KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation L159F was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation L159F in AKT6_ARATH

Point mutation:	L159F
Domain:	TRANSMEM III
General numbering (KChannelDB):	347
Protein:	AKT6_ARATH (AKT6,SPIK,At2g2560)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in AKT6_ARATH
Family alignments	AKT-like Inward rectifiers 6TMs Plant potassium channels
Other point mutations / same position
Reference:	Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel. Inanobe A, Fujita S, Makino Y, Matsushita K, Ishii M, Chachin M, Kurachi Y J Physiol 2001 Aug 15;535(Pt 1):133-43.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

L159F

Otherwise the results obtained with mutations of RGS4 were divided into two groups , those with wild-type characteristics , E87A , N88A , S103E and P144A , and those where the effects of RGS4 on the off-rate and the relaxation of ACh currents were abolished , N128A , N128H , L159F , R167A and F168A
The lack of an effect of either E87A or N88A may be due to the fact that , although lower than the wild-type RGS4 , these mutants retain higher GAP activity than RGS4 / N128A , N128H , L159F and R167A (Natochin et al. 1998 ; Srinivasa et al. 1998)
Nevertheless , the result with RGS4 / N88S and those with N128A , N128H , L159F , R167A and F168A all suggest that the molecular mechanism responsible for accelerating the activation phase of the ACh response is different from that or those for deactivation and relaxation

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005