KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation R228Q was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation R228Q in IRK2_HUMAN

Point mutation:	R228Q
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	IRK2_HUMAN (KCNJ2,HIRK)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK2_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 210 in Inward rectifiers (Kir) family Position 210 in Potassium channels 2 TMs family
Reference:	Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE Neuron 2002 Jun 13;34(6):933-44.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

R228Q

We found that the mutant channels H53Q , K182Q , K185Q , R218Q , K219Q , R228Q , and R312Q have significantly faster PIP2Ab inhibition than the wild-type , suggesting that the interaction with PIP2 is weakened by each mutation

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005