KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation E228Q was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation E228Q in KCNK5_HUMAN

Point mutation:	E228Q
Domain:	TRANSMEM IV
General numbering (KChannelDB):	444
Protein:	KCNK5_HUMAN (KCNK5,TASK)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNK5_HUMAN
Family alignments	Two-pore channels (K2p) Potassium channels 4 TMs 2P
Other point mutations / same position
Reference:	Na(+)-induced inward rectification in the two-pore domain K(+) channel, TASK-2. Morton MJ, Chipperfield S, Abohamed A, Sivaprasadarao A, Hunter M Am J Physiol Renal Physiol 2005 Jan;288(1):F162-9. Epub 2004 Aug 24.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

E228Q

Whole cell currents for E228Q and E251Q recorded in the presence of 50 mM Na+ in the pipette showed a weak inward rectification indistinguishable from that of wild-type TASK-2 (data not shown)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005