSAAASSSPLESHVPS...........NSSGNGNEYFYILVVMSFYGVFLIGIMLGYMKSKRREksSLLLLY
KCNE4_HUMAN MEPLNSTHPGTAASSSPLESRAAGG...........GSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREksSLLLLY
KCE1L_MOUSE MNCSESQRLQTLLNRLLLELHHrgVVPDPFVGREATSAKGNDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPPL
Q8C1K1_MOUSE MYCSESQRLQTLLNRLLLELHHrgVVPDPFVGREATSAKGNDAYLYILLIMIFYACLAGGSSWPTPasSSRPRMSHPWPV
KCNE3_MOUSE LKALNTTLHSHLLCRPGPG...PGPDNQTEDRRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHV
KCNE3_RAT LKALNTTLHSHLLCRPGPGpsGTGPDNQTEDHRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHV
KCNE3_HUMAN LKALNATLHSNLLCRPGPGL...GPDNQTEERRASLPGRDDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHV !
Q8MIS1_PIG LKALNATLHSNLLCR.......PGPDHLTEERRAGLPGRDDNSYMYILFVMFLFAATVGSLILGYTRSRKVDKRSDPYHV
CONSENSUS YIEEDAWQEKGKALFQARVLESSRACYVEENQAAGEQPATHLPELKPLS
KCNE1_RAT YIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS...............................
Q545H6_MOUSE YIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS...............................
KCNE1_MOUSE YIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS...............................
KCNE1_PIG YIESDAWQEKGKALFQARVLESFRACYAIENQAAVEQPATHLPELKPLS...............................
Q5R8Q2_PONPY YIESDAWQEKDKAYVQARVLKSYRACYVVENHLAVEQPNTHLPGTKPSP...............................
KCNE1_HUMAN YIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP............................... !
KCNE1_FELCA YIESDTWQEKDKAYLQARVLESYKACYVIENQLAVERPNAHLPEIKPLS...............................
KCNE1_CAVPO YIESDTWQEKDKAFFQARVLENCRSCCVIENQLTVEQPNTYLPEL...................................
KCNE1_RABIT YIEANDWQEKDRAYFQARVLESCRGCYVLENQLAVEHPDTHLPELKPSL...............................
KCNE2_RAT YIVEDWQQ...KYRSQILHLEDSKATIHENLGATGFTVSP........................................
KCNE2_CAVPO YIVEDWQQ...KYRSQILHLEDSKATIHENLGATGFTVSP........................................
Q5FVT9_RAT YIVEDWQQ...KYRSQILHLEDSKATIHENLGATGFTVSP........................................
KCNE2_MOUSE YIVED.WQEKYKS..QILHLEDSKATIHENMGATGFTVSP........................................
Q52LJ5_HUMAN YIVED.WQEKYKS..QILNLEESKATIHENIGAAGFKMSP........................................
KCNE2_HUMAN YIVED.WQEKYKS..QILNLEESKATIHENIGAAGFKMSP........................................
KCE1L_HUMAN ACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV..................................
Q5JWV7_HUMAN ACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV..................................
Q71FD8_RAT KDEERLWGEAMKPLPMMSGLRSGQVPMMLNMLQESVAPALSCTLCSMEG...............................
KCNE4_MOUSE KDEERLWGEAMKPLPMMSGLRSGQVPMMLNMLQESVAPALSCTLCSMEG...............................
KCNE4_HUMAN KDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEG............................... !
KCE1L_MOUSE ACV..AEQEWVPAAIASADPENGQGLLAEGGHQLAAGALPALAQGAERV...............................
Q8C1K1_MOUSE LLSRNGSPLPSHLPTRRMARACWLRAATSSQQGRCLRWLRALRGSRSAV...............................
KCNE3_MOUSE YIKNRVSMI.......................................................................
KCNE3_RAT YIKNRVSMI.......................................................................
KCNE3_HUMAN YIKNRVSMI.......................................................................
Q8MIS1_PIG YIKNRVSMI.......................................................................