KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation S152H was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation S152H in Q8FHW6_ECOL6

Point mutation:	S152H
Domain:	TRANSMEM V
General numbering (KChannelDB):	550
Protein:	Q8FHW6_ECOL6 (kch,c171)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 152 in Q8FHW6_ECOL6
Other point mutations / same protein	List of mutations in Q8FHW6_ECOL6
Family alignments	KCH 6TMs Archaea and Bacteria potassium channels
Other point mutations / same position	Position 146 in KCH 6TMs family Position 146 in Archaea and Bacteria potassium channels family
Reference:	Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor. Malherbe P, Knoflach F, Broger C, Ohresser S, Kratzeisen C, Adam G, Stadler H, Kemp JA, Mutel V Mol Pharmacol 2001 Nov;60(5):944-54.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

S152H

Moreover , the conversion of this serine 152 to a histidine residue (S152H) did not change the affinity of the mutant compared with the wild-type mGlu3 receptor (K D value of 76 ą 4 nM ; Fig. 4 B)
The replacement of Ser-152 of mGlu3 by aspartate converted the mGlu3 affinity for [3H]LY354740 to a value comparable with that of mGlu2 (K D value of 27 nM for mGlu3 S152D) , whereas the mGlu3 mutation S152H did not change the [3H]LY354740 affinity compared with wild-type receptor

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005