KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation D27R was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation D27R in KCMB2_RAT

Point mutation:	D27R
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	KCMB2_RAT (Kcnmb)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCMB2_RAT
Family alignments	Potassium channel beta subunits K(VCa)beta
Other point mutations / same position
Reference:	Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. Xia XM, Ding JP, Lingle CJ J Gen Physiol 2003 Feb;121(2):125-48.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

D27R

Although the wide entryway described for the open state of one bacterial T A B L E V Charge Alterations in a Background of a FI Deletion Construct on 100 mV ln( on(mt) / on( FI)) off 140 mV ln( off(mt) / off( FI)) ln[K* mut / K* 2] fss ln[Kmt / K 2] n ms [kT] ms [kT] [kT] [kT] 2 23.7 2.9 0.88 21.9 4.8 2.25 1.37 0.005 3.93 10 FI 9.8 1.2 -- 2.3 0.3 -- -- 0.204 -- 8 FI-R8 , R14 23.0 2.7 0.853 2.3 0.4 0 0.85 0.47 1.24 5 FI- R8 , R14 , K18 , R19 9.4 0.7 0.0417 0.95 0.07 0.884 0.84 0.53 1.48 6 FI-R8 , R14 , K18 , R19 , K24 , R26 , D16N , E17Q 5.8 0.7 0.525 0.8 0.2 1.056 0.53 0.48 1.28 4 FI-R14 , K18 , R19 , K24 , R26 , K33 , R34 , K35 , K41 7.7 0.6 0.241 1.4 0.2 0.496 0.26 0.35 0.74 4 FI-D16R , E17K 21.8 2.8 0.800 2.2 0.8 0.044 0.84 0.43 1.08 6 FI-D27R , D29R , D32R 13.3 2.9 ( 140 mV) 0.305 0.9 0.1 0.938 1.24 0.72 2.31 6 FI-D16R , E17K D27R , D29R , D32R 132 21 2.600 1.4 0.3 0.496 3.10 0.61 1.81 4 T A B L E V I Insertions and Replacements in the 2 NH2 Terminus Construct on ln( on( mut) / on( 2)) off ln( off( mut) / off( 2)) ln[K*mt / K* 2] fss ln[Kmt / K 2] n Len ms [kT] ms [kT] [kT] [kT] 2 (1:1) 23.7 2.9 -- 21.9 4.8 -- -- 0.005 -- 10 42 INS@9 200 23 2.133 25.0 7.9 0.132 2.00 0.045 2.24 5 56 INS@16 177 18 2.011 35.3 8.1 0.477 1.53 0.1 3.10 5 56 INS@27 32.5 5.3 0.317 25.7 6.7 0.160 0.16 0.020 1.40 7 56 INS@36 55.3 2.6 0.847 17.0 2.0 0.253 1.10 0.005 0.00 --> 56 INS@46 55.3 7.3 0.847 12.8 3.3 0.537 1.38 0.09 2.98 4 56 26-45 / 15Q 14.2 1.8 0.512 15.8 3.1 0.326 0.19 0.003 0.51 4 37 For each Ins@# construct , 14 residues (QQQQQQSGQQQQQQ) were inserted at the indicated position

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005