KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V161W was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V161W in IRK2_HUMAN

Point mutation:	V161W
Domain:	TRANSMEM II
General numbering (KChannelDB):	247
Protein:	IRK2_HUMAN (KCNJ2,HIRK)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK2_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 143 in Inward rectifiers (Kir) family Position 143 in Potassium channels 2 TMs family
Reference:	Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Yi BA, Minor DL Jr, Lin YF, Jan YN, Jan LY Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11016-23.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

V161W

The mutation and its suppressors were as follows: W96A was suppressed by F159I / A173P or F159V / A173P ; F99A was suppressed by F159I ; Q164S was suppressed by S95E ; and V161W was suppressed by F103Y / I106N

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005