KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation K190A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation K190A in IRK1_HUMAN

Point mutation:	K190A
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	IRK1_HUMAN (KCNJ1,ROMK)	Swiss-Prot Cross-reference table Family page
Protein isoforms	3
Other point mutations / same protein	List of mutations in IRK1_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 173 in Inward rectifiers (Kir) family Position 173 in Potassium channels 2 TMs family
Reference:	Structural determinants and specificities for ROMK1-phosphoinositide interaction. Zeng WZ, Liou HH, Krishna UM, Falck JR, Huang CL Am J Physiol Renal Physiol 2002 May;282(5):F826-34.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	Not yet checked

Relevant sentences:

K190A

118 12 6.73 0.04 R188Q 0.14 0.01* 0.13 0.01* 14 3* 7.90 0.03* K190A ND ND 79 8 6.91 0.04 K196A 0.87 0.03 NS 86 11 7.01 0.05 K202A ND ND 127 15 6.91 0.04 R203A 0.87 0.02 NS 93 8 6.88 0.04 K206A 0.89 0.02 NS 81 14 6.83 0.05 R212A 0.79 0.02 NS 133 9 6.77 0.04 R217A 0.67 0.02* 0.03 0.003* 32 2* 7.65 0.03* K218A 0.77 0.03* 0.04 0.002* 28 3* 7.59 0.03* Values are means SE

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005