KChannelDB: Point mutations extracted from the literature - IRK3_RAT

2005, KChannelDB.

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Protein	IRK3_RAT (Kcnj3,Girk1, Kg)	Swiss-Prot Cross-reference table Family page
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs

Mutation Location General numbering Reference
Y12F N-term Rogalski SL et al., J Biol Chem 2000 Medline

Y67F N-term Rogalski SL et al., J Biol Chem 2000 Medline

H116Q Loop 1-2 Mao J et al., J Biol Chem 2002 Medline

F137S Loop 1-2 Ramu Y et al., Biochemistry 2004 Medline

F137S Loop 1-2 Mao J et al., J Biol Chem 2002 Medline

F137S Loop 1-2 Milovic S et al., J Biol Chem 2004 Medline

F137S Loop 1-2 Mao J et al., Proc Natl Acad Sci U S A 2004 Medline

C179S TRANSMEM II 264 Guo Y et al., J Biol Chem 2002 Medline

S185A C-term Mao J et al., Proc Natl Acad Sci U S A 2004 Medline

E304C C-term Guo Y et al., J Biol Chem 2002 Medline

C310V C-term Guo Y et al., J Biol Chem 2002 Medline

Mutation	Location	General numbering	Reference
Y12F	N-term		Rogalski SL et al., J Biol Chem 2000	Medline
Y67F	N-term		Rogalski SL et al., J Biol Chem 2000	Medline
H116Q	Loop 1-2		Mao J et al., J Biol Chem 2002	Medline
F137S	Loop 1-2		Ramu Y et al., Biochemistry 2004	Medline
F137S	Loop 1-2		Mao J et al., J Biol Chem 2002	Medline
F137S	Loop 1-2		Milovic S et al., J Biol Chem 2004	Medline
F137S	Loop 1-2		Mao J et al., Proc Natl Acad Sci U S A 2004	Medline
C179S	TRANSMEM II	264	Guo Y et al., J Biol Chem 2002	Medline
S185A	C-term		Mao J et al., Proc Natl Acad Sci U S A 2004	Medline
E304C	C-term		Guo Y et al., J Biol Chem 2002	Medline
C310V	C-term		Guo Y et al., J Biol Chem 2002	Medline

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005