KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation M1P was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation M1P in IRK5_RAT

Point mutation:	M1P
Cited point mutation:	M1P,M1-P
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	IRK5_RAT (Kcnj5,Girk)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK5_RAT
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position
Reference:	Molecular determinants for activation of G-protein-coupled inward rectifier K+ (GIRK) channels by extracellular acidosis. Mao J, Li L, McManus M, Wu J, Cui N, Jiang C J Biol Chem 2002 Nov 29;277(48):46166-71.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

M1-P

Therefore , we examined amino acid sequences from the first membrane-spanning helix (M1) , the P-loop , to the second membrane-spanning sequence (M2) helix and found a histidine in the M1-P linker (Fig. 4 A)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005