KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V127A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V127A in IRK11_MOUSE

Point mutation:	V127A
Domain:	Loop 1-2
General numbering (KChannelDB):	-
Protein:	IRK11_MOUSE (Kcnj1)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 127 in IRK11_MOUSE
Other point mutations / same protein	List of mutations in IRK11_MOUSE
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 121 in Inward rectifiers (Kir) family Position 121 in Potassium channels 2 TMs family
Reference:	Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel. Proks P, Capener CE, Jones P, Ashcroft FM J Gen Physiol 2001 Oct;118(4):341-53.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

V127A

The following mutations did not produce functional channels: V127K , V127S , V127A , V127D , E126Q , E126D , F133Y , and the double mutants F133Y + M137C , F133Y + G135F , and V127T + W83F
We attempted to explore the effect of mutating V127 to a range of other amino acids including both charged (V127K , V127D) and uncharged (V127S , V127A) residues , but none of these mutations expressed functional channels

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005