KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation I61T was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation I61T in KCNE3_HUMAN

Point mutation:	I61T
Domain:	TRANSMEM I
General numbering (KChannelDB):	149
Protein:	KCNE3_HUMAN (KCNE)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNE3_HUMAN
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 47 in IsK related channels (minK,MiRP,AMMECR2) family Position 47 in Potassium channels 1 TM family
Reference:	A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. Melman YF, Krumerman A, McDonald TV J Biol Chem 2002 Jul 12;277(28):25187-94.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

I61T

d , I61T / T58V minK representing substitution of threonine one turn down from the central residue in minK
(T58V / G55T , n = 9 ; T58V / I61T , n = 10 ; A69T , n = 5 ; and L75T , n = 4.) (image) View larger version (34K): [in this window] [in a new window] Fig. 4

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005