KChannelDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in IRK2_HUMAN at position 219 were found are listed after the table.

Point mutations at position K219 in IRK2_HUMAN

ProteinIRK2_HUMAN (P63252)    Gene: KCNJ2,HIRK    (other point mutations)Swiss-Prot
Cross-reference table
Family page
PositionK219
General numbering (KChannelDB) -
DomainC-term
Family alignments Inward rectifiers (Kir)
Potassium channels 2 TMs
Other point mutations at the same position Position 201 in Inward rectifiers (Kir) family
Position 201 in Potassium channels 2 TMs family
Reference #1Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE
Neuron 2002 Jun 13;34(6):933-44.		Medline
Text sourceHTML full text
Point mutationK219C (Not yet checked)
Point mutationK219Q (Not yet checked)

Relevant sentences

Reference #1 (Lopes CM et al.): K219C
  • Furthermore , a very dramatic increase in the current level was seen when MTSEA reacted with H53C , R67C , K187C , K188C , R218C , and K219C (e.g. , Figures 3A and 5A)

Reference #1 (Lopes CM et al.): K219Q
  • We found that the mutant channels H53Q , K182Q , K185Q , R218Q , K219Q , R228Q , and R312Q have significantly faster PIP2Ab inhibition than the wild-type , suggesting that the interaction with PIP2 is weakened by each mutation

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F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005