KChannelDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in KCNE1_HUMAN at position 74 were found are listed after the table.

Point mutations at position S74 in KCNE1_HUMAN

ProteinKCNE1_HUMAN (P15382)    Gene: KCNE    (other point mutations)Swiss-Prot
Cross-reference table
Family page
PositionS74
General numbering (KChannelDB) -
DomainC-term
Family alignments IsK related channels (minK,MiRP,AMMECR2)
Potassium channels 1 TM
Other point mutations at the same position Position 74 in IsK related channels (minK,MiRP,AMMECR2) family
Position 74 in Potassium channels 1 TM family
Reference #1Tapper AR, George AL Jr
J Gen Physiol 2000 Sep;116(3):379-90.		Medline
Text sourceHTML full text
Point mutationS74L (Not yet checked)
Reference #2Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang ML, Labeit D, Labeit S, Inagaki N, Gregorio CC
J Mol Biol 2001 Nov 2;313(4):775-84.		Medline
Text sourcePDF full text
Point mutationS74L (Not yet checked)
Reference #3Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC
Circulation 2004 Apr 20;109(15):1834-41. Epub 2004 Mar 29.		Medline
Text sourceHTML full text
Point mutationS74L (Not yet checked)

Relevant sentences

Reference #1 (Tapper AR et al.): S74L
  • Three of the mutations , S74L , D76N , and W87R are localized to the MinK COOH-terminal region that we have found to be critical for KvLQT1 gating modulation

Reference #2 (Furukawa T et al.): S74L
  • In this regard , we are currently testing whether mutant forms of minK that are associated with LQTS (e.g. S74L and D76N) have the propensity to interact with T-cap

Reference #3 (Westenskow P et al.): S74L
  • In K2000 , S74L KCNE1 was previously characterized5 and found to cause a 20-mV rightward shift in the voltage dependence of IKs activation and an accelerated rate of deactivation

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F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005