KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation Y652A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation Y652A in KCNH2_HUMAN

Point mutation:	Y652A
Domain:	TRANSMEM VI
General numbering (KChannelDB):	654
Protein:	KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG)	Swiss-Prot Cross-reference table Family page
Protein isoforms	4
Other point mutations / same protein / same position	Point mutations at position 652 in KCNH2_HUMAN
Other point mutations / same protein	List of mutations in KCNH2_HUMAN
Family alignments	eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs
Other point mutations / same position	Position 652 in eag related KCNH (Kv10-12) family Position 640 in K+ voltage-gated channels (Kv1-12,Kca2-5) family Position 400 in Potassium channels 6 TMs family
Reference:	Local Anesthetic Interaction with Human Ether-a-go-go-related Gene (HERG) Channels: Role of Aromatic Amino Acids Y652 and F656. Siebrands CC, Schmitt N, Friederich P Anesthesiology 2005 Jul;103(1):102-112.	Medline
Other point mutations / same article	List
Text source	abstract
Validation status	Not yet checked

Relevant sentences:

Y652A

The aim of this study was to determine the effect of the mutations Y652A and F656A in the putative drug binding region of HERG on the inhibition by bupivacaine , ropivacaine , and mepivacaine
The concentration-response data were described by Hill functions (bupivacaine: wild-type IC50 = 22 + / - 2 mum , n = 38 ; Y652A IC50 = 95 + / - 5 mum , n = 31)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005