KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation Y13N was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation Y13N in KCMB2_RAT

Point mutation:	Y13N
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	KCMB2_RAT (Kcnmb)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 13 in KCMB2_RAT
Other point mutations / same protein	List of mutations in KCMB2_RAT
Family alignments	Potassium channel beta subunits K(VCa)beta
Other point mutations / same position
Reference:	Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. Xia XM, Ding JP, Lingle CJ J Gen Physiol 2003 Feb;121(2):125-48.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

Y13N

Furthermore , the fact that two nonoverlapping segments of the NH2 terminus , 69 and 1440 , both abolish inactivation would seem at variance with T A B L E V I I Miscellaneous Mutations in the First 31 Amino Acids of the 2 NH2 Terminus Construct on 100 mV ln( on( mut) / on( 2)) off 140 mV ln( off( mut) / off( 2)) ln[K*mt / K* 2] n ms [kT] ms [kT] [kT] 2 (1:1) 23.7 2.9 -- 21.9 4.8 -- 0 10 T5N 22.3 2.8 0.0609 11.4 1.2 0.652 0.59 7 S6N 32.0 5.5 0.300 8.6 3.7 0.935 1.24 4 G7P 30.7 1.1 0.259 43.7 4.2 0.691 0.43 4 T9N 38.7 3.6 0.490 6.5 1.0 1.215 1.71 7 T5NS6NT9N 36.0 5.5 0.418 29.3 2.3 0.291 0.13 4 S10N 25.5 0.7 0.0732 23.5 6.2 0.0705 0.0027 5 S11N 25.0 2.4 0.0534 16.6 5.1 0.277 0.33 4 S12N 28 2.0 0.167 22.2 3.2 0.0136 0.15 4 Y13N 22.5 2.6 0.0520 34.4 7.4 0.452 0.50 6 Y13T 28.5 2.9 0.184 19.2 2.0 0.132 0.32 4 H15L 23.9 3.4 0.008 33.8 5.8 0.434 0.43 3 N20I 25.4 3.0 0.0693 20.1 7.3 0.0858 0.16 3 I21Y 18.2 1.8 0.264 26.3 7.0 0.183 0.45 3 Y22N 20.8 2.9 0.131 40.3 6.4 0.610 0.74 4 Q23L 20.0 3.0 0.170 21.0 2.0 0.0420 0.13 4 I25Y 14.8 1.5 0.471 31.0 6.2 0.348 0.82 3 H28L 32.3 3.1 0.310 10.4 1.6 0.745 1.05 6 L30YL31Y 17.4 2.3 0.309 24.1 9.9 0.0957 0.41 4 The Journal of General Physiology the idea that only entry of the initial residues is important

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005