This data was extracted from Medline abstracts and full texts (when available) in an automated manner.
The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation T469S was found are listed after the table.
The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.
|General numbering (KChannelDB):||244|
|Protein:||KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG)||Swiss-Prot|
|Other point mutations / same protein / same position||Point mutations at position 469 in KCNH2_HUMAN|
|Other point mutations / same protein||List of mutations in KCNH2_HUMAN|
eag related KCNH (Kv10-12)|
K+ voltage-gated channels (Kv1-12,Kca2-5)
Potassium channels 6 TMs
|Other point mutations / same position||
Position 469 in eag related KCNH (Kv10-12) family |
Position 453 in K+ voltage-gated channels (Kv1-12,Kca2-5) family
Position 239 in Potassium channels 6 TMs family
|Reference:||Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.|
Lees-Miller JP, Duan Y, Teng GQ, Duff HJ
Mol Pharmacol 2000 Feb;57(2):367-74.
|Other point mutations / same article||List|
|Text source||HTML full text|
|Validation status||Not yet checked|