KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation C310V was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation C310V in IRK3_RAT

Point mutation:	C310V
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	IRK3_RAT (Kcnj3,Girk1, Kg)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK3_RAT
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 291 in Inward rectifiers (Kir) family Position 291 in Potassium channels 2 TMs family
Reference:	A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating. Guo Y, Waldron GJ, Murrell-Lagnado R J Biol Chem 2002 Dec 13;277(50):48289-94.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

C310V

The double (GIRK1C53V , C179S and GIRK2C65V , C190S) , triple (GIRK1C53V , C179S , C231S and GIRK2C65V , C190S , C221S) , and quadruple mutants (GIRK1C53V , C179S , C231S , C310V and GIRK2C65V , C190S , C221S , C321V) were generated by subcloning mutated segments using standard procedures

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005