2005, KChannelDB.
This data was extracted from Medline abstracts and full texts (when available) in an automated manner.
The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation F656S was found are listed after the table.
The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.
| Point mutation: | F656S | |
| Domain: | TRANSMEM VI | |
| General numbering (KChannelDB): | 658 | |
| Protein: | KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG) | Swiss-Prot Cross-reference table Family page |
| Protein isoforms | 4 | |
| Other point mutations / same protein / same position | Point mutations at position 656 in KCNH2_HUMAN | |
| Other point mutations / same protein | List of mutations in KCNH2_HUMAN | |
| Family alignments |
eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs | |
| Other point mutations / same position |
Position 656 in eag related KCNH (Kv10-12) family Position 644 in K+ voltage-gated channels (Kv1-12,Kca2-5) family Position 404 in Potassium channels 6 TMs family | |
| Reference: | Physicochemical features of the HERG channel drug binding site. Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC J Biol Chem 2004 Mar 12;279(11):10120-7. Epub 2003 Dec 29. | Medline |
| Other point mutations / same article | List | |
| Text source | HTML full text | |
| Validation status | Not yet checked |
Relevant sentences:
F656S
cmbi.ru.nl), 17-Aug-2005