KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation L66K was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation L66K in IRK11_HUMAN

Point mutation:	L66K
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	IRK11_HUMAN (KCNJ1)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK11_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 58 in Inward rectifiers (Kir) family Position 58 in Potassium channels 2 TMs family
Reference:	Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel. Inanobe A, Fujita S, Makino Y, Matsushita K, Ishii M, Chachin M, Kurachi Y J Physiol 2001 Aug 15;535(Pt 1):133-43.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

L66K

The mutations of residues S103 and P144 , which are located away from the binding pocket , did not modulate the effects of RGS4 except in the case of one double mutant (RGS4 / L66K / I67K)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005