KChannelDB: Point mutations extracted from the literature - IRK5_HUMAN

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Mutation	Location	General numbering	Reference
K23A	N-term		Castle NA et al., Mol Pharmacol 2003	Medline
Y32A	N-term		Castle NA et al., Mol Pharmacol 2003	Medline
C60A	N-term		Zeidner G et al., J Biol Chem 2001	Medline
H64F	N-term		He C et al., J Biol Chem 2002	Medline
Y71Q	N-term		He C et al., J Biol Chem 2002	Medline
L81D	N-term		Dibb KM et al., J Biol Chem 2003	Medline
L84I	N-term		He C et al., J Biol Chem 2002	Medline
S143T	Loop 1-2		Rogalski SL et al., J Biol Chem 2001	Medline
S143T	Loop 1-2		Zeidner G et al., J Biol Chem 2001	Medline
E145Q	Loop 1-2		Dibb KM et al., J Biol Chem 2003	Medline
E145R	Loop 1-2		Dibb KM et al., J Biol Chem 2003	Medline
R155D	Loop 1-2		Dibb KM et al., J Biol Chem 2003	Medline
R155E	Loop 1-2		Dibb KM et al., J Biol Chem 2003	Medline
C185A	TRANSMEM II	264	Sadja R et al., Neuron 2001	Medline
C185R	TRANSMEM II	264	Sadja R et al., Neuron 2001	Medline
S209P	C-term		Casamassima M et al., J Biol Chem 2003	Medline
C216A	C-term		Zeidner G et al., J Biol Chem 2001	Medline
R225I	C-term		Zhang L et al., J Biol Chem 2004	Medline
I229L	C-term		He C et al., J Biol Chem 2002	Medline
I229L	C-term		Zhang L et al., J Biol Chem 2004	Medline
L268I	C-term		He C et al., J Biol Chem 2002	Medline
C316T	C-term		Zeidner G et al., J Biol Chem 2001	Medline
A318C	C-term		He C et al., J Biol Chem 2002	Medline
L339E	C-term		He C et al., J Biol Chem 2002	Medline
C362A	C-term		Zeidner G et al., J Biol Chem 2001	Medline
C363S	C-term		Zeidner G et al., J Biol Chem 2001	Medline
C389A	C-term		Zeidner G et al., J Biol Chem 2001	Medline

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005