KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation E179Q was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation E179Q in IRK11_MOUSE

Point mutation:	E179Q
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	IRK11_MOUSE (Kcnj1)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 179 in IRK11_MOUSE
Other point mutations / same protein	List of mutations in IRK11_MOUSE
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 173 in Inward rectifiers (Kir) family Position 173 in Potassium channels 2 TMs family
Reference:	Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel. Xu H, Wu J, Cui N, Abdulkadir L, Wang R, Mao J, Giwa LR, Chanchevalap S, Jiang C J Biol Chem 2001 Oct 19;276(42):38690-6.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

E179Q

Interestingly , when we neutralized Glu-179 , the E179Q mutant showed CO2 sensitivity significantly smaller than that of the wt channel (Fig. 5 B) , indicating that the titratability of His-175 is strongly influenced by its microenvironment

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005