KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation L59G was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation L59G in KCNE1_HUMAN

Point mutation:	L59G
Domain:	TRANSMEM I
General numbering (KChannelDB):	161
Protein:	KCNE1_HUMAN (KCNE)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNE1_HUMAN
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 59 in IsK related channels (minK,MiRP,AMMECR2) family Position 59 in Potassium channels 1 TM family
Reference:	A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. Melman YF, Krumerman A, McDonald TV J Biol Chem 2002 Jul 12;277(28):25187-94.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

L59G

Recordings are from CHO cells (obtained as in Fig. 1 ) transfected with KvLQT1 cDNA with F57T / T58V minK (scale bar = 2000 pA) (a) ; F57T / L59G minK (scale bar = 3000 pA) (b) ; T58V / L59G minK (scale bar = 12 , 000 pA) (c) ; T58V minK using voltage protocol with either -80 mV holding potential (left trace) or 3-s conditioning pulse to -120 mV (right trace) before each sweep (scale bar = 4500 pA) (d)
(F57T / L59G , n = 4 ; T58V / L59G , n = 10 ; F57T / T58V , n = 7 ; and T58V , n = 10.) We also introduced threonines into T58V minK at positions 55 and 61 , one turn N- or C-terminal to residue 58 , respectively

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005