KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation D76N was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation D76N in KCNE1_HUMAN

Point mutation:	D76N
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	KCNE1_HUMAN (KCNE)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 76 in KCNE1_HUMAN
Other point mutations / same protein	List of mutations in KCNE1_HUMAN
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 76 in IsK related channels (minK,MiRP,AMMECR2) family Position 76 in Potassium channels 1 TM family
Reference:	MinK subdomains that mediate modulation of and association with KvLQT1. Tapper AR, George AL Jr J Gen Physiol 2000 Sep;116(3):379-90.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

D76N

Three of the mutations , S74L , D76N , and W87R are localized to the MinK COOH-terminal region that we have found to be critical for KvLQT1 gating modulation

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005