KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation G132I was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation G132I in IRK11_HUMAN

Point mutation:	G132I
Cited point mutation:	G132I,G132ß
Domain:	Loop 1-2
General numbering (KChannelDB):	-
Protein:	IRK11_HUMAN (KCNJ1)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK11_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 126 in Inward rectifiers (Kir) family Position 126 in Potassium channels 2 TMs family
Reference:	Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants. Capener CE, Proks P, Ashcroft FM, Sansom MS Biophys J 2003 Apr;84(4):2345-56.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

G132ß

The remainder is spent in a predominantly (I131ß , G132ß) combination which corresponds to the Ile carbonyls being oriented away from the pore
From the analysis in Fig. 5 we can also see that neither GF0 nor MC0 exhibits this (I131ß , G132ß) combination
The presence of a single water molecule behind the filter is sufficient to allow this additional conformational space to also be explored by the other mutants and the WT model , with the (I131ß , G132ß) combination structure occurring for ~25% of the time in the WT1 si mulation compared with ~50% for VT1 , ~50% for GF1 , and ~25% for MC1

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005