KChannelDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in IRK6_MOUSE at position 94 were found are listed after the table.

Point mutations at position N94 in IRK6_MOUSE

ProteinIRK6_MOUSE (P48542)    Gene: Kcnj6,Girk2, Kcnj7,     (other point mutations)Swiss-Prot
Cross-reference table
Family page
Protein isoforms4
PositionN94
General numbering (KChannelDB) -
DomainN-term
Family alignments Inward rectifiers (Kir)
Potassium channels 2 TMs
Other point mutations at the same position Position 63 in Inward rectifiers (Kir) family
Position 63 in Potassium channels 2 TMs family
Reference #1Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4441-6. Epub 2004 Mar 22.		Medline
Text sourcePDF full text
Point mutationN94D (Not yet checked)
Point mutationN94F (Not yet checked)
Point mutationN94H (Not yet checked)
Point mutationN94M (Not yet checked)

Relevant sentences

Reference #1 (Bichet D et al.): N94D
  • Allele-specific suppression of S177 and E152 mutations but not the weaver mutation by N94 mutations N94Y N94F N94H N94M N94D S177D S177G S177F S177P S177Y S177N S177H E152T E152V E152A E152H E152G weaver Eight substitutions at S177 in M2 (D , G , F , W , P , Y , N , and H) , five substitutions at E152 in the pore helix (T , V , A , H , and G) , and the G156S identified in the pore loop of the gene encoding for the GIRK2 channel of the weaver mouse were found to confer Na permeability to GIRK2 channels (Fig. 10 and Table 3)

Reference #1 (Bichet D et al.): N94F
  • Allele-specific suppression of S177 and E152 mutations but not the weaver mutation by N94 mutations N94Y N94F N94H N94M N94D S177D S177G S177F S177P S177Y S177N S177H E152T E152V E152A E152H E152G weaver Eight substitutions at S177 in M2 (D , G , F , W , P , Y , N , and H) , five substitutions at E152 in the pore helix (T , V , A , H , and G) , and the G156S identified in the pore loop of the gene encoding for the GIRK2 channel of the weaver mouse were found to confer Na permeability to GIRK2 channels (Fig. 10 and Table 3)

Reference #1 (Bichet D et al.): N94H
  • Allele-specific suppression of S177 and E152 mutations but not the weaver mutation by N94 mutations N94Y N94F N94H N94M N94D S177D S177G S177F S177P S177Y S177N S177H E152T E152V E152A E152H E152G weaver Eight substitutions at S177 in M2 (D , G , F , W , P , Y , N , and H) , five substitutions at E152 in the pore helix (T , V , A , H , and G) , and the G156S identified in the pore loop of the gene encoding for the GIRK2 channel of the weaver mouse were found to confer Na permeability to GIRK2 channels (Fig. 10 and Table 3)

Reference #1 (Bichet D et al.): N94M
  • Allele-specific suppression of S177 and E152 mutations but not the weaver mutation by N94 mutations N94Y N94F N94H N94M N94D S177D S177G S177F S177P S177Y S177N S177H E152T E152V E152A E152H E152G weaver Eight substitutions at S177 in M2 (D , G , F , W , P , Y , N , and H) , five substitutions at E152 in the pore helix (T , V , A , H , and G) , and the G156S identified in the pore loop of the gene encoding for the GIRK2 channel of the weaver mouse were found to confer Na permeability to GIRK2 channels (Fig. 10 and Table 3)

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F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005