KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation Y144G was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation Y144G in KCMB2_RAT

Point mutation:	Y144G
Domain:	Loop 1-2
General numbering (KChannelDB):	-
Protein:	KCMB2_RAT (Kcnmb)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 144 in KCMB2_RAT
Other point mutations / same protein	List of mutations in KCMB2_RAT
Family alignments	Potassium channel beta subunits K(VCa)beta
Other point mutations / same position	Position 104 in Potassium channel beta subunits K(VCa)beta family
Reference:	Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor. Malherbe P, Knoflach F, Broger C, Ohresser S, Kratzeisen C, Adam G, Stadler H, Kemp JA, Mutel V Mol Pharmacol 2001 Nov;60(5):944-54.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

Y144G

The conversion of this tyrosine to a glycine (Y144G) also led to a statistically significant 6-fold reduction in affinity (P < 0.05 , Student's t test)
Saturation isotherms of [3H]LY354740 binding to the wild-type (black-square) and various point-mutated mGlu2 receptors: T168A ((image)) , R183A (open circle ) , Y144A (triangle ) , Y144S (down-triangle) ; Y144G (diamond ) , D146S (×) (A) and the wild-type ((image)) and point-mutated mGlu3 receptors: S152D (black-square) and S152G (open circle ) (B)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005