KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation S321C was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation S321C in KCNH1_BOVIN

Point mutation:	S321C
Domain:	Loop 3-4
General numbering (KChannelDB):	-
Protein:	KCNH1_BOVIN (KCNH1,EA)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Other point mutations / same protein	List of mutations in KCNH1_BOVIN
Family alignments	eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs
Other point mutations / same position
Reference:	Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Schonherr R, Mannuzzu LM, Isacoff EY, Heinemann SH Neuron 2002 Aug 29;35(5):935-49.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

S321C

(B) Activation kinetics of wild-type (wt) and of cysteine mutants with largest negative (I319C) and largest positive (S321C) shifts in G-V
The strongest negative and positive deviations in Vh relative to wt (11.8mV ą 2.0mV) were 35.8mV ą 2.3mV for I319C and S321C and 2.1mV ą 2.9mV for S321C , respectively (n = 812)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005