KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation F656C was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation F656C in KCNH2_HUMAN

Point mutation:	F656C
Domain:	TRANSMEM VI
General numbering (KChannelDB):	658
Protein:	KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG)	Swiss-Prot Cross-reference table Family page
Protein isoforms	4
Other point mutations / same protein / same position	Point mutations at position 656 in KCNH2_HUMAN
Other point mutations / same protein	List of mutations in KCNH2_HUMAN
Family alignments	eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs
Other point mutations / same position	Position 656 in eag related KCNH (Kv10-12) family Position 644 in K+ voltage-gated channels (Kv1-12,Kca2-5) family Position 404 in Potassium channels 6 TMs family
Reference:	Blockade of HERG cardiac K+ current by antifungal drug miconazole. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y Br J Pharmacol 2004 Dec 13;.	Medline
Other point mutations / same article	List
Text source	abstract
Validation status	Not yet checked

Relevant sentences:

F656C

The S6 domain mutation , F656C , abolished the inhibitory action of miconazole on HERG current indicating that miconazole preferentially binds to an aromatic amino-acid residue within the pore-S6 region

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005