2005, KChannelDB.
This data was extracted from Medline abstracts and full texts (when available) in an automated manner.
The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation T432S was found are listed after the table.
The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.
| Point mutation: | T432S | |
| Domain: | Loop 5-6 | |
| General numbering (KChannelDB): | - | |
| Protein: | KCNH1_BOVIN (KCNH1,EA) | Swiss-Prot Cross-reference table Family page |
| Protein isoforms | 2 | |
| Other point mutations / same protein | List of mutations in KCNH1_BOVIN | |
| Family alignments |
eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs | |
| Other point mutations / same position |
Position 581 in K+ voltage-gated channels (Kv1-12,Kca2-5) family | |
| Reference: | Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Chen J, Seebohm G, Sanguinetti MC Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12461-6. | Medline |
| Other point mutations / same article | List | |
| Text source | HTML full text | |
| Validation status | Not yet checked |
Relevant sentences:
T432S
cmbi.ru.nl), 17-Aug-2005