KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation A69T was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation A69T in KCNE3_HUMAN

Point mutation:	A69T
Domain:	TRANSMEM I
General numbering (KChannelDB):	157
Protein:	KCNE3_HUMAN (KCNE)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNE3_HUMAN
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 55 in IsK related channels (minK,MiRP,AMMECR2) family Position 55 in Potassium channels 1 TM family
Reference:	A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. Melman YF, Krumerman A, McDonald TV J Biol Chem 2002 Jul 12;277(28):25187-94.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

A69T

To test our hypothesis of the critical role of residue Val-72 of KCNE3 , we constructed KCNE3 mutants A69T KCNE3 and L75T KCNE3
a , A69T KCNE3 representing insertion of threonine one turn up from the central residue in KCNE3
(T58V / G55T , n = 9 ; T58V / I61T , n = 10 ; A69T , n = 5 ; and L75T , n = 4.) (image) View larger version (34K): [in this window] [in a new window] Fig. 4

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005